Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Xiangqing Xu"'
Autor:
Yaqin Wei, Xiangqing Xu, Qiang Guo, Song Zhao, Yinli Qiu, Dongli Wang, Wenwen Yu, Yani Liu, KeWei Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1457-1466 (2024)
Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving cognition. In this study, we report a novel dual serotonin transporter and voltage
Externí odkaz:
https://doaj.org/article/cf0330df67fe4f62ac13a4b229aaf901
Autor:
Zhongtang Li, Fan Fang, Yiyan Li, Xuehui Lv, Ruqiu Zheng, Peili Jiao, Yuxi Wang, Guiwang Zhu, Zefang Jin, Xiangqing Xu, Yinli Qiu, Guisen Zhang, Zhongjun Li, Zhenming Liu, Liangren Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4553-4577 (2023)
Dopamine D3 receptor (D3R) is implicated in multiple psychotic symptoms. Increasing the D3R selectivity over dopamine D2 receptor (D2R) would facilitate the antipsychotic treatments. Herein, novel carbazole and tetrahydro-carboline derivatives were r
Externí odkaz:
https://doaj.org/article/08553c6ed9fd4efaa867b3079b9ecb63
Autor:
Zijin Feng, Zhijing Hu, Lei Li, Minquan Yu, Yiting Zhang, Peng Jing, Xiangqing Xu, Jinhui Wu, Yiqiao Hu, Xiangyang Xu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Schizophrenia is a serious psychiatric disorder that significantly affects the quality of life of patients. The objective of this study is to discover a novel antipsychotic candidate with highly antagonistic activity against both serotoni
Externí odkaz:
https://doaj.org/article/a96fac045228435e8ff0883329a4967b
Autor:
Yuxi Wang, Jian Gao, Song Zhao, Yan Song, Han Huang, Guiwang Zhu, Peili Jiao, Xiangqing Xu, Guisen Zhang, Kewei Wang, Liangren Zhang, Zhenming Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1947-1964 (2021)
Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarbox
Externí odkaz:
https://doaj.org/article/65a6ec1bc8c447e5ae90d1f9ab335c92
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Neuropathic pain is mainly triggered after nerve injury and associated with plasticity of the nociceptive pathway in primary sensory neurons. Currently, the treatment remains a challenge. In order to identify specific therapeutic targets, it is neces
Externí odkaz:
https://doaj.org/article/d6fa3f48e44f4a2bb60c5b529be8d464
Autor:
Sishuo Zhang, Yahan Wang, Haitao Li, Hongwei Zhi, Xixi Zhai, Wenting Ruan, Shuai Zhang, Xiangqing Xu, Hongyun Wu
Publikováno v:
Biotechnology and Genetic Engineering Reviews. :1-16
Autor:
Xiao-jun Chen, Yao Huang, Shuguang Yuan, Yachun Han, Zheng Li, Xiangqing Xu, Xiao Fu, Fenghua Peng, Sanyong Zhang, Liuxia Xiang, Kewen Shi, Xinyuan Cui, Zurong Zhang, Jinying Wei, Shiyu Xia, Yang Xiao, Lin Sun, Hong Liu, Xuejing Zhu
Publikováno v:
Postgraduate Medical Journal; Jan2024, Vol. 100 Issue 1179, p20-27, 8p
Autor:
Hao Hua, Chaoli Huang, Hanyu Liu, Xiangyang Xu, Xiangqing Xu, Zifeng Wu, Cunming Liu, Yuanyuan Wang, Chun Yang
Publikováno v:
Neuropharmacology. 220
The discovery of the robust antidepressant actions of ketamine is regarded as one of the greatest advancements in depression treatment in the past 60 years. Recent findings have provided strong evidence for the presence of bidirectional communication
Autor:
Fan Fang, Zhenming Liu, Guanxing Cai, Liangren Zhang, Xiangqing Xu, Zhongjun Li, Minghua Fan, Wenchao Li, Yiyan Li, Zhuo Huang, Zhongtang Li, Guisen Zhang, Yinli Qiu, Yuxi Wang, Xuehui Lv, Jingjing Lian, Ruqiu Zheng
Publikováno v:
Journal of Medicinal Chemistry. 64:5551-5576
N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated Na+ and Ca2+-permeable ion channels involved in excitatory synaptic transmission and synaptic plasticity. NMDAR hypofunction has long been implicated in the pathophysiology including major d
Autor:
Teng He, Di Wang, Zifeng Wu, Chaoli Huang, Xiangyang Xu, Xiangqing Xu, Cunming Liu, Kenji Hashimoto, Chun Yang
Publikováno v:
Neuropharmacology. 218:109207
Anesthetic ketamine is a racemic mixture containing equal amount of (R)-ketamine and (S)-ketamine. Increasing preclinical data show that (R)-ketamine has a rapid-onset and sustained antidepressant without significant side effects. There are currently