Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Xiangrao Li"'
Autor:
Yue Li, Siyuan Fan, Lingyao Kong, Zhenxuan Hao, Yanjun Zhou, Jiahong Shangguan, Lu Gao, Mingdan Wang, Yue Kang, Xiangrao Li, Kun Huang, Chao Zhang, Zhibo Liu
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108070- (2023)
Summary: CD9 is a member of the tetraspanin protein family, which has been widely studied in inflammation and cancer, but not in pathological cardiac hypertrophy. In this study, we found that the expression of CD9 was increased in transaortic constri
Externí odkaz:
https://doaj.org/article/5c77285570994ad0a1742ebab8f00fb1
Publikováno v:
Immunity, Inflammation and Disease, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract Background Reperfusion therapy is the most effective approach to resolve coronary occlusion, but myocardial injury caused by excessive inflammation during myocardial ischemia–reperfusion will also pose a new threat to health. Our prior stu
Externí odkaz:
https://doaj.org/article/26166c1a4e1045419432a73b5edf697d
Autor:
Meng Du, Lin Yuan, Xin Tan, Dandan Huang, Xiaojing Wang, Zhe Zheng, Xiaoxiang Mao, Xiangrao Li, Liu Yang, Kun Huang, Fengxiao Zhang, Yan Wang, Xi Luo, Dan Huang, Kai Huang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Excessive inflammation can be tissue destructive and contributes to auotinflammatory diseases and sepsis pathology. Here the authors show that the lncRNA Mirt2 is an endogenous negative feedback regulator of LPS-induced inflammation by limiting ubiqu
Externí odkaz:
https://doaj.org/article/9559c18bd2b8412bb18a884595349028
Publikováno v:
Cellular Physiology and Biochemistry, Vol 42, Iss 3, Pp 1153-1164 (2017)
Background/Aims: The expression of a novel lncRNA, myocardial infarction associated transcript 1(Mirt1), has been shown to be upregulated in acute myocardial infarction (AMI). However, the role of Mirt1 in AMI is not clear. Methods: In this study, we
Externí odkaz:
https://doaj.org/article/f0aa76821cd64eab9e8432f4596bc1f0
Autor:
Meng Du, Xiaojing Wang, Xin Tan, Xiangrao Li, Dandan Huang, Kun Huang, Liu Yang, Fengxiao Zhang, Yan Wang, Dan Huang, Kai Huang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 12 (2016)
BackgroundNK2 homeobox 5 (Nkx2‐5) is a cardiac homeobox transcription factor that is expressed in a broad range of cardiac sublineages. Embryos lacking Nkx2‐5 are nonviable attributed to growth retardation and gross abnormalities of the heart. Ho
Externí odkaz:
https://doaj.org/article/a46ddbbebb85434799f6fcbbd8eb3320
Autor:
Liu Yang, Kun Huang, Xiangrao Li, Meng Du, Xiang Kang, Xi Luo, Lu Gao, Cheng Wang, Yanqing Zhang, Chun Zhang, Qiangsong Tong, Kai Huang, Fengxiao Zhang, Dan Huang
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82872 (2013)
The transcription factor Sp1 is implicated in the activation of G0/G1 phase genes. Modulation of Sp1 transcription activities may affect G1-S checkpoint, resulting in changes in cell proliferation. In this study, our results demonstrated that activat
Externí odkaz:
https://doaj.org/article/bacbc70b73a746b99aea68856245a2eb
Autor:
Yue Li, Kun Huang, Lingyao Kong, Zhenxuan Hao, Yanjun Zhou, Jiahong Shangguan, Lu Gao, Mingdan Wang, Yue Kang, Xiangrao Li, Chao Zhang, Zhibo Liu
Pathological myocardial hypertrophy is a common cardiovascular disease that can progress to heart failure. At present, there is no ideal therapeutic drug in clinical practice. This study aimed to find new therapeutic targets for pathological myocardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e1bf1a784eddec8111c6929ed270bb7
https://doi.org/10.21203/rs.3.rs-2004988/v1
https://doi.org/10.21203/rs.3.rs-2004988/v1
Autor:
Min Cheng, Ling Yang, Xin Tan, Xiangrao Li, Feng Zhu, Lin Wang, Qinglin Yang, Cheng Wang, Liqing Yu, Meng Du, Fengxiao Zhang, Kai Huang, Dan Huang, Kun Huang, Yuhan Jiang
Publikováno v:
J Hepatol
Background & Aims PARP1 is a key mediator of cellular stress responses and critical in multiple physiological and pathophysiological processes of cells. However, whether it is involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Autor:
Dan Sun, Fengxiao Zhang, Lizhi Hu, Xiaoxiang Mao, Xiangrao Li, Xin Tan, Zhiping Shu, Meng Du, Kai Huang, Shan Deng, Long Chen
Publikováno v:
Diabetes
CCR2 has been proven to play an important role in diabetes. However, the role of CCR2 in diabetic cardiomyopathy has not been examined. In this study, we investigated the effects of cardiac CCR2 on diabetic cardiomyopathy. We created a model of strep
Autor:
Kun Huang, Liu Yang, Xiangrao Li, Fengxiao Zhang, Dan Huang, Zhe Zheng, Xiaojing Wang, Xiaoxiang Mao, Xi Luo, Kai Huang, Meng Du, Lin Yuan, Dandan Huang, Yan Wang, Xin Tan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Nature Communications
Nature Communications
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRR) with a crucial function in innate immune responses. Activation of TLR4 signaling at the plasma membrane by lipopolysaccharide (LPS) stimulates proinflammatory signaling pa