Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Xiangfei Cheng"'
Autor:
Natalie A. O’Neill, MD, Tianshu Zhang, MD, PhD, Gheorghe Braileanu, PhD, Xiangfei Cheng, MD, PhD, Alena Hershfeld, MS, Wenji Sun, MD, PhD, Keith A. Reimann, PhD, Sia Dahi, MD, Natalia Kubicki, MD, Wessam Hassanein, MD, Christopher Laird, MD, Arielle Cimeno, MD, Agnes M. Azimzadeh, PhD, Richard N. Pierson, MD
Publikováno v:
Transplantation Direct, Vol 4, Iss 2, p e344 (2018)
Background. Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation and may represent an escape pathway for T-cell costimulation in the setting of CD40/CD154 costimulation blockade. Induction treatment exhibited no efficacy in a
Externí odkaz:
https://doaj.org/article/a36769921a3249b3820e3589d28a5ee9
Autor:
Donald G Harris, Prabhjot K Benipal, Xiangfei Cheng, Lars Burdorf, Agnes M Azimzadeh, Richard N Pierson
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123015 (2015)
Porcine xenografts are a promising source of scarce transplantable organs, but stimulate intense thrombosis of human blood despite targeted genetic and pharmacologic interventions. Current experimental models do not enable study of the blood/endothel
Externí odkaz:
https://doaj.org/article/287598f62c904fa08fe495cd4610801c
Autor:
Ryan Chaban, Zahra Habibabady, Wessam Hassanein, Margaret R. Connolly, Lars Burdorf, Emily Redding, Christopher Laird, Jolene Ranek, Gheorghe Braileanu, Selin Sendil, Xiangfei Cheng, Wenji Sun, Natalie A. O'Neill, Kasinath Kuravi, Sunghoon Hurh, David L. Ayares, Agnes M. Azimzadeh, Richard N. Pierson
Publikováno v:
Xenotransplantation. 29
Antibody-mediated rejection has long been known to be one of the major organ failure mechanisms in xenotransplantation. In addition to the porcine α1,3-galactose (α1,3Gal) epitope, N-Glycolylneuraminic acid (Neu5Gc), a sialic acid, has been identif
Autor:
Anthony Kronfli, E. Welty, Xiangfei Cheng, Richard N. Pierson, E. Rybak, Natalie A. O'Neill, Evelyn Sievert, Thomas S. Monahan, Emily Bergbower, Siamak Dahi, Agnes M. Azimzadeh, Gheorghe Braileanu, Chris Avon, Wenji Sun, Tianshu Zhang, Lars Burdorf, Donald G. Harris
Publikováno v:
Transplantation. 102:e90-e100
Selective CD28 inhibition is actively pursued as an alternative to B7 blockade using cytotoxic T lymphocyte antigen 4 Ig based on the hypothesis that the checkpoint immune regulators cytotoxic T lymphocyte antigen 4 and programmed death ligand 1 will
Autor:
Arielle Cimeno, Lindsay A. Hock, Tianshu Zhang, Natalia Kubicki, Agnes Azimzadeh, Anthony Kronfli, Natalie A. O'Neill, Christopher Laird, Siamak Dahi, Xiangfei Cheng, Evelyn Sievert, Wessam Hassanein, Wenji Sun, Gheorghe Braileanu, Richard N. Pierson, Alena Hershfeld
Publikováno v:
Transplantation. 101:2038-2047
Specific blockade of T cell costimulation pathway is a promising immunomodulatory approach being developed to replace our current clinical immunosuppression therapies. The goal of this study is to compare results associated with 3 monoclonal antibodi
Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys
Autor:
Richard N. Pierson, Xiangfei Cheng, Anthony Kronfli, C. Avon, Mitch Higuchi, Agnes M. Azimzadeh, Stuart L. Mitchell, Shahrooz S. Kelishadi, Alena Hershfeld, Natalie OʼNeill, E. Rybak, Guosheng Wu, T. Stoddard, E. Welty, Tianshu Zhang, Bao-Ngoc H. Nguyen, Lars Burdorf
Publikováno v:
Transplantation. 101:63-73
Anti-CD154 monotherapy is associated with antidonor allo-antibody (Ab) elaboration, cardiac allograft vasculopathy (CAV), and allograft failure in preclinical primate cell and organ transplant models. In the context of calcineurin inhibitors (CNI), t
Autor:
Richard N. Pierson, Margaret R. Connolly, Will Eyestone, Kaitlyn Petitpas, Carol Phelps, David Ayares, Agnes Azimzadeh, Xiangfei Cheng, Christopher Laird, Shannon Pratts, Benjamin Cerel, Zahra Abady, Lars Burdorf
Publikováno v:
Transplantation. 104:S637-S638
Autor:
Richard N. Pierson, David Ayares, C. Phelps, Kaitlyn Petitpas, Xiangfei Cheng, Christopher Laird, Margaret R. Connolly, Shannon Pratts, Benjamin Cerel, Agnes Azimzadeh, Will Eyestone, Zahra Alikhassy Habibabady, Lars Burdorf
Publikováno v:
The Journal of Heart and Lung Transplantation. 40:S51
Purpose Antibody-mediated xenograft rejection is inhibited by knock-out (KO) of porcine carbohydrates (CHO), including Galα1,3Gal. The β4Gal epitope was discovered using serum from xenograft-sensitized baboons. However, it remains controversial if
Autor:
Evelyn Sievert, Siamak Dahi, Xiangfei Cheng, David Ayares, Aakash Shah, Dawn Parsell, Tianshu Zhang, Lars Burdorf, Emily Redding, Evan A Schwartz, Richard N. Pierson, Donald G. Harris, Mercedes Thompson, Selin Sendil, Gheorghe Braileanu, Agnes Azimzadeh, Christopher Laird, F. Ali, C. Phelps
Publikováno v:
Xenotransplantation
BACKGROUND Elevated pulmonary vascular resistance (PVR), platelet adhesion, coagulation activation, and inflammation are prominent features of xenolung rejection. Here, we evaluate the role of thromboxane and histamine on PVR, and their contribution
Autor:
Agnes M. Azimzadeh, Xiangfei Cheng, Tianshu Zhang, Richard N. Pierson, Lars Burdorf, T. Stoddard, David Ayares, Muhammad Mohiuddin, Mohamed Ezzelarab, Chris Avon, Rolf N. Barth, Philip C. Corcoran, Avneesh K. Singh, Keith A. Horvath, Sean Kelishadi, Evelyn Sievert, David K. C. Cooper, Hayato Iwase
Publikováno v:
Xenotransplantation. 22:310-316
We describe the incidence of early graft failure (EGF, defined as loss of function from any cause within 3 days after transplant) in a large cohort of GalTKO pig organs transplanted into baboons in three centers, and the effect of additional expressi