Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Xianghang Shangguan"'
Autor:
Thomas E. Speltz, Zeyu Qiao, Colin S. Swenson, Xianghang Shangguan, John S. Coukos, Christopher W. Lee, Deborah M. Thomas, Jesse Santana, Sean W. Fanning, Geoffrey L. Greene, Raymond E. Moellering
Publikováno v:
Nature Biotechnology. 41:541-551
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817090da9ae4b01a5bbe054312722da7
https://doi.org/10.1038/s41587-022-01504-x
https://doi.org/10.1038/s41587-022-01504-x
Autor:
Thomas E, Speltz, Zeyu, Qiao, Colin S, Swenson, Xianghang, Shangguan, John S, Coukos, Christopher W, Lee, Deborah M, Thomas, Jesse, Santana, Sean W, Fanning, Geoffrey L, Greene, Raymond E, Moellering
Publikováno v:
Nature biotechnology.
Despite unequivocal roles in disease, transcription factors (TFs) remain largely untapped as pharmacologic targets due to the challenges in targeting protein-protein and protein-DNA interactions. Here we report a chemical strategy to generate modular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff907d855d7dee6430a301b1e57278a4
https://pubmed.ncbi.nlm.nih.gov/36302987
https://pubmed.ncbi.nlm.nih.gov/36302987
Autor:
Justin A. Donnelly, Jeffrey E. Montgomery, John S. Coukos, Sean W. Fanning, Thomas E. Speltz, Raymond E. Moellering, Xianghang Shangguan, Geoffrey L. Greene
Publikováno v:
J Am Chem Soc
Macrocyclization can improve bioactive peptide ligands through preorganization of molecular topology, leading to improvement of pharmacologic properties like binding affinity, cell permeability and metabolic stability. Here we demonstrate that Diels-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c77ef8345d49b120a6a29381f371ed
https://pubmed.ncbi.nlm.nih.gov/31523967
https://pubmed.ncbi.nlm.nih.gov/31523967
Publikováno v:
The Journal of Organic Chemistry. 80:7779-7784
An efficient and mild synthesis of 9H-fluorene derivatives through a Pd(0)-catalyzed cross-coupling reaction of 1,1-diboronates with 2,2'-dibromobiphenyls has been developed. This reaction features high yields, operational simplicity, and mild reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdd4cb933acb62d88677d17cf41c87f
https://doi.org/10.1021/acs.joc.5b01100
https://doi.org/10.1021/acs.joc.5b01100
Publikováno v:
Angewandte Chemie. 126:12115-12119
Palladium-catalyzed cross-coupling reactions of 1,1-diboronates with vinyl bromides and dibromoalkenes were found to afford 1,4-dienes and allenes, respectively. These reactions utilize the high reactivities of both 1,1-diboronates and allylboron int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4caf1201a4a48d5e3ac7f7c5f87dab28
https://doi.org/10.1002/ange.201407000
https://doi.org/10.1002/ange.201407000
Publikováno v:
ChemInform. 46
An efficient and mild synthesis of 9H-fluorene derivatives through a Pd(0)-catalyzed cross-coupling reaction of 1,1-diboronates with 2,2′-dibromobiphenyls has been developed. This reaction features high yields, operational simplicity, and mild reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43f254c4b698c008eef223dab171f5a5
https://doi.org/10.1002/chin.201550099
https://doi.org/10.1002/chin.201550099
Publikováno v:
ChemInform. 46
Palladium-catalyzed cross-coupling reactions of 1,1-diboronates with vinyl bromides and dibromoalkenes were found to afford 1,4-dienes and allenes, respectively. These reactions utilize the high reactivities of both 1,1-diboronates and allylboron int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a499489b3cbf54850fcd22698b840fd1
https://doi.org/10.1002/chin.201513088
https://doi.org/10.1002/chin.201513088
Publikováno v:
ChemInform. 45
A convenient method is developed to synthesize 1,1-diboronates from the corresponding N-tosylhydrazones which are easily obtained by reaction of the carbonyl compounds with tosylhydrazine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a63d94967f8be1735cf513b7bac46ea
https://doi.org/10.1002/chin.201426177
https://doi.org/10.1002/chin.201426177
Publikováno v:
Organic letters. 16(2)
A convenient method is developed to synthesize 1,1-diboronates from the corresponding N-tosylhydrazones. This method is also applicable to synthesize 1-silyl-1-boron compounds. Meanwhile, derivatization and consecutive Pd-catalyzed cross-coupling rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed0900fb2ba8f10144f9782bbe191f4
https://pubmed.ncbi.nlm.nih.gov/24350698
https://pubmed.ncbi.nlm.nih.gov/24350698
Publikováno v:
Journal of Organic Chemistry; 8/7/2015, Vol. 80 Issue 15, p7779-7784, 6p