Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Xianghu Qu"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Throughout the continuum of heart formation, myocardial growth and differentiation occurs in concert with the development of a specialized population of endothelial cells lining the cardiac lumen, the endocardium. Once the endocardial cells are speci
Externí odkaz:
https://doaj.org/article/688d4a3f41ec471e9d632cda3e4b19a7
Autor:
Soniya Savant, Silvia La Porta, Annika Budnik, Katrin Busch, Junhao Hu, Nathalie Tisch, Claudia Korn, Aida Freire Valls, Andrew V. Benest, Dorothee Terhardt, Xianghu Qu, Ralf H. Adams, H. Scott Baldwin, Carmen Ruiz de Almodóvar, Hans-Reimer Rodewald, Hellmut G. Augustin
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1761-1773 (2015)
Tie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor. Yet, Tie1 deletion is embryonic lethal and Tie1 has been implicated in critical vascular pathologies, including atherosclerosis and tumor angiogenesis. Her
Externí odkaz:
https://doaj.org/article/8a8bd19bf7e943c8ba49e7bf3501a59e
Autor:
Xianghu Qu, Deqiang Li, Chen-Leng Cai, Megan Sweet, Fuxue Chen, Xiangqin He, Donghua Hu, Jiliang Zhou, Fan Yang, Christina Sanchez, Weinian Shou, Lu Zhang, Kunzhe Dong, Jian Ruan, Jian Shen
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41:815-821
Objective: Myh11 encodes a myosin heavy chain protein that is specifically expressed in smooth muscle cells (SMCs) and is important for maintaining vascular wall stability. The goal of this study is to generate a Myh11 dual reporter mouse line for de
Autor:
W. David Merryman, M. K. Sewell-Loftin, Jonathan H. Soslow, H. Scott Baldwin, Robert B. Hinton, Kate Violette, Leshana Saint-Jean, Xianghu Qu
Publikováno v:
Dev Biol
The mechanisms regulating endothelial cell response to hemodynamic forces required for heart valve development, especially valve remodeling, remain elusive. Tie1, an endothelial specific receptor tyrosine kinase, is up-regulated by oscillating shear
Autor:
Jian, Ruan, Lu, Zhang, Donghua, Hu, Xianghu, Qu, Fan, Yang, Fuxue, Chen, Xiangqin, He, Jian, Shen, Kunzhe, Dong, Megan, Sweet, Christina, Sanchez, Deqiang, Li, Weinian, Shou, Jiliang, Zhou, Chen-Leng, Cai
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 41(2)
The
Autor:
H. Scott Baldwin, Xianghu Qu
Publikováno v:
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension ISBN: 9789811511844
Ventricular chamber morphogenesis, characterized by trabeculae formation, is crucial for cardiac function and embryonic viability and depends on cellular interactions between the endocardium and myocardium. The ang1-Tie2 pathway is required for norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d701848d357abf029026a4f64892ad59
https://doi.org/10.1007/978-981-15-1185-1_52
https://doi.org/10.1007/978-981-15-1185-1_52
Autor:
Ralf H. Adams, Carolin Mogler, Soniya Savant, H. Scott Baldwin, Carleen Spegg, Hellmut G. Augustin, Mahak Singhal, Xianghu Qu, Lise Roth, Silvia La Porta, Benjamin Schieb
Publikováno v:
Journal of Clinical Investigation. 128:834-845
The endothelial tyrosine kinase receptor Tie1 remains poorly characterized, largely owing to its orphan receptor status. Global Tie1 inactivation causes late embryonic lethality, thereby reflecting its importance during development. Tie1 also plays p
Publikováno v:
JCI insight. 5
The ang1-tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) pathway is required for normal vascular development, but its molecular effectors are not well-defined during cardiac ontogeny. Here, we show that endocardial-specific att
Publikováno v:
Developmental Biology. 399(1):117-128
Tie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction of Tie1 levels in mouse embryos with a hypomorphic Tie1 allele resulted in abnormal lymphatic patterning and architecture, decreased lymphatic draining effic