Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Xiangshu Fei"'
Autor:
Qi Huang Zheng, Xiangshu Fei
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 28:939-945
New radiolabeled matrix metalloproteinase inhibitors (MMPIs) [11C]Me‐Halo‐CGS 27023A analogs have been synthesized for evaluation as potential novel positron emission tomography (PET) tumor imaging agents. Their lipophilicity coefficients (log P)
Autor:
Xiangshu Fei, Qi Huang Zheng, Barbara E. Glick-Wilson, Michael L. Sullivan, Ji Quari Wang, Gary D. Hutchins, Bruce H. Mock, Timothy R. DeGrado
Publikováno v:
Synthetic Communications. 34:1897-1907
An improved synthesis of [11C]raclopride is reported. The precursor desmethyl‐raclopride was synthesized from 3,5‐dichloro‐2,6‐dimethoxybenzoic acid and (S)‐(−)‐2‐aminoethyl‐1‐ethylpyrrolidine via a straightforward, four‐step sy
Autor:
Qi Huang Zheng, Xuan Liu, Michael L. Sullivan, Barbara E. Glick-Wilson, Ji Quan Wang, Thomas A. Gardner, Sudhanshu P. Raikwar, Bruce H. Mock, Xiangshu Fei, Chinghai Kao, Gary D. Hutchins
Publikováno v:
Synthetic Communications. 34:917-932
An improved total synthesis of [18F]FHPG starting from 1,3‐dibenzyloxy‐2‐propanol and guanine has been developed. [18F]FHPG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/Kryptofix 2.2.2 followed by a quick
Autor:
Xuan Liu, Barbara E. Glick-Wilson, Bruce H. Mock, Michael L. Sullivan, Xiangshu Fei, Gary D. Hutchins, Ji Quan Wang, Thomas A. Gardner, Sudhanshu P. Raikwar, Qi Huang Zheng, Chinghai Kao
Publikováno v:
Synthetic Communications. 34:689-704
An improved total synthesis of [18F]FHBG starting from triethyl‐1,1,2‐ethanetricarboxylate and 2‐amino‐6‐chloropurine is reported. [18F]FHBG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/Kryptofix 2.2.2
Autor:
George W. Sledge, Gary D. Hutchins, Kathy D. Miller, Xiangshu Fei, Qi Huang Zheng, Ji Quan Wang
Publikováno v:
Nuclear Medicine and Biology. 31:1033-1041
Xeloda (Capecitabine), a prodrug of antitumor agent 5-fluorouracil, is the first and only oral fluoropyrimidine to be approved for use as second-line therapy in metastatic breast cancer, colorectal cancer, and other solid malignancies. Fluorine-18 la
Autor:
William J. Groh, John C. Lopshire, Gary D. Hutchins, Douglas P. Zipes, Michael A. Miller, K. Lee Stone, Qi Huang Zheng, Xiangshu Fei, Ji Quan Wang
Publikováno v:
Nuclear Medicine and Biology. 31:957-964
A series of 11C-labeled analogs of the acetylcholinesterase (AChE) inhibitor pyridostigmine have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart AChE. The appropriate precursors for radiola
Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues
Autor:
K. Lee Stone, Tanya D. Martinez, Qi Huang Zheng, Xiangshu Fei, Kathy D. Miller, George W. Sledge, Gary D. Hutchins, Ji Quan Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1247-1251
Radiolabeled antimitotic agents [11C]T138067 and [18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were p
Autor:
Qi-Huang Zheng, Xiangshu Fei, Xuan Liu, Ji-Quan Wang, K Lee Stone, Tanya D Martinez, Dawn J Gay, Winston L Baity, Kathy D Miller, George W Sledge, Gary D Hutchins
Publikováno v:
Nuclear Medicine and Biology. 31:77-85
(S)-2-(4'-[11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid ([11C]MSMA) and N-hydroxy-(R)-2-[[(4'-[11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide ([11C]CGS 25966), carbon-11 labeled matrix metalloproteinase (MMP) inhibitors, have
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3933-3938
Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) were prepared by nuc
Autor:
Qi-Huang Zheng, Xiangshu Fei, Timothy R DeGrado, Ji-Quan Wang, K Lee Stone, Tanya D Martinez, Dawn J Gay, Winston L Baity, Bruce H Mock, Barbara E Glick-Wilson, Michael L Sullivan, Kathy D Miller, George W Sledge, Gary D Hutchins
Publikováno v:
Nuclear Medicine and Biology. 30:753-760
(2R)-2-[[4-(6-fluorohex-1-ynyl)phenyl]sulfonylamino]-3-methylbutyric acid [(11)C]methyl ester ([(11)C]FMAME), a novel carbon-11 labeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission t