Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Xiangmin Peng"'
Publikováno v:
Journal of Neurochemistry. 119:1183-1193
Nogo-A and its cognate receptor NogoR1 (NgR1) are both expressed in neurons. To explore the function of these proteins in neurons of the CNS, we carried out a series of studies using postnatal hippocampal neurons in culture. Interfering with the bind
Publikováno v:
Pain. 151:296-306
Neuropathic pain is accompanied by neuroimmune activation in dorsal horn of spinal cord. We have observed that in animal models this activation is characterized by an increased expression of transmembrane tumor necrosis factor α (mTNFα) without the
Publikováno v:
Journal of Biological Chemistry. 285:2783-2795
Nogo-A, a member of the reticulon family, is present in neurons and oligodendrocytes. Nogo-A in central nervous system (CNS) myelin prevents axonal regeneration through interaction with Nogo receptor 1, but the function of Nogo-A in neurons is less k
Publikováno v:
Experimental Neurology. 220:183-190
We have previously reported that the anti-inflammatory cytokine IL-10 induces a number of signaling cascades through the IL-10 receptor in spinal cord neurons in vitro to activate NF-kappaB transcription Bcl-2 and Bcl-x(L) and that, after exposure to
Publikováno v:
Journal of Neurochemistry. 110:1617-1627
Interleukin (IL)-10, a prototypical anti-inflammatory cytokine, has been shown to provide beneficial effects in neuronal injury in vivo but the full range of actions has not been established. In order to understand the neuronal mechanisms underlying
Publikováno v:
Molecular Therapy. 17:1173-1179
Artemin is a neurotrophic factor of the glial cell line-derived neurotrophic factor (GDNF) family of ligands that acts through the GDNF family receptor alpha3 (GFRalpha3)/ret receptor found predominantly on sensory and sympathetic neurons. In order t
Publikováno v:
Gene Therapy. 15:183-190
To dissect the molecular basis of the neuroimmune response associated with the genesis of inflammatory (nociceptive) pain, we constructed a herpes simplex virus-based gene transfer vector to express the antiinflammatory cytokine interleukin-10 (IL-10
Autor:
Xiankui Sun, David J. Fink, Xiangmin Peng, Zhigang Zhou, Peipei Chiang, Marina Mata, Jeeyong Kim
Publikováno v:
Experimental neurology. 237(1)
Although surgical re-implantation of spinal roots may improve recovery of proximal motor function after cervical root avulsion, recovery of sensory function necessary for fine motor coordination of the hand has been difficult to achieve, in large par
Publikováno v:
Journal of neurochemistry. 119(6)
Nogo-A and its cognate receptor NogoR1 (NgR1) are both expressed in neurons. In order to explore the function of these proteins in neurons of the central nervous system, we carried out a series of studies using postnatal hippocampal neurons in cultur
Rho GTPase regulation of α-synuclein and VMAT2: implications for pathogenesis of Parkinson's disease
Publikováno v:
Molecular and cellular neurosciences. 48(1)
Accumulation of α-synuclein (Asyn) in neuronal perikarya and dystrophic neurites is characteristic of idiopathic and familial Parkinson’s disease. In this study, we investigated the relationship between α-synuclein expression and neurite outgrowt