Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Xiangru Lu"'
Autor:
Brent J. Tschirhart, Xiangru Lu, Aristide Laurel Mokale Kognou, Claudio M. Martin, Marat Slessarev, Douglas D. Fraser, Aleksandra Leligdowicz, Bradley Urquhart, Qingping Feng
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Objective: Annexin A5 is a phosphatidylserine binding protein with anti-inflammatory, anticoagulant and anti-apoptotic properties. Preclinical studies have shown that annexin A5 inhibits pro-inflammatory responses and improves organ function and surv
Externí odkaz:
https://doaj.org/article/30877719cec04799b7f2811b1ee78d86
Autor:
Claudio M. Martin, MD, Marat Slessarev, MD, PhD, Eileen Campbell, John Basmaji, MD, Ian Ball, MD, Douglas D. Fraser, MD, PhD, Aleksandra Leligdowicz, MD, PhD, Tina Mele, MD, PhD, Fran Priestap, MSc, Brent J. Tschirhart, MSc, Tracey Bentall, RN, Xiangru Lu, MD, Qingping Feng, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 10, p e0986 (2023)
OBJECTIVES:. To evaluate the study design and feasibility of drug administration and safety in a randomized clinical trial of recombinant human annexin A5 (SY-005), a constitutively expressed protein with anti-inflammatory, antiapoptotic, and anticoa
Externí odkaz:
https://doaj.org/article/f02c7cacc2d4428e8e38bedbb729b0c7
Autor:
Brent J. Tschirhart, Xiangru Lu, Janice Gomes, Arundhasa Chandrabalan, Gillian Bell, David A. Hess, Guangxin Xing, Hong Ling, Dylan Burger, Qingping Feng
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 837 (2023)
Sepsis is caused by a dysregulated immune response to infection and is a leading cause of mortality globally. To date, no specific therapeutics are available to treat the underlying septic response. We and others have shown that recombinant human ann
Externí odkaz:
https://doaj.org/article/ecf56b9a0f834f0e975f87e24fd79aa6
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 3, p 29 (2021)
Background: Left ventricular noncompaction (LVNC) is a cardiomyopathy that can lead to arrhythmias, embolic events and heart failure. Despite our current knowledge of cardiac development, the mechanisms underlying noncompaction of the ventricular myo
Externí odkaz:
https://doaj.org/article/1e66db00280c4c2ebbef80895751e837
Autor:
Anish Engineer, Tana Saiyin, Xiangru Lu, Andrew S. Kucey, Brad L. Urquhart, Thomas A. Drysdale, Kambiz Norozi, Qingping Feng
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 21 (2018)
Background Tetrahydrobiopterin is a cofactor of endothelial NO synthase (eNOS), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS unc
Externí odkaz:
https://doaj.org/article/ba7bdb957fe64365831928468b87e8f0
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundThe small GTPase Rac1 regulates diverse cellular functions, including both apicobasal and planar cell polarity pathways; however, its role in cardiac outflow tract (OFT) development remains unknown. In the present study, we aimed to examine
Externí odkaz:
https://doaj.org/article/042907a53d3c46a9861c30d0d997d988
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77611 (2013)
Nitric oxide synthase-3 (NOS3) has recently been shown to promote endothelial-to-mesenchymal transition (EndMT) in the developing atrioventricular (AV) canal. The present study was aimed to investigate the role of NOS3 in embryonic development of AV
Externí odkaz:
https://doaj.org/article/bc71777eb8e6453ba9b29c69272152c2
Autor:
Tschirhart, Brent J., Xiangru Lu, Mokale Kognou, Aristide Laurel, Martin, Claudio M., Slessarev, Marat, Fraser, Douglas D., Leligdowicz, Aleksandra, Urquhart, Bradley, Qingping Feng
Publikováno v:
Frontiers in Pharmacology; 2024, p1-8, 8p
Publikováno v:
Cannabis & Cannabinoid Research; Feb2024, Vol. 9 Issue 1, p121-133, 13p
Autor:
Feng, Brent J. Tschirhart, Xiangru Lu, Janice Gomes, Arundhasa Chandrabalan, Gillian Bell, David A. Hess, Guangxin Xing, Hong Ling, Dylan Burger, Qingping
Publikováno v:
Pharmaceuticals; Volume 16; Issue 6; Pages: 837
Sepsis is caused by a dysregulated immune response to infection and is a leading cause of mortality globally. To date, no specific therapeutics are available to treat the underlying septic response. We and others have shown that recombinant human ann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::107f283b7b42d9fe8666ed91cc4df027