Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Xiangzi Han"'
Autor:
Jing Hao, Xiangzi Han, Haidong Huang, Xingjiang Yu, Jiankang Fang, Jianjun Zhao, Richard A. Prayson, Shideng Bao, Jennifer S. Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials. Here, we report a mechanism of WNT pathway activation through the Semaphorin 3 C ne
Externí odkaz:
https://doaj.org/article/755b7c691e6f4c8daf2bd64dcdd8c5bd
Autor:
Jing Hao, Xiangzi Han, Haidong Huang, Xingjiang Yu, Jiankang Fang, Jianjun Zhao, Richard A. Prayson, Shideng Bao, Jennifer S. Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a2dd8912850549ceb2df62b7241c2302
PDF file - 593K, S1 (A) HEK293T cells were transfected with Myc-Chk1 WT or D148A mutant for 48 hr, treated with 2 �M MG132 for additional 12 hr, and immunoblotted with indicated antibodies. (B) Alignment of the domain from CM1 to the distal C-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7339ecebcb2a58dfee50d4c8e21c95c
https://doi.org/10.1158/0008-5472.22392807.v1
https://doi.org/10.1158/0008-5472.22392807.v1
Autor:
Jennifer Yu, Jing Hao, Xiangzi Han, Haidong Huang, Xingjiang Yu, Richard Prayson, Shideng Bao
Publikováno v:
WFNOS 2022 Abstract Book.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223b6efcd750b12c7e2758299e7744b2
https://doi.org/10.14791/btrt.2022.10.f-1382
https://doi.org/10.14791/btrt.2022.10.f-1382
Autor:
Jing Hao, Xiangzi Han, Haidong Huang, xingjiang yu, Shideng Bao, Richard Prayson, Jennifer Yu
Publikováno v:
Neuro-Oncology. 23:vi77-vi77
BACKGROUND Wnt signaling is widely dysregulated in cancer. The therapeutic potential of Wnt inhibitors appears promising in preclinical studies. However, they have uniformly failed clinical trials. How cancer cells develop Wnt inhibitor resistance is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b352c54868443779f57c558c8f874c8
https://doi.org/10.1093/neuonc/noab196.299
https://doi.org/10.1093/neuonc/noab196.299
Autor:
Shideng Bao, Gurkan Bebek, Jianjun Zhao, Xiangzi Han, Eckhard Jankowsky, Richard A. Prayson, Jing Hao, Xingjiang Yu, Haidong Huang, Jennifer S. Yu, Ahmad M. Khalil
Publikováno v:
Cell reports
SUMMARY Piwi proteins are a subfamily of Argonaute proteins that maintain germ cells in eukaryotes. However, the role of their human homologs in cancer stem cells, and more broadly in cancer, is poorly understood. Here, we report that Piwi-like famil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449f2ddf4d8b3b0e3d5cf767084e2f2d
https://doi.org/10.1016/j.celrep.2020.108522
https://doi.org/10.1016/j.celrep.2020.108522
Autor:
Shuming Yang, Allison G. Condie, Xiangzi Han, Yan Xu, Yulan Qing, Yan Yan, Stanton L. Gerson, Shashank Gorityala, Youwei Zhang
Publikováno v:
Oncotarget
// Yan Yan 1 , Xiangzi Han 1 , Yulan Qing 2 , Allison G. Condie 3 , Shashank Gorityala 4 , Shuming Yang 2 , Yan Xu 2, 4 , Youwei Zhang 1 , Stanton L. Gerson 2 1 Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA 2 Departm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32568783a8934112a8850ce8391f2021
https://doi.org/10.18632/oncotarget.11151
https://doi.org/10.18632/oncotarget.11151
Autor:
Feng Ren, Xin-Sheng Yao, Krzysztof Palczewski, Jingna Wang, Philip D. Kiser, Xiangzi Han, Paul S.-H. Park, Jinshan Tang, Jinhua Zheng, Megan Gragg, Youwei Zhang
Publikováno v:
Journal of Biological Chemistry. 291:12951-12959
Phosphorylation of Chk1 by ataxia telangiectasia-mutated and Rad3-related (ATR) is critical for checkpoint activation upon DNA damage. However, how phosphorylation activates Chk1 remains unclear. Many studies suggest a conformational change model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f9041490fb09e0d818a56d583c840d
https://doi.org/10.1074/jbc.m115.713248
https://doi.org/10.1074/jbc.m115.713248
Publikováno v:
Cancer Research. 72:3786-3794
Checkpoint kinase 1 (Chk1), a serine/threonine protein kinase, is centrally involved in cell-cycle checkpoints and cellular response to DNA damage. Phosphorylation of Chk1 at 2 Ser/Gln (SQ) sites, Ser-317 and Ser-345, by the upstream kinase ATR is cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dbe48a03798016e28921dfd1bede77
https://doi.org/10.1158/0008-5472.can-12-0523
https://doi.org/10.1158/0008-5472.can-12-0523
Autor:
Jinsil Chung, Franklin Mayca Pozo, Darcie D. Seachrist, Ruth A. Keri, Lei Zhang, Youwei Zhang, James W. Jacobberger, Amanda Phuong Tran, Xiangzi Han, Hannah Gilmore
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(49)
DNA double-strand break (DSB) repair is not only key to genome stability but is also an important anticancer target. Through an shRNA library-based screening, we identified ubiquitin-conjugating enzyme H7 (UbcH7, also known as Ube2L3), a ubiquitin E2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fbf2d01bd99d5a97172529298d6396
https://pubmed.ncbi.nlm.nih.gov/25422456
https://pubmed.ncbi.nlm.nih.gov/25422456