Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Xiangxin Zhao"'
Autor:
Ruifeng Wang, Yixuan Chen, Dongmei Zhao, Sijia Yu, Tianxiao Wu, Xiangxin Zhao, Bowen Yang, Maosheng Cheng, Chenzhou Hao
Publikováno v:
European journal of medicinal chemistry. 188
A series of 2,7-disubstituted-thieno[3,2-d]pyrimidine derivatives were designed, synthesized and evaluated as novel focal adhesion kinase (FAK) inhibitors. The novel 2,7-disubstituted-thieno[3,2-d]pyrimidine scaffold has been designed as a new kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79f4d894477b86ea0daed05d2d5a1ae
https://pubmed.ncbi.nlm.nih.gov/31923858
https://pubmed.ncbi.nlm.nih.gov/31923858
Autor:
Ruifeng Wang, Sijia Yu, Dongmei Zhao, Tianxiao Wu, Maosheng Cheng, Yixuan Chen, Chenzhou Hao, Bowen Yang, Xiangxin Zhao, Jing Guo
Publikováno v:
European journal of medicinal chemistry. 183
A series of 7H-pyrrolo[2,3-d]pyrimidine derivatives possessing a dimethylphosphine oxide moiety were designed, synthesized and evaluated as novel Focal adhesion kinase (FAK) inhibitors. Most compounds potently suppressed the enzymatic activities of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9c8d645c30909149254a4fe9e55b89
https://pubmed.ncbi.nlm.nih.gov/31550660
https://pubmed.ncbi.nlm.nih.gov/31550660
Autor:
Dongmei Zhao, Ruifeng Wang, Xiangxin Zhao, Maosheng Cheng, Hengxian Cui, Chenzhou Hao, Tianxiao Wu, Yixuan Chen, Sijia Yu
Publikováno v:
Bioorganic Chemistry. 102:104092
Focal adhesion kinase (FAK) is an intracellular non-receptor tyrosine kinase responsible for development of various tumor types. Aiming to explore new potent inhibitors, two series of 2,4-disubstituted-7H-pyrrolo[2,3-d]pyrimidine derivatives were des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef4f3f06d1420e54945359bfed03b6b
https://doi.org/10.1016/j.bioorg.2020.104092
https://doi.org/10.1016/j.bioorg.2020.104092