Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Xianhong Ou"'
Autor:
Qiang Wen, Rui Zhang, Kejun Ye, Jun Yang, Hangchuan Shi, Zhu Liu, Yangpeng Li, Ting Liu, Shiyu Zhang, Wanpei Chen, Jingjing Wu, Weichao Liu, Xiaoqiu Tan, Ming Lei, Christopher L.-H. Huang, Xianhong Ou
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge r
Externí odkaz:
https://doaj.org/article/7a7224d6282a486ca9a2c8a589c4d075
Autor:
Tianyi Sun, Alexander Grassam-Rowe, Zhaoli Pu, Yangpeng Li, Huiying Ren, Yanru An, Xinyu Guo, Wei Hu, Ying Liu, Yuqing Zheng, Zhu Liu, Kun Kou, Xianhong Ou, Tangting Chen, Xuehui Fan, Yangyang Liu, Shu Tu, Yu He, Yue Ren, Ao Chen, Zhouchun Shang, Zhidao Xia, Lucile Miquerol, Nicola Smart, Henggui Zhang, Xiaoqiu Tan, Weinian Shou, Ming Lei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract The heterogeneity of functional cardiomyocytes arises during heart development, which is essential to the complex and highly coordinated cardiac physiological function. Yet the biological and physiological identities and the origin of the sp
Externí odkaz:
https://doaj.org/article/b5f3efe1e19049ffbf65c43a0b0faf21
Autor:
Huiying Ren, Xiaolin Zhou, Jun Yang, Kun Kou, Tangting Chen, Zhaoli Pu, Kejun Ye, Xuehui Fan, Dan Zhang, Xinjiang Kang, Zhongcai Fan, Ming Lei, Tianyi Sun, Xiaoqiu Tan, Xianhong Ou
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-9 (2023)
Abstract The development of the cardiac conduction system (CCS) is essential for correct heart function. However, critical details on the cell types populating the CCS in the mammalian heart during the development remain to be resolved. Using single-
Externí odkaz:
https://doaj.org/article/d584a83cce90429bb34a534f89367688
Autor:
Jun Yang, Kejun Ye, Rui Zhang, Xinrong Fan, Rui Xiong, Shiyu Zhang, Qiming Liu, Miao Lin, Bin Wang, Xiaoqiu Tan, Qiang Wen, Xianhong Ou
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115762- (2023)
Arrhythmia is one of the most common cardiovascular diseases. The search for new drugs to suppress various types of cardiac arrhythmias has always been the focus of attention. In the past decade, the screening of antiarrhythmic active substances from
Externí odkaz:
https://doaj.org/article/aeca184bd06b427398addc812313384f
Autor:
Chendong Peng, Yuang Jiang, Xianhong Ou, Lei Liao, Chengying Yang, Qiao Zhou, Yan Wei, Lijia Chang, Xinrong Fan
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background The X-linked inhibitor of apoptosis (XIAP) protein is encoded by the XIAP gene and is critical for multiple cell responses and plays a role in preventing cell death. XIAP mutations are associated with several diseases, primarily i
Externí odkaz:
https://doaj.org/article/2516186a8d9049d88164583c55b3bad7
Autor:
Shicheng He, Kun Kou, Christopher O’Shea, Tangting Chen, Razik Mu-u-min, Ruirui Dong, Huiying Ren, Xiaolin Zhou, Zhongcai Fan, Xiaoqiu Tan, Davor Pavlovic, Xianhong Ou, Ming Lei
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-9 (2021)
Measurement(s) transmembrane potential • calcium transient Technology Type(s) high-throughput simultaneous optical imaging Sample Characteristic - Organism Mus musculus Machine-accessible metadata file describing the reported data: https://doi.org/
Externí odkaz:
https://doaj.org/article/a69b743109914280822e461245d3ec43
Autor:
Xinrong Fan, Chao Wang, Na Wang, Xianhong Ou, Hanxiong Liu, Yan Yang, Xitong Dang, Xiaorong Zeng, Lin Cai
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 4, Pp 235-243 (2016)
Acehytisine, a multi-ion channel blocker, can markedly inhibit INa, ICa, IKur, If at various concentrations and effectively terminate and prevent atrial fibrillation (AF) in patients and animal models, but the molecular mechanism underlying its block
Externí odkaz:
https://doaj.org/article/4fb6e00e446741ccb9ab48f6e7b9e2ac
Autor:
Ruirui Dong, Razik Mu-u-min, Alastair J. M. Reith, Christopher O’Shea, Shicheng He, Kaizhong Duan, Kun Kou, Alexander Grassam-Rowe, Xiaoqiu Tan, Davor Pavlovic, Xianhong Ou, Ming Lei
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Among the animal models for studying the molecular basis of atrial and sinoatrial node (SAN) biology and disease, the mouse is a widely used species due to its feasibility for genetic modifications in genes encoding ion channels or calcium handling a
Externí odkaz:
https://doaj.org/article/4eda4a1343e84d108df68cd11554f4b7
Autor:
Xuehui Fan, Tianyi Sun, William Crawford, Xiaoqiu Tan, Xianhong Ou, Derek A. Terrar, Steven N. Ebert, Ming Lei
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics,
Externí odkaz:
https://doaj.org/article/ba72eceea47d4f87bc2679704990f26f
Autor:
Christopher O’Shea, Andrew P. Holmes, James Winter, Joao Correia, Xianhong Ou, Ruirui Dong, Shicheng He, Paulus Kirchhof, Larissa Fabritz, Kashif Rajpoot, Davor Pavlovic
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Optogenetic control of the heart is an emergent technology that offers unparalleled spatio-temporal control of cardiac dynamics via light-sensitive ion pumps and channels (opsins). This fast-evolving technique holds broad scope in both clinical and b
Externí odkaz:
https://doaj.org/article/aa76aedd67af402da86b54aa8afff02e