Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Xiangliang Yuan"'
Autor:
Danfeng Dong, Yuzhang Du, Xuefeng Fei, Hao Yang, Xiaofang Li, Xiaobao Yang, Junrui Ma, Shu Huang, Zhihui Ma, Juanjuan Zheng, David W. Chan, Liyun Shi, Yunqi Li, Aaron T. Irving, Xiangliang Yuan, Xiangfan Liu, Peihua Ni, Yiqun Hu, Guangxun Meng, Yibing Peng, Anthony Sadler, Dakang Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Inflammasome activity is important for the immune response and is instrumental in numerous clinical conditions. Here we identify a mechanism that modulates the central Caspase-1 and NLR (Nod-like receptor) adaptor protein ASC (apoptosis-asso
Externí odkaz:
https://doaj.org/article/7f19608cb89141d283f2dcd9b36f3fb4
Autor:
Naisheng Zheng, Tingting Wang, Qin Luo, Yi Liu, Junyao Yang, Yunlan Zhou, Guohua Xie, Yanhui Ma, Xiangliang Yuan, Lisong Shen
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTT-cell-based immune checkpoint blockade therapy (ICB) can be undermined by local immunosuppressive M2-like tumor-associated macrophages (TAMs). However, modulating macrophages has proved difficult as the molecular and functional features of M
Externí odkaz:
https://doaj.org/article/59a2faa4c9524846b16d51ea577bfc7a
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/a7810022b49b4131bcd0dbc371abc1d1
Autor:
Lei Zhang, Li Jiang, Liang Yu, Qin Li, Xiangjun Tian, Jingquan He, Ling Zeng, Yuqin Yang, Chaoran Wang, Yuhan Wei, Xiaoyue Jiang, Jing Li, Xiaolu Ge, Qisheng Gu, Jikun Li, Di Wu, Anthony J. Sadler, Di Yu, Dakang Xu, Yue Gao, Xiangliang Yuan, Baokun He
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The metabolic environment of tumours has wide-ranging effects on the anti-tumour immune response and the outcome of immune therapy. Authors show here that the purine metabolite inosine enhances tumour immunogenicity and thus immune checkpoint blockad
Externí odkaz:
https://doaj.org/article/852722dd37b04979b5df24d84b26d42c
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-20 (2022)
Abstract The gut microbiota have long been recognized to play a key role in human health and disease. Currently, several lines of evidence from preclinical to clinical research have gradually established that the gut microbiota can modulate antitumor
Externí odkaz:
https://doaj.org/article/8106a16fc5014d688a004f4da00ba84b
Autor:
Yuhan Wei, Jianwei Zhang, Xueke Fan, Zhi Zheng, Xiaoyue Jiang, Dexi Chen, Yuting Lu, Yingrui Li, Miao Wang, Min Hu, Qi Du, Liuting Yang, Hongzhong Li, Yi Xiao, Yongfu Li, Jiangtao Jin, Deying Wang, Xiangliang Yuan, Qin Li
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The profiling of the tumor immune microenvironment (TIME) is critical for guiding immunotherapy strategies. However, how the composition of the immune landscape affects the tumor progression of gastric cancer (GC) is ill-defined. Here, we used mass c
Externí odkaz:
https://doaj.org/article/29dc5b6254084f268888c312d4cfd712
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The immunosuppressive status of the tumor microenvironment (TME) remains poorly defined due to a lack of understanding regarding the function of tumor-associated macrophages (TAMs), which are abundant in the TME. TAMs are crucial drivers of tumor pro
Externí odkaz:
https://doaj.org/article/b663f072f50e43ee89a75025089a4a6e
Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry
Autor:
Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R. G. Williams, David W. Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu, Yiqun Hu
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-11 (2017)
Abstract Background Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses. Methods We developed a
Externí odkaz:
https://doaj.org/article/f6edff3e5094408bad4552f74bad6a20
Autor:
Peiming Zheng, Lei Chen, Xiangliang Yuan, Qin Luo, Yi Liu, Guohua Xie, Yanhui Ma, Lisong Shen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-13 (2017)
Abstract Background Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates that tumor-associated
Externí odkaz:
https://doaj.org/article/3101e5ab487d47babb6ffbb38eab6ce1
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Immune checkpoint blockade (ICB) immunotherapy increases antitumor immunity by blocking cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4) or programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) and displays robust clinical resp
Externí odkaz:
https://doaj.org/article/90567a84c0874983ab47a9ff8839d4f6