Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Xiang-yang Ye"'
Autor:
Ying-Hui Yuan, Nian-Dong Mao, Ji-Long Duan, Hang Zhang, Carmen Garrido, Frédéric Lirussi, Yuan Gao, Tian Xie, Xiang-Yang Ye
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Adaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr kinases, is a specific key kinase regulating Thr156 phosphorylation at the μ2 subunit of the adapter complex-2 (AP-2) protein. Due to their important biological function
Externí odkaz:
https://doaj.org/article/3e6adc2500364272ade4b76cc24de15a
Autor:
Yuan Gao, Jilong Duan, Xiawen Dang, Yinghui Yuan, Yu Wang, Xingrui He, Renren Bai, Xiang-Yang Ye, Tian Xie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
β-Elemene is the major active ingredient of TCM anticancer drug elemene extracts. To further improve its antitumor activity and poor solubility, a polar HDACi pharmacophore was incorporated its scaffold. Systematic SAR studies led to the discovery o
Externí odkaz:
https://doaj.org/article/93747a8a7ef34340a0b60fac772009c2
Autor:
Renren Bai, Junlong Zhu, Ziqiang Bai, Qing Mao, Yingqian Zhang, Zi Hui, Xinyu Luo, Xiang-Yang Ye, Tian Xie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 379-385 (2022)
Elemene is a second-line broad-spectrum anti-tumour drug that has been used in China for more than two decades. However, its main anti-tumour ingredient, β-elemene, has disadvantages, including excessive lipophilicity and relatively weak anti-tumour
Externí odkaz:
https://doaj.org/article/c8330425afe34b52a41b54be2d86ebaf
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2403-2416 (2022)
A series of novel N-alkyl-N-hydroxyl carboximates derived from β-elemene were fortuitously discovered. Most of them showed more potent anti-proliferative activities than their lead compound β-elemene (1). Notably, compound 11i exhibited significant
Externí odkaz:
https://doaj.org/article/707aa9ee081e4afea07d1d5c814c1b9d
Autor:
Bo-Wen Sun, Peng-Peng Zhang, Zong-Hao Wang, Xia Yao, Meng-Lan He, Rui-Ting Bai, Hao Che, Jing Lin, Tian Xie, Zi Hui, Xiang-Yang Ye, Li-Wei Wang
Publikováno v:
Molecules, Vol 29, Iss 3, p 598 (2024)
Respiratory syncytial virus (RSV) is a significant viral pathogen that causes respiratory infections in infants, the elderly, and immunocompromised individuals. RSV-related illnesses impose a substantial economic burden worldwide annually. The molecu
Externí odkaz:
https://doaj.org/article/daf7da65a53340e6b47e63309fdef469
Autor:
Li Xu, Yuan Wang, Xingrui He, Yuan Gao, Frédéric Lirussi, Yi Zhou, Carmen Garrido, Hang Zhang, Tian Xie, Xiang-Yang Ye
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 7, Iss , Pp 100103- (2023)
Heat shock protein 110 (HSP110) is an emerging biological target for development of drug to treat colorectal cancer. In the present study, we designed and synthesized a series of novel small-molecule inhibitors of HSP110 based on previously reported
Externí odkaz:
https://doaj.org/article/58997d216e374dd38adac42e4da926ac
Autor:
Han Zou, Tingyue Wu, Yuan Wang, Yanhua Kang, Qingye Shan, Liqing Xu, Zheyi Jiang, Xiaohan Lin, Xiang-Yang Ye, Tian Xie, Hang Zhang
Publikováno v:
ACS Omega, Vol 6, Iss 42, Pp 28019-28030 (2021)
Externí odkaz:
https://doaj.org/article/bf9cb172d1354341bfd1497d0d7d8091
Autor:
Hang Zhang, Zheyi Jiang, Chuanbin Shen, Han Zou, Zhiping Zhang, Kaitao Wang, Renren Bai, Yanhua Kang, Xiang-Yang Ye, Tian Xie
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
5-Hydroxymethylfurfural (5-HMF) is a common reaction product during heat processing and the preparation of many types of foods and Traditional Chinese Medicine formulations. The aim of this study was to evaluate the protective effect of 5-HMF on endo
Externí odkaz:
https://doaj.org/article/677f623fc0164569b1050ccd91ae2635
Autor:
Li-Wei Wang, Songwei Jiang, Ying-Hui Yuan, Jilong Duan, Nian-Dong Mao, Zi Hui, Renren Bai, Tian Xie, Xiang-Yang Ye
Publikováno v:
Molecules, Vol 27, Iss 8, p 2491 (2022)
As one of the key phosphatidylinositol 3-kinase-related kinases (PIKKs) family members, ataxia telangiectasia and RAD3-related protein kinase (ATR) is crucial in maintaining mammalian cell genomic integrity in DNA damage response (DDR) and repair pat
Externí odkaz:
https://doaj.org/article/252851b55517414aa4ac1eb64c3fbf6a
Autor:
Maeva Wendremaire, Tatiana E. Lopez, Marina Barrichon, Hang Zhang, Tarik Hadi, Xiang-Yang Ye, Fabrice Neiers, Marc Bardou, Paul Sagot, Carmen Garrido, Frédéric Lirussi
Publikováno v:
Cells, Vol 11, Iss 6, p 954 (2022)
Maternal obesity is associated with a wide spectrum of labour disorders, including preterm birth. Leptin, a pro-inflammatory adipokine and a key factor of obesity, is suspected to play a major role in these disorders. OB-R, its receptor, is expressed
Externí odkaz:
https://doaj.org/article/d3a68d72671c4825990ef37d87f95059