Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Xianjiang, Lan"'
Autor:
Gundeep Kaur, Ren Ren, Michal Hammel, John R Horton, Jie Yang, Yu Cao, Chenxi He, Fei Lan, Xianjiang Lan, Gerd A Blobel, Robert M Blumenthal, Xing Zhang, Xiaodong Cheng
Publikováno v:
Nucleic Acids Research. 51:1674-1686
ZNF410 is a highly-conserved transcription factor, remarkable in that it recognizes a 15-base pair DNA element but has just a single responsive target gene in mammalian erythroid cells. ZNF410 includes a tandem array of five zinc-fingers (ZFs), surro
Autor:
Kunhua Qin, Peng Huang, Ruopeng Feng, Cheryl A. Keller, Scott A. Peslak, Eugene Khandros, Megan S. Saari, Xianjiang Lan, Thiyagaraj Mayuranathan, Phillip A. Doerfler, Osheiza Abdulmalik, Belinda Giardine, Stella T. Chou, Junwei Shi, Ross C. Hardison, Mitchell J. Weiss, Gerd A. Blobel
Publikováno v:
Nature Genetics. 54:874-884
Autor:
Kunhua Qin, Xianjiang Lan, Peng Huang, Megan S. Saari, Eugene Khandros, Cheryl A Keller, Belinda M. Giardine, Osheiza Abdulmalik, Junwei Shi, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Blood.
The fetal (HbF)-to-adult (HbA) hemoglobin switch is a paradigm for developmental gene expression control with relevance to sickle cell disease and b-thalassemia. Polycomb repressive complex (PRC) proteins regulate this switch, and an inhibitor of PRC
Autor:
Peng Huang, Scott A. Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Cheryl A. Keller, Belinda Giardine, Henry W. Bell, Xianjiang Lan, Malini Sharma, John R. Horton, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Merlin Crossley, Ross C. Hardison, Xiaodong Cheng, Gerd A. Blobel
Publikováno v:
Nat Genet
The fetal-to-adult switch in hemoglobin production is a model of developmental gene control with relevance to the treatment of hemoglobinopathies. The expression of transcription factor BCL11A, which represses fetal β-type globin (HBG) genes in adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b27f4d476434f6a5f7d6ba96595d359
https://europepmc.org/articles/PMC9940634/
https://europepmc.org/articles/PMC9940634/
Autor:
Kunhua Qin, Peng Huang, Xianjiang Lan, Megan S. Saari, Eugene Khandros, Osheiza Y. Abdulmalik, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Publikováno v:
Blood. 140:5382-5383
Autor:
Ross C. Hardison, Gerd A. Blobel, Zhe Zhang, Junwei Shi, Xianjiang Lan, Eugene Khandros, Peng Huang, Osheiza Abdulmalik, Jeremy D. Grevet, Carly L. Geronimo, Cheryl A. Keller, Belinda Giardine, Scott A. Peslak
Publikováno v:
Blood Adv
Increasing fetal hemoglobin (HbF) provides clinical benefit in patients with sickle cell disease (SCD). We recently identified heme-regulated inhibitor (HRI, EIF2AK1), as a novel HbF regulator. Because HRI is an erythroid-specific protein kinase, it
Autor:
Kunhua, Qin, Peng, Huang, Ruopeng, Feng, Cheryl A, Keller, Scott A, Peslak, Eugene, Khandros, Megan S, Saari, Xianjiang, Lan, Thiyagaraj, Mayuranathan, Phillip A, Doerfler, Osheiza, Abdulmalik, Belinda, Giardine, Stella T, Chou, Junwei, Shi, Ross C, Hardison, Mitchell J, Weiss, Gerd A, Blobel
Publikováno v:
Nature genetics. 54(6)
The mechanisms by which the fetal-type β-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells remain a fundamental question in human biology and have therapeutic relevance to sickle cell disease and β-thalassemia. Here, w
Autor:
Kunhua Qin, Peng Huang, Ruopeng Feng, Cheryl A. Keller, Scott A. Peslak, Eugene Khandros, Megan S. Saari, Xianjiang Lan, Thiyagaraj Mayuranathan, Phillip A. Doerfler, Osheiza Abdulmalik, Belinda Giardine, Stella T. Chou, Junwei Shi, Ross C. Hardison, Mitchell J. Weiss, Gerd A. Blobel
Publikováno v:
Nature Genetics. 54:906-906
Autor:
Malini Sharma, Kunhua Qin, Xianjiang Lan, Gerd A. Blobel, Junwei Shi, Jennifer A. Yano, Belinda Giardine, Scott A. Peslak, Ross C. Hardison, Eugene Khandros, Peng Huang, Osheiza Abdulmalik, Cheryl A. Keller
Publikováno v:
Blood
Reactivation of fetal hemoglobin remains a critical goal in the treatment of patients with sickle cell disease and β-thalassemia. Previously, we discovered that silencing of the fetal γ-globin gene requires the erythroid-specific eIF2α kinase heme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda9ca0351e1b81a50a9a69534e5c30c
https://europepmc.org/articles/PMC7290097/
https://europepmc.org/articles/PMC7290097/
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Autor:
Ross C. Hardison, Saurabh K. Bhardwaj, Carolyne J. Face, Stella T. Chou, Christopher R. Edwards, Stephen A. Liebhaber, Gerd A. Blobel, Xianjiang Lan, Ben A. Garcia, Junwei Shi, Laavanya Sankaranarayanan, David Posocco, Simone Sidoli, Belinda Giardine, Nicole Hamagami, Osheiza Abdulmalik, Jeremy D. Grevet, Cheryl A. Keller, Xinjun Ji
Publikováno v:
Science. 361:285-290
A CRISPR screen for RBC regulators Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin. Current treatments entail modulating the level of fetal hemoglobin