Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Xianhua, Lin"'
Autor:
Chen Zhang, Guanghui Zhang, Kuan Sun, Jingchao Ren, Jiaming Zhou, Xuan Liu, Fenglong Lin, Huijun Yang, Jinhu Cao, Lin Nie, Pingyang Zhang, Lin Zhang, Ziqian Wang, Haibin Guo, Xianhua Lin, Shuyin Duan, Jia Cao, Hefeng Huang
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105369- (2024)
Summary: Background: Microplastics are environmental pollutants detected in various human organs and tissues. These particles originate from multiple sources including the degradation of larger plastic items and the intentional inclusion in consumer
Externí odkaz:
https://doaj.org/article/59aaa06259a04a9b861ba1385e5245d1
Autor:
Tingcai Pan, Ning Wang, Jiaye Zhang, Fan Yang, Yan Chen, Yuanqi Zhuang, Yingying Xu, Ji Fang, Kai You, Xianhua Lin, Yang Li, Shao Li, Kangyan Liang, Yin-xiong Li, Yi Gao
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Background Various methods have been developed to generate hepatic cells from human pluripotent stem cells (hPSCs) that rely on the combined use of multiple expensive growth factors, limiting industrial-scale production and widespread applic
Externí odkaz:
https://doaj.org/article/45c1121c38f644a38b0f386eaf94a1a7
Autor:
Tingcai Pan, Jiawang Tao, Yan Chen, Jiaye Zhang, Anteneh Getachew, Yuanqi Zhuang, Ning Wang, Yingying Xu, Shenglin Tan, Ji Fang, Fan Yang, Xianhua Lin, Kai You, Yi Gao, Yin-xiong Li
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Background Chemically strategies to generate hepatic cells from human pluripotent stem cells (hPSCs) for the potential clinical application have been improved. However, producing high quality and large quantities of hepatic cells remain chal
Externí odkaz:
https://doaj.org/article/eab6c58f0e3544548efa07f3885e9cf4
Autor:
Weiqiang Lu, Weiwei Yu, Jiacheng He, Wenjuan Liu, Junjie Yang, Xianhua Lin, Yuanjin Zhang, Xin Wang, Wenhao Jiang, Jian Luo, Qiansen Zhang, Huaiyu Yang, Shihong Peng, Zhengfang Yi, Shancheng Ren, Jing Chen, Stefan Siwko, Ruth Nussinov, Feixiong Cheng, Hankun Zhang, Mingyao Liu
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-20 (2020)
Abstract Immune checkpoint blockade (ICB) has a limited effect on colorectal cancer, underlining the requirement of co‐targeting the complementary mechanisms. Here, we identified prostaglandin E2 (PGE2) receptor 4 (EP4) as the master regulator of i
Externí odkaz:
https://doaj.org/article/8125259b5cdd424f86cbdecc874e654a
Autor:
Tingcai Pan, Yan Chen, Yuanqi Zhuang, Fan Yang, Yingying Xu, Jiawang Tao, Kai You, Ning Wang, Yuhang Wu, Xianhua Lin, Feima Wu, Yanli Liu, Yingrui Li, Guodong Wang, Yin-xiong Li
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-15 (2019)
Abstract Background The limited proliferative ability of hepatocytes is a major limitation to meet their demand for cell-based therapy, bio-artificial liver device, and drug tests. One strategy is to amplify cells at the hepatoblast (HB) stage. Howev
Externí odkaz:
https://doaj.org/article/4d132246e1404a1ca480f580e4427a3e
Autor:
Yingying Xu, Jiawang Tao, Xiaorui Yu, Yuhang Wu, Yan Chen, Kai You, Jiaye Zhang, Anteneh Getachew, Tingcai Pan, Yuanqi Zhuang, Fang Yuan, Fan Yang, Xianhua Lin, Yin-xiong Li
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
A population genetic study identified that the asialoglycoprotein receptor 1 (ASGR1) mutation carriers had substantially lower non–HDL-cholesterol (non–HDL-c) levels and reduced risks of cardiovascular diseases. However, the mechanism behind this
Externí odkaz:
https://doaj.org/article/78a5e0ce6a1b4540b212f57c2847b435
Autor:
Kai You, Yan Wang, Xiaoxia Chen, Zhen Yang, Yan Chen, Shenglin Tan, Jiawang Tao, Anteneh Getachew, Tingcai Pan, Yingying Xu, Yuanqi Zhuang, Fan Yang, Xianhua Lin, Yinxiong Li
Publikováno v:
Biochemical and Biophysical Research Communications. 639:20-28
Serum amyloid A (SAA) is an acute response protein that mainly produced by hepatocytes, and it can promote endothelial dysfunction via a pro-inflammatory and pro-thrombotic effect in atherosclerosis and renal disease. Overdose of Acetaminophen (APAP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afa5e303e154937888b2c166c882573
https://doi.org/10.1016/j.bbrc.2022.11.079
https://doi.org/10.1016/j.bbrc.2022.11.079
Autor:
Jiacheng He, Xianhua Lin, Fanhui Meng, Yumiao Zhao, Wei Wang, Yao Zhang, Xiaolei Chai, Ying Zhang, Weiwei Yu, Junjie Yang, Guichao Li, Xuekui Du, Hankun Zhang, Mingyao Liu, Weiqiang Lu
Publikováno v:
Molecules, Vol 27, Iss 4, p 1209 (2022)
Metastatic pancreatic cancer remains a major clinical challenge, emphasizing the urgent need for the exploitation of novel therapeutic approaches with superior response. In this study, we demonstrate that the aberrant activation of prostaglandin E2 (
Externí odkaz:
https://doaj.org/article/48d0fc81e6274849bd58f0e51b32193b
Autor:
Feima Wu, Ge Gao, Tingcai Pan, Zhen Yang, Guosheng Xu, Nasir Abbas, Yanli Liu, Yan Chen, Shenglin Tan, Kai You, Xinrong Ke, Yuanqi Zhuang, Xianhua Lin, Fan Yang, Yin-xiong Li
Publikováno v:
Stem Cell Research, Vol 27, Iss , Pp 5-9 (2018)
The human SMO protein encoded by the smoothened (SMO) gene acts as a positive mediator for Hedgehog signaling. This pathway regulates many cellular activities, developmental morphogenesis, and tumorigenesis. Using CRISPR/Cas9 to edit human embryonic
Externí odkaz:
https://doaj.org/article/50c200c4532040c9b60e23ff2304750d
Autor:
Haiyan, Xu, Jingyi, Li, Luyang, Jin, Dan, Zhang, Bin, Chen, Xinmei, Liu, Xianhua, Lin, Yiting, Huang, Zhanghong, Ke, Juan, Liu, Lin, Gao, Jianzhong, Sheng, Hefeng, Huang
Publikováno v:
Science China Life Sciences. 65:1578-1589
Diabetes is a complex metabolic disorder which can adversely affect reproductive function. SGK1 is found to be up-regulated in multiple tissues of diabetic patients. However, the effects of diabetes on endometrial SGK1 expression and endometrial rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc9b5b78a23ea45e9b43b04e0f9b4e4
https://doi.org/10.1007/s11427-021-2035-2
https://doi.org/10.1007/s11427-021-2035-2