Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Xiangdang Shi"'
Autor:
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen syn
Externí odkaz:
https://doaj.org/article/9ce6582218524563975336a5db5daf95
Autor:
Cassandra Nocito, Cody Lubinsky, Michelle Hand, Sabeeya Khan, Tulsi Patel, Alecia Seliga, Malika Winfield, Viviana Zuluaga-Ramirez, Nicole Fernandes, Xiangdang Shi, Ellen M. Unterwald, Yuri Persidsky, Uma Sriram
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-organ damage. Neuropsychiatric lupus (NPSLE) is one of the most common manifestations of human SLE, often causing depression. Interferon-α (IFNα) is a central mediat
Externí odkaz:
https://doaj.org/article/f70f5d1d21e644b39358d516d10133f2
Autor:
Carolina Caban Rivera, Chau Do, Emma M. Fitzsimmons, Rachael E. Price, Xiangdang Shi, George M. Smith, Ellen M. Unterwald
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Neuroscience
The ventral hippocampus is a component of the neural circuitry involved with context-associated memory for reward and generation of appropriate behavioral responses to context. Glycogen synthase kinase 3 beta (GSK3β) has been linked to the maintenan
Publikováno v:
J Neurochem
Glycogen synthase kinase-3β (GSK3β) is a critical regulator of the balance between long-term depression and long-term potentiation which is essential for learning and memory. Our previous study demonstrated that GSK3β activity is highly induced du
Publikováno v:
J Pharmacol Exp Ther
Previous research has demonstrated that activity of glycogen synthase kinase-3 (GSK3) is necessary for the rewarding effects of cocaine. In the present study, a conditional GSK3β gene knockdown model was used to determine if GSK3β activity specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d59b5c6491f0e4dbb32447378ac83d
https://europepmc.org/articles/PMC6800444/
https://europepmc.org/articles/PMC6800444/
Autor:
Ellen M. Unterwald, Lauren J. Harper, Thomas J. Gould, Jonathan S. Miller, Xiangdang Shi, Rachel L. Poole
Publikováno v:
Psychopharmacology
Rational Memories return to a labile state following their retrieval and must undergo a process of reconsolidation to be maintained. Thus, disruption of cocaine reward memories by interference with reconsolidation may be therapeutically beneficial in
Publikováno v:
The Journal of Neuroscience. 31:834-842
Cocaine-mediated neuroadaptations in the prefrontal cortical-nucleus accumbens pathway underlie drug-seeking in animals with a cocaine self-administration (SA) history. Neuroplasticity in the cortico-accumbens pathway is regulated, in part, by the ex
Autor:
Xiangdang Shi, Jacqueline F. McGinty
Publikováno v:
Psychopharmacology. 214:653-663
Extracellular signal-regulated kinase (ERK), cAMP response element binding protein (CREB), and protein kinase B (PKB or Akt) in the striatum are differentially activated by acute and repeated amphetamine (AMPH) administration. However, the dopamine r
Autor:
Jacqueline F. McGinty, Xiangdang Shi
Publikováno v:
Journal of Neurochemistry. 103:706-713
Extracellular signal-regulated kinases, protein kinase B/Akt and cyclase response element-binding protein play important roles in drug-induced neuroadaptations. Acute psychostimulant exposure rapidly alters the phosphorylation of these proteins in th