Výsledky vyhledávání - "Xiangmeng Wu"

Akademický článek

Cholesterol-modified sphingomyelin chimeric lipid bilayer for improved therapeutic delivery

Autor: Zhiren Wang, Wenpan Li, Yanhao Jiang, Jonghan Park, Karina Marie Gonzalez, Xiangmeng Wu, Qing-Yu Zhang, Jianqin Lu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Cholesterol (Chol) fortifies packing and reduces fluidity and permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery. However, under the physiological environment, Chol is rapidly extracted from the lipid bilayer by

Externí odkaz: https://doaj.org/article/b643c24fdd054481a3ec106bc7be1c95

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Akademický článek

A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases

Autor: Subodh Kumar Samrat, Qamar Bashir, Ran Zhang, Yiding Huang, Yuchen Liu, Xiangmeng Wu, Tyler Brown, Wei Wang, Y. George Zheng, Qing-Yu Zhang, Yin Chen, Zhong Li, Hongmin Li

Publikováno v: Emerging Microbes and Infections, Vol 12, Iss 1 (2023)

ABSTRACTSARS-CoV-2 has caused a global pandemic with significant humanity and economic loss since 2020. Currently, only limited options are available to treat SARS-CoV-2 infections for vulnerable populations. In this study, we report a universal fluo

Externí odkaz: https://doaj.org/article/60c51fd2806c487b8bf9c42761d4bf04

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Akademický článek

In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus

Autor: Zhong Li, Jimin Xu, Yuekun Lang, Xiangmeng Wu, Saiyang Hu, Subodh Kumar Samrat, Anil M. Tharappel, Lili Kuo, David Butler, Yongcheng Song, Qing-Yu Zhang, Jia Zhou, Hongmin Li

Publikováno v: Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1662-1670 (2022)

Zika virus (ZIKV) causes significant human diseases without specific therapy. Previously we found erythrosin B, an FDA-approved food additive, inhibited viral NS2B−NS3 interactions, leading to inhibition of ZIKV infection in cell culture. In this s

Externí odkaz: https://doaj.org/article/825f512a044d416aad86d0b0d67c9f7d

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Akademický článek

Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses

Autor: C. Joaquín Cáceres, Yanmei Hu, Stivalis Cárdenas-García, Xiangmeng Wu, Haozhou Tan, Silvia Carnaccini, L. Claire Gay, Ginger Geiger, Chunlong Ma, Qing-Yu Zhang, Daniela Rajao, Daniel R. Perez, Jun Wang

Publikováno v: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1832-1848 (2021)

Seasonal influenza A virus (IAV) infections are among the most important global health problems. FDA-approved antiviral therapies against IAV include neuraminidase inhibitors, M2 inhibitors, and polymerase inhibitor baloxavir. Resistance against adam

Externí odkaz: https://doaj.org/article/bca2a8c909e4481fa1b4630958e72308

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Akademický článek

Differential Effects of Arsenic in Drinking Water on Mouse Hepatic and Intestinal Heme Oxygenase-1 Expression

Autor: Hui Li, Xiaoyu Fan, Xiangmeng Wu, Weiguo Han, Mary Kay Amistadi, Pengfei Liu, Donna Zhang, Jon Chorover, Xinxin Ding, Qing-Yu Zhang

Publikováno v: Antioxidants, Vol 11, Iss 9, p 1835 (2022)

Arsenic exposure has been associated with the risks of various diseases, including cancers and metabolic diseases. The aim of this study was to examine the effects of arsenic exposure via drinking water on the expression of heme oxygenase-1 (HO-1), a

Externí odkaz: https://doaj.org/article/e5da438c27ba495daa343a55509e7387

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Akademický článek

Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol

Autor: Xiangmeng Wu, Qinghao Zhang, Jiamei Guo, Yufei Jia, Ziqian Zhang, Manman Zhao, Yakun Yang, Baolian Wang, Jinping Hu, Li Sheng, Yan Li

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

10-Chloromethyl-11-demethyl-12-oxo-calanolide (F18), an analog of calanolide A, is a novel potent nonnucleoside reverse transcriptase inhibitor against HIV-1. Here, we report the metabolic profile and the results of associated biochemical studies of

Externí odkaz: https://doaj.org/article/5ff514a7155841f7b5b419cfcb06a26c

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Akademický článek

Stereoselective property of 20(S)-protopanaxadiol ocotillol type epimers affects its absorption and also the inhibition of P-glycoprotein.

Autor: Wenyan Wang, Xiangmeng Wu, Li Wang, Qingguo Meng, Wanhui Liu

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98887 (2014)

Stereoselectivity has been proved to be tightly related to drug action including pharmacodynamics and pharmacokinetics. (20S,24R)-epoxy-dammarane-3,12,25-triol (24R-epimer) and (20S,24S)-epoxy-dammarane-3,12,25-triol (24S-epimer), a pair of 20(S)-pro

Externí odkaz: https://doaj.org/article/356fbdc92ece41baa4ccf7eb300a637d

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