Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Xiangfan Zhang"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Spermatogonial stem cells (SSCs) are the foundation of life-long spermatogenesis. While SSC research has advanced greatly over the past two decades, characterization of SSCs during postnatal development has not been well documented. Using th
Externí odkaz:
https://doaj.org/article/d0e77a58303b4c0083f0507e34c689dc
Autor:
Shreya Rajachandran, Xin Zhang, Qiqi Cao, Andre L. Caldeira-Brant, Xiangfan Zhang, Youngmin Song, Melanie Evans, Orhan Bukulmez, Edward J. Grow, Makoto Nagano, Kyle E. Orwig, Haiqi Chen
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112737- (2023)
Summary: Spermatogonial stem cells (SSCs) in the testis support the lifelong production of sperm. SSCs reside within specialized microenvironments called “niches,” which are essential for SSC self-renewal and differentiation. However, our underst
Externí odkaz:
https://doaj.org/article/f3375dcdc9284a48b949b1ec48933b23
Autor:
Xiangfan Zhang, Makoto Nagano
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3217 (2022)
Plasticizers give flexibility to a wide range of consumer and medical plastic products. Among them, phthalate esters are recognized as endocrine disruptors that target male reproductive functions. With this notion, past studies designed and produced
Externí odkaz:
https://doaj.org/article/30dedc3c327c4223b7658ddc00b02036
Autor:
Alexandre Boyer, Xiangfan Zhang, Adrien Levasseur, Nour Abou Nader, Guillaume St-Jean, Makoto C Nagano, Derek Boerboom
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa. Recently, a series of
Externí odkaz:
https://doaj.org/article/a5f945d92d5a42648ae0be699017d386
Autor:
Alexandre Boyer, Jonathan R Yeh, Xiangfan Zhang, Marilène Paquet, Aurore Gaudin, Makoto C Nagano, Derek Boerboom
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29764 (2012)
Constitutive activation of the WNT signaling effector CTNNB1 (β-catenin) in the Sertoli cells of the Ctnnb1(tm1Mmt/+);Amhr2(tm3(cre)Bhr/+) mouse model results in progressive germ cell loss and sterility. In this study, we sought to determine if this
Externí odkaz:
https://doaj.org/article/83ebb6dfb3e047559682ebba2a55abe5
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40002 (2012)
Proper regulation of spermatogonial stem cells (SSCs) is crucial for sustaining steady-state spermatogenesis. Previous work has identified several paracrine factors involved in this regulation, in particular, glial cell line-derived neurotrophic fact
Externí odkaz:
https://doaj.org/article/31fd436aaf1645d9a0ca91f796bb6132
Autor:
Xiangfan Zhang, Alexandre Boyer, Guillaume St-Jean, Adrien Levasseur, Makoto C. Nagano, Nour Abou Nader, Derek Boerboom
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa. Recently, a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a8d01f0586351e5ff7f17d00cbd61a
http://europepmc.org/articles/PMC8136708
http://europepmc.org/articles/PMC8136708
Autor:
Xiangfan Zhang, Derek Boerboom, Alexandre Boyer, Makoto C. Nagano, Nour Abou Nader, Adrien Levasseur
Publikováno v:
genesis. 57
Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is expressed in the nucleus of spermatogonia in mice, suggesting a potential role in spermatogenesis. Here, we report the generation of a conditional knockout mouse model (Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890719a3ae4f57ea82a2159f45f56920
https://doi.org/10.1002/dvg.23330
https://doi.org/10.1002/dvg.23330
Publikováno v:
PLoS ONE. Jun2012, Vol. 7 Issue 6, p1-9. 9p.
Autor:
Xiangfan Zhang, Keiko Shioda, Kurt J. Isselbacher, Norikatsu Miyoshi, Jente M. Stel, Junko Odajima, Makoto Nagano, Na Qu, Toshi Shioda, Konrad Hochedlinger, Shino Mitsunaga
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(34)
The genome-wide depletion of 5-methylcytosines (5meCs) caused by passive dilution through DNA synthesis without daughter strand methylation and active enzymatic processes resulting in replacement of 5meCs with unmethylated cytosines is a hallmark of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc172a5b57f8c2a51ecc59de55e3447
https://pubmed.ncbi.nlm.nih.gov/27621465
https://pubmed.ncbi.nlm.nih.gov/27621465