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pro vyhledávání: '"Xiangyi S. Wang"'
Autor:
Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation
Externí odkaz:
https://doaj.org/article/6df400b1fdfd4a3a9df0102e30295f9d
Autor:
Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg
The RING-between-RING (RBR) E3 ubiquitin ligase family in humans comprises 14 members and is defined by a two-step catalytic mechanism in which ubiquitin is first transferred from an E2 to the RBR active site and then to the substrate. To define the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afbba9216eef059c022c842b0d2bc6d6
https://doi.org/10.1101/2022.10.11.511834
https://doi.org/10.1101/2022.10.11.511834
Autor:
Thomas R. Cotton, Simon A. Cobbold, Jonathan P. Bernardini, Lachlan W. Richardson, Xiangyi S. Wang, Bernhard C. Lechtenberg
Publikováno v:
Molecular Cell. 82:598-615.e8
An increasing number of genetic diseases are linked to deregulation of E3 ubiquitin ligases. Loss-of-function mutations in the RING-between-RING (RBR) family E3 ligase RNF216 (TRIAD3) cause Gordon-Holmes syndrome (GHS) and related neurodegenerative d