Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Xiangkai Ji"'
Autor:
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A. Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X. Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract HIV-1 reverse transcriptase is one of the most attractive targets for the treatment of AIDS. However, the rapid emergence of drug-resistant strains and unsatisfactory drug-like properties seriously limit the clinical application of HIV-1 non
Externí odkaz:
https://doaj.org/article/c38865deec50478fa334e921f6a1050d
Autor:
Xiangkai Ji, Xiangyi Jiang, Chisa Kobayashi, Yujie Ren, Lide Hu, Zhen Gao, Dongwei Kang, Ruifang Jia, Xujie Zhang, Shujie Zhao, Koichi Watashi, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 18, p 5987 (2022)
Hepatitis B virus (HBV) capsid protein (Cp) is necessary for viral replication and the maintenance of viral persistence, having become an attractive target of anti-HBV drugs. To improve the water solubility of HBV capsid protein allosteric modulator
Externí odkaz:
https://doaj.org/article/1d9c774993254a6aa2d0692cfebd1d4b
Autor:
Xiangkai Ji, Jing Li, Prem Prakash Sharma, Xiangyi Jiang, Brijesh Rathi, Zhen Gao, Lide Hu, Dongwei Kang, Erik De Clercq, Simon Cocklin, Chuanfeng Liu, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 18, p 5995 (2022)
As a key structural protein, HIV capsid (CA) protein plays multiple roles in the HIV life cycle, and is considered a promising target for anti-HIV treatment. Based on the structural information of CA modulator PF-74 bound to HIV-1 CA hexamer, 18 nove
Externí odkaz:
https://doaj.org/article/97f7765db41045cbadc4b893f8b9bc68
Autor:
Ruifang Jia, Jiwei Zhang, Jian Zhang, Chiara Bertagnin, Anna Bonomini, Laura Guizzo, Zhen Gao, Xiangkai Ji, Zhuo Li, Chuanfeng Liu, Han Ju, Xiuli Ma, Arianna Loregian, Bing Huang, Peng Zhan, Xinyong Liu
Publikováno v:
Molecules, Vol 27, Iss 19, p 6426 (2022)
To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of novel boron-containing N-substituted oseltamivir derivatives were designed and synthesized to target the 150-cavity of neuraminidase (NA). In NA inhibitory ass
Externí odkaz:
https://doaj.org/article/31d58646425e4f5fae5d75af1d8c6889
Autor:
Xiangyi Jiang, Prem Prakash Sharma, Brijesh Rathi, Xiangkai Ji, Lide Hu, Zhen Gao, Dongwei Kang, Zhao Wang, Minghui Xie, Shujing Xu, Xujie Zhang, Erik De Clercq, Simon Cocklin, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Journal of Medical Virology. 94:5975-5986
Human immunodeficiency virus (HIV) capsid (CA) protein is a promising target for developing novel anti-HIV drugs. Starting from highly anticipated CA inhibitors PF-74, we used scaffold hopping strategy to design a series of novel 1,2,4-triazole pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb156db7c886743198b168215f00ca1e
https://doi.org/10.1002/jmv.28064
https://doi.org/10.1002/jmv.28064
Publikováno v:
Frontiers in Civil and Hydraulic Engineering, Volume 1 ISBN: 9781003344209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28242ac7809d366b2c7d4592bdfb6d3e
https://doi.org/10.1201/9781003344209-37
https://doi.org/10.1201/9781003344209-37
Autor:
Xinyong Liu, Peng Zhan, Zhao Wang, Xiangkai Ji, Kuo‐Hsiung Lee, Simon Cocklin, Chin Ho Chen, Jing Li, Xiangyi Jiang, Dongwei Kang, Alexej Dick, Prem Prakash Sharma, Brijesh Rathi
Publikováno v:
Bioorg Med Chem
The HIV-1 Capsid (CA) is considered as a promising target for the development of potent antiviral drugs, due to its multiple roles during the viral life cycle. Herein, we report the design, synthesis, and antiviral activity evaluation of series of no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8422df8ef691cacc0baf6a7dfb8a2e09
https://pubmed.ncbi.nlm.nih.gov/34562701
https://pubmed.ncbi.nlm.nih.gov/34562701