cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells

Autor: Stefanie Fenske, Konstantin Hennis, René D. Rötzer, Verena F. Brox, Elvir Becirovic, Andreas Scharr, Christian Gruner, Tilman Ziegler, Verena Mehlfeld, Jaclyn Brennan, Igor R. Efimov, Audrys G. Pauža, Markus Moser, Carsten T. Wotjak, Christian Kupatt, Rasmus Gönner, Rai Zhang, Henggui Zhang, Xiangang Zong, Martin Biel, Christian Wahl-Schott

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)

The involvement of cAMP-dependent regulation of HCN4 in the chronotropic heart rate response is a matter of debate. Here the authors use a knockin mouse model expressing cAMP-insensitive HCN4 channels to discover an inhibitory nonfiring cell pool in

Externí odkaz: https://doaj.org/article/6c6af2794e4b4707a82af208feb04493

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel–associated retinopathy

Autor: Richard G. Weleber, Robert Lukowski, M. W. Seeliger, Christina Brennenstuhl, Anne E. Bausch, Xiangang Zong, Sascha Venturelli, John R. Heckenlively, Vithiyanjali Sothilingam, Stylianos Michalakis, Susanne C. Beck, Günther Rudolph, Naoyuki Tanimoto, Ulrich Kellner, Peggy Reuter, Anja K. Mayer, Ditta Zobor, Susanne Kohl, Bernd Wissinger, Gesa Astrid Hahn, Britta Baumann, Paul A. Sieving, Xi-Qin Ding, Nicole Weisschuh, Christian P. Hamel, Martin Biel, Robert K. Koenekoop, Peter Ruth, Peter Charbel Issa, Timm Krätzig, Gesine Huber, Elvir Becirovic, Markus Burkard, Katrin Junger

Publikováno v: The Journal of clinical investigation, vol 128, iss 12
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (12), pp.5663--5675. ⟨10.1172/JCI96098⟩

International audience; Mutations in CNGA3 and CNGB3, the genes encoding the subunits of the tetrameric cone photoreceptor cyclic nucleotide–gated ion channel, cause achromatopsia, a congenital retinal disorder characterized by loss of cone functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470e7ba4f9a01dd349b61665c4c93838
https://doi.org/10.1172/jci96098

Up-regulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 (HCN3) by Specific Interaction with K+ Channel Tetramerization Domain-containing Protein 3 (KCTD3)

Autor: Stylianos Michalakis, Xiaochun Cao-Ehlker, Xiangang Zong, Stefanie Fenske, Verena Hammelmann, Christian Gruner, Christian Wahl-Schott, Martin Biel

Publikováno v: Journal of Biological Chemistry. 288:7580-7589

Most ion channels consist of the principal ion-permeating core subunit(s) and accessory proteins that are assembled with the channel core. The biological functions of the latter proteins are diverse and include the regulation of the biophysical prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2708eb944e78d61072c06a11003bf8d
https://doi.org/10.1074/jbc.m112.434803

Restoration of Cone Vision in the CNGA3−/− Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function

Autor: Vidhyasankar Krishnamoorthy, Susanne Koch, Gesine Huber, E. Fahl, François Paquet-Durand, Xiangang Zong, Hildegard Büning, Susanne C. Beck, Lin Bai, Elvir Becirovic, Tim Gollisch, Martin Biel, Stylianos Michalakis, Regine Mühlfriedel, Naoyuki Tanimoto, Mathias W. Seeliger, M. Dominik Fischer

Publikováno v: Molecular Therapy. 18:2057-2063

Congenital absence of cone photoreceptor function is associated with strongly impaired daylight vision and loss of color discrimination in human achromatopsia. Here, we introduce viral gene replacement therapy as a potential treatment for this diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cbb008f61d7d12a83e6c5aa15d2c55
https://doi.org/10.1038/mt.2010.149

Direct Inhibition of Cardiac Hyperpolarization-Activated Cyclic Nucleotide–Gated Pacemaker Channels by Clonidine

Autor: Anne Knaus, Xiangang Zong, Nadine Beetz, Martin Biel, Martin J. Lohse, Roland Jahns, Lutz Hein

Publikováno v: Circulation. 115:872-880

Background— Inhibition of cardiac sympathetic tone represents an important strategy for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic heart failure. Activation of presynaptic α 2 -adrenoceptors is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f934c140e36ceacd2ea5bf18eb175f2
https://doi.org/10.1161/circulationaha.106.667675