Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Xiangao Sun"'
Publikováno v:
Nature Biotechnology. 26:1379-1382
RNA interference (RNAi) has become an indispensable technology for biomedical research and has demonstrated the potential to become a new class of therapeutic. Current RNAi technology in mammalian cells relies on short interfering RNA (siRNA) consist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8755f634464c15866c48c4df21b6bb
https://doi.org/10.1038/nbt.1512
https://doi.org/10.1038/nbt.1512
Autor:
Youzhi Li, A J Wang, Xiangao Sun, Jieti Sun, Bin Zhang, Keith Mikule, Zhiwei Jiang, Wei Li, Chiang J. Li
Publikováno v:
Cell Cycle. 5:2029-2035
Most efforts thus far have been devoted to develop apoptosis inducers for cancer treatment. However, apoptotic pathway deficiencies are a hallmark of cancer cells. We propose that one way to bypass defective apoptotic pathways in cancer cells is to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fb57df07b341183bf6f3ab34bd0cd3
https://doi.org/10.4161/cc.5.17.3312
https://doi.org/10.4161/cc.5.17.3312
Autor:
Ryouhei Izumi, Takashi Tani, Keiichi Muraoka, Kouichi Shimizu, Ken Ichi Yamamoto, Kouichi Miwa, Xiangao Sun
Publikováno v:
Transplantation Proceedings. 34:1335-1340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac951b0fe595ac276d53b7d0c111128
https://doi.org/10.1016/s0041-1345(02)02795-1
https://doi.org/10.1016/s0041-1345(02)02795-1
Autor:
Wei Li, Jun Oishi, Chiang J. Li, Jie Su, Janet Huang, Xiaoshu Dai, Erina Koga, Emily Brooks, Ewa Wybieralska, Xiangao Sun, Yuan Gao, Eric Hsu, Keyur Gada, Youzhi Li, Yuxin Wang
Publikováno v:
Cancer Research. 77:LB-069
RNAi (RNA interference) technology has the potential to target any genes causing disease, including conventionally “undruggable” targets in cancer. We previously discovered aiRNA (asymmetric interfering RNA), a next generation of gene-silencing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5931889a5306dfa62a6acbb39317e249
https://doi.org/10.1158/1538-7445.am2017-lb-069
https://doi.org/10.1158/1538-7445.am2017-lb-069
Abstract LB-142: Identification of STK33 as a cancer stemness kinase and regulator of Nanog function
Publikováno v:
Cancer Research. 77:LB-142
In recent years evidence has accumulated in support of the cancer stem cell (CSC) model in cancer chemotherapy resistance, highlighting the urgency and necessity of identifying CSC targets for developing novel cancer therapeutics. A number of studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6342ef99e10eef3875f0631f289dffb8
https://doi.org/10.1158/1538-7445.am2017-lb-142
https://doi.org/10.1158/1538-7445.am2017-lb-142
Publikováno v:
Journal of Biological Chemistry. 275:7470-7473
Protein kinase C (PKC) isoforms are phosphorylated on tyrosine in the response of cells to oxidative stress. The present studies demonstrate that treatment of cells with hydrogen peroxide (H(2)O(2)) induces binding of the PKCdelta isoform and the c-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9dc25b7aea73e5ea9a0f757e5f30cb
https://doi.org/10.1074/jbc.275.11.7470
https://doi.org/10.1074/jbc.275.11.7470
Autor:
Akiko Ikeda, Katsuji Yoshioka, Xiangao Sun, Kei Ichi Muraoka, Shigeki Miyamoto, Yong Kang Zhang, Hiroko Shimizu, Ken Ichi Yamamoto
Publikováno v:
Journal of Biological Chemistry. 274:34657-34662
The immunosuppressant FK506 activates NF-κB through IκBα degradation in nonlymphoid cells. In the present study, we analyzed mechanisms by which FK506 induces IκBα degradation. We found that FK506 induces the degradation of both IκBα and IκB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2077a99de5f93e01b7b2a37096bafb2
https://doi.org/10.1074/jbc.274.49.34657
https://doi.org/10.1074/jbc.274.49.34657
Autor:
Hisashi Shioya, Donald Kufe, Xiangao Sun, Yinyin Huang, Surender Kharbanda, Hua Lu, Zhi-Min Yuan, Ralph R. Weichselbaum, Jijie Gu, Takatoshi Ishiko
Publikováno v:
Nature. 399:814-817
The protein p73 is a structural and functional homologue of the p53 tumour-suppressor protein but, unlike p53, it is not induced in response to DNA damage1,2. The tyrosine kinase c-Abl is activated by certain DNA-damaging agents3 and contributes toth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a1d8ae10f6c60794f568c32f8ad311
https://doi.org/10.1038/21704
https://doi.org/10.1038/21704
Autor:
Tetsuo Hashimoto, Yong Kang Zhang, Ken Ichi Yamamoto, Kouichi Shimizu, Takashi Tani, Masao Yagi, Xiangao Sun, Itsuo Miyazaki, Kei Ichi Muraoka
Publikováno v:
Transplantation. 63:466-470
Interleukin (IL) 6 is one of major mediators of inflammation, and IL-6 gene activation during hypoxia/reoxygenation has been implicated in the pathogenesis of ischemia/reperfusion injury. However, molecular events involved in IL-6 gene expression dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5c5c09114c5ed1ada5fddde07d86df
https://doi.org/10.1097/00007890-199702150-00023
https://doi.org/10.1097/00007890-199702150-00023
Autor:
Xiangao Sun, Kei Ichi Muraoka, Ken Ichi Yamamoto, Koutaro Fujimoto, Masao Yagi, Kou Ichi Shimizu, Henry R Bose, Itsuo Miyazaki, Katsuji Yoshioka
Publikováno v:
Journal of Clinical Investigation. 97(11):2433-2439
金沢大学がん研究所がん分子細胞制御
FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-κB) critical for T cell activation. We
FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-κB) critical for T cell activation. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea045754543c4efae368d135b0a34259
http://hdl.handle.net/2297/7455
http://hdl.handle.net/2297/7455