Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Xianjuan Qian"'
Autor:
Jun Wang, Zhong Zhao, Emi Lin, Wei Zhao, Xianjuan Qian, Daniel Freire, Amanda E Bilski, Alice Cheng, Prashant Vempati, Lap Ho, Kenjiro Ono, Masahito Yamada, Giulio M Pasinetti
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65232 (2013)
Alzheimer's disease (AD) is rapidly becoming one of the leading causes of disability and mortality in the elderly. As life-expectancy increases, an increasing number of people will rely on modern medicines to treat age-associated disorders. Among the
Externí odkaz:
https://doaj.org/article/08eba08cf451466ba8c7eaca10899b6a
Autor:
James E. Simon, Elsa M. Janle, Yong Pan, Bruce A. Cooper, Vaishali Sharma, Kenjiro Ono, Daniel Raftery, Jun Wang, Alice Cheng, Xianjuan Qian, Lap Ho, Bing Gong, David B. Teplow, G. A. Nagana Gowda, Constantine Pavlides, Mario G. Ferruzzi, Chungfen Zhang, Isabel Arrieta-Cruz, Richard A. Dixon, Jack W. Blount, Giulio Maria Pasinetti, Jessica Lobo
Publikováno v:
Wang, J; Ferruzzi, MG; Ho, L; Blount, J; Janle, EM; Gong, B; et al.(2012). Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment. Journal of Neuroscience, 32(15), 5144-5150. doi: 10.1523/JNEUROSCI.6437-11.2012. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2w38w7sv
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 32, iss 15
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 32, iss 15
While polyphenolic compounds have many health benefits, the potential development of polyphenols for the prevention/treatment of neurological disorders is largely hindered by their complexity as well as by limited knowledge regarding their bioavailab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13950d86a920aa2fd61ff5cfd2d9093a
https://doi.org/10.1523/jneurosci.6437-11.2012
https://doi.org/10.1523/jneurosci.6437-11.2012
Autor:
Giulio Maria Pasinetti, Jun Wang, Xianjuan Qian, Lap Ho, Merina Varghese, Alice Cheng, Amna Chaudhry, Wei Zhao
Publikováno v:
Translational Neuroscience. 2:1-5
Alzheimer’s disease (AD) is an age-related dementia, with the pathological hallmarks of neuritic plaques and neurofibrillary tangles, brain atrophy and loss of synaptic terminals. Dysfunctional mitochondrial bioenergetics is implicated as a contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b10f10215be7b51dfeb69ca74ab849
https://doi.org/10.2478/s13380-011-0011-8
https://doi.org/10.2478/s13380-011-0011-8
Autor:
Ilana Seror, Wei Zhao, Clive Rosendorff, Sadie Bartholomew, Jun Wang, Zhong Zhao, Lap Ho, Xianjuan Qian, Giulio Maria Pasinetti, Linghong Chen, Nelson Humala
Publikováno v:
Journal of Clinical Investigation. 117:3393-3402
Recent epidemiological evidence suggests that some antihypertensive medications may reduce the risk for Alzheimer disease (AD). We screened 55 clinically prescribed antihypertensive medications for AD-modifying activity using primary cortico-hippocam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4549ae30d34b06a8c432eeac6e266d55
https://doi.org/10.1172/jci31547
https://doi.org/10.1172/jci31547
Autor:
Brad Chewpoy, Dalia Barsyte-Lovejoy, Xianjuan Qian, Arij Al Chawaf, Neelam Gautam, David A. Lovejoy, Liqun Wang
Publikováno v:
General and Comparative Endocrinology. 137:205-216
Neuropeptides that evolved early in metazoan evolution may possess much larger networks of paralogous genes than later evolving peptides due to the increased exposure to gene and genomic duplication events. The corticotropin-releasing factor family o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aa06ce5784760fc9481888b6d75c22
https://doi.org/10.1016/j.ygcen.2004.02.007
https://doi.org/10.1016/j.ygcen.2004.02.007
Autor:
Patrick R. Hof, Xianjuan Qian, David B. Teplow, Constantine Pavlides, Ashley Lamparello, Lap Ho, Dara L. Dickstein, Isabel Arrieta-Cruz, Kenjiro Ono, Giulio Maria Pasinetti, Rakesh Subnani, Wei Zhao, Jun Wang, Mario G. Ferruzzi
Publikováno v:
Neurobiology of aging. 32(12)
Oligomeric β-amyloid (Aβ) has recently been linked to synaptic plasticity deficits, which play a major role in progressive cognitive decline in Alzheimer's disease (AD). Here we present evidence that chronic oral administration of carvedilol, a non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bccb1e3b20307b41a9d68774c32de6
https://pubmed.ncbi.nlm.nih.gov/20579773
https://pubmed.ncbi.nlm.nih.gov/20579773
Autor:
Wei Zhao, Lauren G. Friedman, Cathie M. Pfleger, Lindsay Conley, Jun Wang, Xianjuan Qian, Giulio Maria Pasinetti, Roselle Vittorino, Lap Ho
Publikováno v:
Translational Neuroscience. 1
Huntington’s disease (HD) is a progressive neurodegenerative disorder associated with selective neuronal cell death. Abnormal aggregation of huntingtin protein with polyQ expansion has been shown to be causally linked to HD. Grape seed polyphenolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a3a7166f7949c96efb765f322503c0
https://doi.org/10.2478/v10134-010-0022-y
https://doi.org/10.2478/v10134-010-0022-y
Autor:
Giulio Maria Pasinetti, Kenjiro Ono, Isabel Arrieta-Cruz, Jun Wang, Wei Zhao, Lap Ho, David B. Teplow, Xianjuan Qian
Publikováno v:
Alzheimer's & Dementia. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeb2f40489759198690a05c0c9dad93c
https://doi.org/10.1016/j.jalz.2009.04.958
https://doi.org/10.1016/j.jalz.2009.04.958
Autor:
Carmen Diaz-Ruiz, Lap Ho, Nelson Humala, Jun Wang, Xianjuan Qian, Giulio Maria Pasinetti, Sunil Thomas, P. Martínez-Martín, Hanna Ksiezak-Reding
Publikováno v:
Cardiovascular Psychiatry and Neurology
Epidemiological evidence suggests that hypertension may accelerate the onset and progression of Alzheimer's disease (AD). In this study, we explored the role of hypertension in the neurodegenerative changes associated with Aβ and tau aggregation. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7165bf231e4ea494986c739e5f369b2d
https://pubmed.ncbi.nlm.nih.gov/19936102
https://pubmed.ncbi.nlm.nih.gov/19936102
Autor:
Dalia Barsyte-Lovejoy, Susan Rotzinger, Jackson C. Bittencourt, Franco J. Vaccarino, Denise D. Belsham, Xianjuan Qian, Carol F. Elias, Antonietta De Cristofaro, David A. Lovejoy, Nam C. Wang, Arij Al Chawaf, Liqun Wang
Publikováno v:
Brain research. Molecular brain research. 133(2)
We have previously shown that a bioactive neuropeptide-like sequence is present at the carboxy-terminus of the teneurin transmembrane proteins. We have subsequently called this peptide 'teneurin C-terminal associated peptide' (TCAP). The sequence enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803c9cfb6c5ad4cecd08c7fcfad466cd
https://pubmed.ncbi.nlm.nih.gov/15710242
https://pubmed.ncbi.nlm.nih.gov/15710242