Výsledky vyhledávání

Identification of Human UMP/CMP Kinase 1 as Doxorubicin Binding Target Using Protein Microarray

Autor: Xiaohai Gong, Donghui Ma, Jian Jin, Caiwei Chen, Shuxian Chen, Xianghui Ye, Xu Wang, Yongfeng Fu, Junlong Cai, Yun Chen, Xunjia Cheng

Publikováno v: SLAS Discovery. 22:1007-1015

Doxorubicin (DOX) is a leading anthracycline drug with exceptional efficacy; however, little is known about the molecular mechanisms of its side effects, which include heart muscle damage, noncancerous cell death, and drug resistance. A total of 17,9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc07d04d00b5ace3b87a7084e677f506
https://doi.org/10.1177/2472555217707704

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Gemcitabine and Doxorubicin Combination Enhance the Cytotoxic Effect to Pancreatic Cancer Cells BxPC3 and PANC1 through UMP/CMP Kinase 1

Autor: Xianghui Ye, Jian Jin, Shuxian Chen, Xu Wang

Publikováno v: Journal of Biosciences and Medicines. :64-74

Background: Gemcitabine is a deoxycytidine analog, which is used as first-line agent for pancreatic cancer therapy, and its efficacy relied on its intracellular conversion to active triphosphate form. However, administration with gemcitabine still ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23a57760792d19616d832449c686c650
https://doi.org/10.4236/jbm.2017.510007

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