Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Xianglian Ge"'
Autor:
Haihua Xie, Xianglian Ge, Fayu Yang, Bang Wang, Shuang Li, Jinzhi Duan, Xiujuan Lv, Congsheng Cheng, Zongming Song, Changbao Liu, Junzhao Zhao, Yu Zhang, Jinyu Wu, Caixia Gao, Jinwei Zhang, Feng Gu
Publikováno v:
PLoS Biology, Vol 18, Iss 7, p e3000747 (2020)
CRISPR-Staphylococcus aureus Cas9 (CRISPR-SaCas9) has been harnessed as an effective in vivo genome-editing tool to manipulate genomes. However, off-target effects remain a major bottleneck that precludes safe and reliable applications in genome edit
Externí odkaz:
https://doaj.org/article/46f2b5198ce1454aa7127860471039e6
Autor:
Fayu Yang, Changbao Liu, Ding Chen, Mengjun Tu, Haihua Xie, Huihui Sun, Xianglian Ge, Lianchao Tang, Jin Li, Jiayong Zheng, Zongming Song, Jia Qu, Feng Gu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 378-386 (2017)
Cre-loxP, as one of the site-specific genetic manipulation tools, offers a method to study the spatial and temporal regulation of gene expression/inactivation in order to decipher gene function. CRISPR/Cas9-mediated targeted genome engineering techno
Externí odkaz:
https://doaj.org/article/9567fa043f504c78ad6982f04c369414
Autor:
Ding Chen, Tao Xu, Mengjun Tu, Jinlin Xu, Chenchen Zhou, Lulu Cheng, Ruqing Yang, Tanchu Yang, Weiwei Zheng, Xiubin He, Ruzhi Deng, Xianglian Ge, Jin Li, Zongming Song, Junzhao Zhao, Feng Gu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2018)
X-linked juvenile retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding retinoschisin (RS1), which leads to a significant proportion of visual impairment and blindness. To develop personalized genome editing based gene th
Externí odkaz:
https://doaj.org/article/a524905c67804ac7bbcf941f0806b82c
Autor:
Yihua Yao, Xuedong Zheng, Xianglian Ge, Yanghui Xiu, Liu Zhang, Weifang Fang, Junzhao Zhao, Feng Gu, Yihua Zhu
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184440 (2017)
Autosomal dominant congenital cataract (ADCC) is a clinically and genetically heterogeneous ocular disease in children that results in serious visual impairments or even blindness. Targeted exome sequencing (TES) is an efficient method used for genet
Externí odkaz:
https://doaj.org/article/94095e6341334f768c8d3b93ed0726b4
Autor:
Xianglian Ge, Haitao Xi, Fayu Yang, Xiao Zhi, Yanghua Fu, Ding Chen, Ren-He Xu, Ge Lin, Jia Qu, Junzhao Zhao, Feng Gu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Clustered interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-mediated genome engineering technologies are sparking a new revolution in biological research. This technology efficiently induces DNA double strand breaks at
Externí odkaz:
https://doaj.org/article/118983d0f9424dff8022e64e5eaaed5c
Autor:
Xiao Zhang, Xianglian Ge, Wei Shi, Ping Huang, Qingjie Min, Minghan Li, Xinping Yu, Yaming Wu, Guangyu Zhao, Yi Tong, Zi-Bing Jin, Jia Qu, Feng Gu
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95528 (2014)
Stargardt Disease (STGD) is the commonest genetic form of juvenile or early adult onset macular degeneration, which is a genetically heterogeneous disease. Molecular diagnosis of STGD remains a challenge in a significant proportion of cases. To addre
Externí odkaz:
https://doaj.org/article/4078250f7fa84d8d90137345628028ac
Autor:
Yongchang Yang, Xingyu Jin, Yang Xie, Chunlan Ning, Yiding Ai, Haotian Wei, Xing Xu, Xianglian Ge, Tailong Yi, Qiang Huang, Xuejun Yang, Tao Jiang, Xiaoguang Wang, Yingzhe Piao, Xun Jin
Publikováno v:
Theranostics; 2024, Vol. 14 Issue 10, p4107-4126, 20p
Autor:
Xing, Xu, Yongchang, Yang, Yancheng, Liu, Xianglian, Ge, Tailong, Yi, Yang, Xie, Chunlan, Ning, Shengfu, Shen, Zengfeng, Sun, Zhen, Zhang, Qiongli, Zhai, Xiaoguang, Wang, Xianghui, Meng, Jun, Dong, Qiang, Huang, Xuejun, Yang, Wenliang, Li, Xun, Jin
Publikováno v:
Current Cancer Drug Targets. 23:400-411
Background: Stromal cells in the tumor microenvironment play crucial roles in glioma development. Current methods for isolating tumor-associated stromal cells (such as neutrophils) are inefficient due to the conflict between tissue dissociation and c
Autor:
Xun Jin, Yongchang Yang, Xing Xu, Yang Xie, Yancheng Liu, Chunlan Ning, Yiding Ai, Chao Lv, Haotian Wei, Xianglian Ge, Tailong Yi, Yongjun Piao, Xiaoguang Wang
Publikováno v:
Current Pharmaceutical Design. 28:2189-2202
Background: Glioma is the most common malignant intracranial tumor with high lethality. Despite surgery combined with chemoradiotherapy, the prognosis for patients with glioma remains poor. This is primarily due to acquired chemoradiotherapy resistan
Autor:
Yongchang, Yang, Xing, Xu, Yang, Xie, Yancheng, Liu, Chunlan, Ning, Yiding, Ai, Chao, Lv, Haotian, Wei, Xianglian, Ge, Tailong, Yi, Yongjun, Piao, Xiaoguang, Wang, Xun, Jin
Publikováno v:
Current pharmaceutical design. 28(26)
Glioma is the most common malignant intracranial tumor with high lethality. Despite surgery combined with chemoradiotherapy, the prognosis for patients with glioma remains poor. This is primarily due to acquired chemoradiotherapy resistance. Therefor