Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Xiangyi Jiang"'
Autor:
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A. Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X. Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract HIV-1 reverse transcriptase is one of the most attractive targets for the treatment of AIDS. However, the rapid emergence of drug-resistant strains and unsatisfactory drug-like properties seriously limit the clinical application of HIV-1 non
Externí odkaz:
https://doaj.org/article/c38865deec50478fa334e921f6a1050d
Autor:
Shujing Xu, Lin Sun, Waleed A. Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 23, p 8415 (2022)
HIV-1 capsid (CA) performs multiple roles in the viral life cycle and is a promising target for antiviral development. In this work, we describe the design, synthesis, assessment of antiviral activity, and mechanistic investigation of 20 piperazinone
Externí odkaz:
https://doaj.org/article/08d03fb8fcbd442c925e5a2912ff863d
Autor:
Xujie Zhang, Lin Sun, Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 21, p 7640 (2022)
The AIDS pandemic is still of importance. HIV-1 and HIV-2 are the causative agents of this pandemic, and in the absence of a viable vaccine, drugs are continually required to provide quality of life for infected patients. The HIV capsid (CA) protein
Externí odkaz:
https://doaj.org/article/4747e126c91b4eba9aaa4d43818f911e
Autor:
Xiangkai Ji, Xiangyi Jiang, Chisa Kobayashi, Yujie Ren, Lide Hu, Zhen Gao, Dongwei Kang, Ruifang Jia, Xujie Zhang, Shujie Zhao, Koichi Watashi, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 18, p 5987 (2022)
Hepatitis B virus (HBV) capsid protein (Cp) is necessary for viral replication and the maintenance of viral persistence, having become an attractive target of anti-HBV drugs. To improve the water solubility of HBV capsid protein allosteric modulator
Externí odkaz:
https://doaj.org/article/1d9c774993254a6aa2d0692cfebd1d4b
Autor:
Xiangkai Ji, Jing Li, Prem Prakash Sharma, Xiangyi Jiang, Brijesh Rathi, Zhen Gao, Lide Hu, Dongwei Kang, Erik De Clercq, Simon Cocklin, Chuanfeng Liu, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 18, p 5995 (2022)
As a key structural protein, HIV capsid (CA) protein plays multiple roles in the HIV life cycle, and is considered a promising target for anti-HIV treatment. Based on the structural information of CA modulator PF-74 bound to HIV-1 CA hexamer, 18 nove
Externí odkaz:
https://doaj.org/article/97f7765db41045cbadc4b893f8b9bc68
Autor:
Shuo Wang, Yujie Ren, Zhao Wang, Xiangyi Jiang, Shujing Xu, Xujie Zhang, Shujie Zhao, Waleed A Zalloum, Xinyong Liu, Peng Zhan
Publikováno v:
Expert Opinion on Drug Discovery. 17:1329-1340
Boron has attracted extensive interest due to several FDA-approved boron-containing drugs and other pharmacological agents in clinical trials. As a semimetal, it has peculiar biochemical characteristics which could be utilized in designing novel drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41d1a8224c9c12b5c1e1a75af60d9e0
https://doi.org/10.1080/17460441.2023.2153829
https://doi.org/10.1080/17460441.2023.2153829
Autor:
Xiangyi Jiang, Prem Prakash Sharma, Brijesh Rathi, Xiangkai Ji, Lide Hu, Zhen Gao, Dongwei Kang, Zhao Wang, Minghui Xie, Shujing Xu, Xujie Zhang, Erik De Clercq, Simon Cocklin, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Journal of Medical Virology. 94:5975-5986
Human immunodeficiency virus (HIV) capsid (CA) protein is a promising target for developing novel anti-HIV drugs. Starting from highly anticipated CA inhibitors PF-74, we used scaffold hopping strategy to design a series of novel 1,2,4-triazole pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb156db7c886743198b168215f00ca1e
https://doi.org/10.1002/jmv.28064
https://doi.org/10.1002/jmv.28064
Autor:
Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan, Dongwei Kang, Wenbo Wang, Xiangyi Jiang, Waleed A. Zalloum, Zhao Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:13658-13675
Enlightened by the available structural biology information, a novel series of dihydrothiopyrano[4,3-d]pyrimidine derivatives were rationally designed via scaffold hopping and molecular hybridization strategies. Notably, compound 20a yielded exceptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::821f048ccd5acba1e4a783a704f10352
https://doi.org/10.1021/acs.jmedchem.1c01015
https://doi.org/10.1021/acs.jmedchem.1c01015
Autor:
Zhao Wang, Srinivasulu Cherukupalli, Minghui Xie, Wenbo Wang, Xiangyi Jiang, Ruifang Jia, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Peng Zhan, Xinyong Liu
Publikováno v:
Journal of medicinal chemistry. 65(5)
Currently, HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a major component of the highly active anti-retroviral therapy (HAART) regimen. However, the occurrence of drug-resistant strains and adverse reactions after long-term usag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ede8ed65b3ef1e31c768f891faa4dd
https://pubmed.ncbi.nlm.nih.gov/35175760
https://pubmed.ncbi.nlm.nih.gov/35175760
Autor:
Dongwei, Kang, Yanying, Sun, Da, Feng, Shenghua, Gao, Zhao, Wang, Lanlan, Jing, Tao, Zhang, Xiangyi, Jiang, Hao, Lin, Erik, De Clercq, Christophe, Pannecouque, Peng, Zhan, Xinyong, Liu
Publikováno v:
Journal of medicinal chemistry. 65(3)
Here, we report the design, synthesis, structure-activity relationship studies, antiviral activity, enzyme inhibition, and druggability evaluation of dihydrofuro[3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eef881564d629afc21745976d208caf2
https://pubmed.ncbi.nlm.nih.gov/35061384
https://pubmed.ncbi.nlm.nih.gov/35061384