Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Xiangshi Tan"'
Publikováno v:
Annals of Medicine, Vol 55, Iss 1 (2023)
AbstractBackground With high recurrence and metastatic rates, triple-negative breast cancer (TNBC) has few therapy choices. The innate immune stimulator of interferon genes protein (STING) pathway has emerged as a critical foundation for improving an
Externí odkaz:
https://doaj.org/article/859e7e92eeec43aaa8ef755eb44dc431
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The role of cGAMP stimulating cGAS-cGAMP-STING-IRF3 pathway to inhibit tumor growth was well-established. Herein, the efficiency and pharmacological mechanism of cGAMP on regulating tumor metastasis was investigated. The effects of cGAMP regulating C
Externí odkaz:
https://doaj.org/article/3c389ced9bae412aa73e09f0bbb7e95c
Autor:
Yang Xiang, Yue-Juan Zhang, Ying Ge, Yajun Zhou, Cheng Chen, Weixiao Yuan Wahlgren, Xiangshi Tan, Xi Chen, Ke-Wu Yang
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 72 (2020)
Inhibition of β-lactamases presents a promising strategy to restore the β-lactams antibacterial activity to resistant bacteria. In this work, we found that aromatic carboxyl substituted 2-triazolylthioacetamides 1a−j inhibited VIM-2, exhibiting a
Externí odkaz:
https://doaj.org/article/89087979630147f5b60c6b5fa601368e
Autor:
Wenxian Lan, Zhonghua Wang, Zhongzheng Yang, Tianlei Ying, Xu Zhang, Xiangshi Tan, Maili Liu, Chunyang Cao, Zhong-Xian Huang
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107305 (2014)
The catalytic activity of cytochrome c (cyt c) to peroxidize cardiolipin to its oxidized form is required for the release of pro-apoptotic factors from mitochondria, and for execution of the subsequent apoptotic steps. However, the structural basis f
Externí odkaz:
https://doaj.org/article/9d23331e85b8408fb13d1d4a9eb30d75
Autor:
Wenxian Lan, Zhonghua Wang, Zhongzheng Yang, Jing Zhu, Tianlei Ying, Xianwang Jiang, Xu Zhang, Houming Wu, Maili Liu, Xiangshi Tan, Chunyang Cao, Zhong-Xian Huang
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27219 (2011)
To convert cyt c into a peroxidase-like metalloenzyme, the P71H mutant was designed to introduce a distal histidine. Unexpectedly, its peroxidase activity was found even lower than that of the native, and that the axial ligation of heme iron was chan
Externí odkaz:
https://doaj.org/article/c3757a2a4ad44e8c9c0077fd8210a03c
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2010 (2010)
Neuronal growth inhibitory factor (GIF), also known as metallothionein (metallothionein-3), impairs the survival and neurite formation of cultured neurons. It is known that the α-β domain-domain interaction of hGIF is crucial to the neuron growth i
Externí odkaz:
https://doaj.org/article/82ef34133eb04a54b162de3131a0e278
Publikováno v:
RSC Chemical Biology. 4:330-333
An engineered T67C myoglobin mutant undergoes self-oxidation of Cys67 to a sulfinic acid (Cys–SO2H), as confirmed by the X-ray crystal structure, which provides a useful platform to generate artificial proteins by further chemical modifications.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3813fc6a59550697b7360c44cfdd51ff
https://doi.org/10.1039/d3cb00007a
https://doi.org/10.1039/d3cb00007a
Publikováno v:
Biochemical and Biophysical Research Communications. 598:26-31
Globins are heme proteins such as hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb), playing important roles in biological system. In addition to normal functions, zebrafish Ngb was able to penetrate cell membranes, whereas less was known for oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499932c429ad9283cc35997f1dd3e051
https://doi.org/10.1016/j.bbrc.2022.02.013
https://doi.org/10.1016/j.bbrc.2022.02.013
Publikováno v:
European Journal of Inorganic Chemistry. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a37f11975573bb1d4147d777de4f7c9
https://doi.org/10.1002/ejic.202200727
https://doi.org/10.1002/ejic.202200727
