Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts

Autor: Martin Uhrbom, Lars Muhl, Guillem Genové, Jianping Liu, Henrik Palmgren, Ida Alexandersson, Fredrik Karlsson, Alex-Xianghua Zhou, Sandra Lunnerdal, Sonja Gustafsson, Byambajav Buyandelger, Kasparas Petkevicius, Ingela Ahlstedt, Daniel Karlsson, Leif Aasehaug, Liqun He, Marie Jeansson, Christer Betsholtz, Xiao-Rong Peng

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Cell identities are defined by intrinsic transcriptional networks and spatio-temporal environmental factors. Here, we explored multiple factors that contribute to the identity of adipose stem cells, including anatomic location, microvascular

Externí odkaz: https://doaj.org/article/1b79a0f896454151b3ae472ae9fc9feb

Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy

Autor: Alex-Xianghua Zhou, Marie Jeansson, Liqun He, Leif Wigge, Pernilla Tonelius, Ramesh Tati, Linda Cederblad, Lars Muhl, Martin Uhrbom, Jianping Liu, Anna Björnson Granqvist, Lilach O. Lerman, Christer Betsholtz, Pernille B. L. Hansen

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 8, p 4320 (2024)

Endothelial cell (EC) injury is a crucial contributor to the progression of diabetic kidney disease (DKD), but the specific EC populations and mechanisms involved remain elusive. Kidney ECs (n = 5464) were collected at three timepoints from diabetic

Externí odkaz: https://doaj.org/article/4b92f51ce8dd424b94f406e3b18737c6

Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction.

Autor: Sara F Hansson, Alex-Xianghua Zhou, Paulina Vachet, Jan W Eriksson, Maria J Pereira, Stanko Skrtic, Helen Jongsma Wallin, Anders Ericsson-Dahlstrand, Daniel Karlsson, Andrea Ahnmark, Maria Sörhede Winzell, Maria Chiara Magnone, Pia Davidsson

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0196601 (2018)

Beta cell dysfunction accompanies and drives the progression of type 2 diabetes mellitus (T2D), but there are few clinical biomarkers available to assess islet cell stress in humans. Secretagogin, a protein enriched in pancreatic islets, demonstrates

Externí odkaz: https://doaj.org/article/9ceaca4506cf4aae8dab9aeb64a7c0da

The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation

Autor: Ali M. Tabish, Elke Ericson, Björn Tyrberg, David M. Smith, Chandrasekhar Kanduri, Hanne Scholz, Shadab Abadpour, Tanmoy Mondal, Ralph Knöll, Magnus Althage, Alex Xianghua Zhou

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 320:E846-E857

The discovery that long noncoding RNA TUNAR regulates β-cell proliferation may be important in designing new treatments for diabetes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::050406a2c02101242d45851c14853faa
https://doi.org/10.1152/ajpendo.00335.2020

Direct Drug Delivery to Kidney via the Renal Artery

Autor: Camilla Enggaard, Ulrika Dahlqvist, Jane Stubbe, Anna Björnson Granqvist, Magnus Söderberg, Alex-Xianghua Zhou, Tajana Tesan Tomic, Lena William-Olsson, Anette Ericsson

Publikováno v: Dahlqvist, U, Tomic, T T, Söderberg, M, Stubbe, J, Enggaard, C, Ericsson, A & Zhou, A-X 2021, ' Direct Drug Delivery to Kidney via the Renal Artery ', Journal of Visualized Experiments, vol. 170, e61932 . https://doi.org/10.3791/61932

There is a need for directed injections to enable increased and specific renal exposure for efficient evaluation of drug targets in the renal research field. Accumulation of drugs in certain organs may give rise to adverse and unwanted effects, depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b775e51d215091f9b7648d94835b0bc
https://doi.org/10.3791/61932-v