Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Xiangxu Tang"'
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Akademický článek
Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction
Autor: Duomeng Yang, Xiaomeng Dai, Yun Xing, Xiangxu Tang, Guang Yang, Andrew G. Harrison, Jason Cahoon, Hongmei Li, Xiuxiu Lv, Xiaohui Yu, Penghua Wang, Huadong Wang
Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Yang et al report that intrinsic cardiac adrenergic cell-derived norepinephrine promotes myocardial dysfunction in response to LPS. They demonstrate norepinephrine produced by these cells activated β1-adrenergic receptors on cardiomyocytes increasin
Externí odkaz: https://doaj.org/article/64750389eaec41ae848b11d3047e9fb1
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3
The Long-term Effect of Dobutamine on Intrinsic Myocardial Function and Myocardial Injury in Septic Rats with Myocardial Dysfunction
Autor: Xiangxu Tang, Duomeng Yang, Yaqian Xu, Huadong Wang, Qingyang Huang, Yun Xing, Hongmei Li, Daxiang Lu, Yiyang Wang, Xiuxiu Lv, Xiaomeng Dai
Publikováno v: Shock. 56:582-592
Dobutamine (DOB) is recommended as an inotrope for septic patients with low cardiac output, but its long-term impact on sepsis-induced cardiomyopathy remains unclear. This study investigated the long-term effect of DOB on septic myocardial dysfunctio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db1492870794b050350960b8cd4e4d2
https://doi.org/10.1097/shk.0000000000001718
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4
Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice
Autor: Jiashuo Teng, Xiaomeng Dai, Jia Liao, Yiyang Wang, Hongmei Li, Huadong Wang, Xiuxiu Lv, Xiangxu Tang, Yingwei Wang, Xingyu Su, Kaiying Li, Yun Xing, Yaqian Xu, Yihua Chen
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12749, p 12749 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12749
Dexmedetomidine (DEX), a selective α2 adrenergic receptor (AR) agonist, is commonly used as a sedative drug during critical illness. In the present study, we explored a novel accelerative effect of DEX on cardiac fibroblast (CF) differentiation medi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e97e57c7e6d2d83a0475716d8042414
http://europepmc.org/articles/PMC8657501
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5
Alpha-1 Adrenergic Receptor Agonist Phenylephrine Inhibits Sepsis-Induced Cardiomyocyte Apoptosis and Cardiac Dysfunction via Activating ERK1/2 Signal Pathway
Autor: Xiangxu Tang, Hongmei Li, Hua-dong Wang, Duomeng Yang, Da-xiang Lu, Yun Xing
Publikováno v: Shock. 52:122-133
It was demonstrated that α1 adrenergic receptor (α1-AR) activation by phenylephrine (PE) attenuated cardiac dysfunction in lipopolysaccharide (LPS)-challenged mice. However, it is unclear whether PE suppresses sepsis-induced cardiomyocyte apoptosis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2246eb4d205325d820af3d84c36017f
https://doi.org/10.1097/shk.0000000000001205
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6
Intrinsic cardiac adrenergic cells contribute to septic cardiomyopathy
Autor: Xiaohui Yu, Guang Yang, Hongmei Li, Yun Xing, Xiangxu Tang, Andrew G. Harrison, Duomeng Yang, Xiaomeng Dai, Huadong Wang, Xiuxiu Lv, Penghua Wang
Occurring independently of cardiac sympathetic nervous system, the intrinsic cardiac adrenergic (ICA) cells have been identified as an important regulator in both of developing and adult cardiac physiological and pathological processes. However, its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b2fc1b2db24667551a603fe1f6362c4
https://doi.org/10.1101/2021.03.02.433552
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7
Activation of the α2A adrenoceptor in microglia promotes LPS-induced TNF-α production and cognitive impairment in mice
Autor: Duomeng Yang, Hui Xu, Huadong Wang, Li-bing Zhou, Yun Xing, Rui-jie Wang, Yaqian Xu, Hong-Ke Zeng, Xiangxu Tang, Ming Fang, Xiaomeng Dai, Wen-Liang Song
Background: a2A adrenoceptor receptor (a2A-AR) plays an important role in inflammatory response in Kupffer cells in sepsis. Blockage of a2A-AR inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor a (TNF-a) production and protects the targe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::000007bec709cf7cd122bcc6c1aaa9fe
https://doi.org/10.21203/rs.2.23544/v1
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8
α2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation
Autor: Chaofeng Hu, Hongmei Li, Yuan Wang, Duomeng Yang, Huadong Wang, Xiangxu Tang, Xiaohui Yu, Xiuxiu Lv, Daxiang Lu, Renbin Qi, Ben Lv
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α2A-adrenergic receptor (AR) blockade on sep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24b4cc719ad0b5b5c2eb36e212a5c87
http://link.springer.com/article/10.1038/s41598-018-23304-7
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9
Phenylephrine Attenuated Sepsis-Induced Cardiac Inflammation and Mitochondrial Injury Through an Effect on the PI3K/Akt Signaling Pathway
Autor: Xiangxu Tang, Daxiang Lu, Duomeng Yang, Huadong Wang, Xiaomeng Dai, Kaiying Li, Yun Xing, Hongmei Li
Publikováno v: Journal of cardiovascular pharmacology. 73(3)
Objective To investigate whether phenylephrine (PE) inhibits sepsis-induced cardiac dysfunction, cardiac inflammation, and mitochondrial injury through the PI3K/Akt signaling pathway. Methods A rat model of sepsis was established by cecal ligation an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ca119c8863b9dd0d9a55917bf0eecf
https://pubmed.ncbi.nlm.nih.gov/30839512
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10
A new method for neonatal rat ventricular myocyte purification using superparamagnetic iron oxide particles
Autor: Xiangxu Tang, Duomeng Yang, Xiuxiu Lv, Hongmei Li, Yun Xing, Xiaomeng Dai, Kaiying Li, Daxiang Lu, Junmin Xi, Huadong Wang
Publikováno v: International journal of cardiology. 270
Background Neonatal rat ventricular myocytes (NRVMs) have proven to be an ideal research model for cardiac disease. However, the current methods to purify NRVMs have a limitation to obtain high purity. The purpose of this study was to develop a NRVM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78e51a861fd2e6a29bf1ed8c85204b0
https://pubmed.ncbi.nlm.nih.gov/29908831
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