Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Xiang-bo Wan"'
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
ABSTRACTDNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, m
Externí odkaz:
https://doaj.org/article/7751d5556522435ca788274cdf66af7c
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-10 (2023)
Abstract DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by exposure genome to ionizing radiation or genotoxic chemicals. DSBs are mainly repaired by homologous recombination (HR) and nonhomologous end joining (NHEJ).
Externí odkaz:
https://doaj.org/article/37087f77236f482fb697648277d8055a
Autor:
Jie Shi, Yi-Kan Cheng, Fang He, Jian Zheng, Yun-Long Wang, Xiang-Bo Wan, Hong-Cheng Lin, Xin-Juan Fan
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background Neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatment regimen for patients with locally advanced rectal cancer (LARC). This sphincter-saving treatment strategy may be accompanied by a series of
Externí odkaz:
https://doaj.org/article/7b4c858db413410ab17621da85345ea7
Autor:
Yun-Long Wang, Li-Li Feng, Jie Shi, Wan-Ying Chen, Shu-Ying Bie, Shao-Mei Bai, Guang-Dong Zeng, Rui-Zhi Wang, Jian Zheng, Xiang-Bo Wan, Xin-Juan Fan
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTNoncoding RNAs have been found to play important roles in DNA damage repair, whereas the participation of circRNA remains undisclosed. Here, we characterized ciRS-7, a circRNA containing over 70 putative miR-7-binding sites, as an enhancer of
Externí odkaz:
https://doaj.org/article/bee520bfbc00401088b402ce11f3625a
Autor:
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Yan Ma, Xin-Ke Yin, Li-Li Feng, Guang-Dong Zeng, Fang Wang, Wei-Xing Feng, Jian Zheng, Ying-Nai Wang, Bing Zeng, Quentin Liu, Mien-Chie Hung, Xiang-Bo Wan
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-13 (2022)
Abstract Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand breaks (DSB) repair, whereas its
Externí odkaz:
https://doaj.org/article/67b2f196f89c4d2e98e308070287c485
Autor:
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng, Shu-Ying Bie, Li Gong, Fang Wang, Ming-Biao Wei, Wei-Xing Feng, Xiao-Lin Pang, Cao-Litao Qin, Xin-Ke Yin, Ying-Nai Wang, Weihua Zhou, Daniel R. Wahl, Quentin Liu, Ming Chen, Mien-Chie Hung, Xiang-Bo Wan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The MRN complex is a critical sensor and processor of DNA double-strand breaks (DSBs). Here, the authors show that MRNIP forms liquid-like condensates to accelerate the MRN-mediated sensing and end resection of DSB, thereby promoting DSB repair.
Externí odkaz:
https://doaj.org/article/0d2d630dc0a747b8807be46604e76da1
Autor:
Jhih-Ying Chi, Yu-Wei Hsiao, Hai-Ling Liu, Xin-Juan Fan, Xiang-Bo Wan, Tsung-Lin Liu, Sheng-Jou Hung, Yi-Ting Chen, Hsin-Yin Liang, Ju-Ming Wang
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-16 (2021)
Abstract Cancer-associated fibroblasts (CAFs) play an essential role in supporting cancer progression. However, the details and consequent effects in response to the communication between CAFs and angiogenesis remain largely uninvestigated, especiall
Externí odkaz:
https://doaj.org/article/757da9e997c74013b8992407199a400b
Autor:
Qiao-xuan Wang, Rong Zhang, Wei-wei Xiao, Shu Zhang, Ming-biao Wei, Yong-heng Li, Hui Chang, Wei-hao Xie, Li-ren Li, Pei-rong Ding, Gong Chen, Zhi-fan Zeng, Wei-hu Wang, Xiang-bo Wan, Yuan-hong Gao
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-8 (2021)
Abstract Background The watch-and-wait strategy offers a non-invasive therapeutic alternative for rectal cancer patients who have achieved a clinical complete response (cCR) after chemoradiotherapy. This study aimed to investigate the long-term clini
Externí odkaz:
https://doaj.org/article/babda910c4bb48308aaf8a3cb193ba1f
Autor:
Huai‐Qiang Ju, Qi Zhao, Feng Wang, Ping Lan, Zixian Wang, Zhi‐Xiang Zuo, Qi‐Nian Wu, Xin‐Juan Fan, Hai‐Yu Mo, Li Chen, Ting Li, Chao Ren, Xiang‐Bo Wan, Gong Chen, Yu‐Hong Li, Wei‐Hua Jia, Rui‐Hua Xu
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-13 (2019)
Abstract Accurate risk stratification for patients with stage II/III colon cancer is pivotal for postoperative treatment decisions. Here, we aimed to identify and validate a circRNA‐based signature that could improve postoperative prognostic strati
Externí odkaz:
https://doaj.org/article/94e8fd3a10b94556b180eefd64ab1aa9
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: The addition of intensive preoperative chemotherapy and using of a longer waiting period between neoadjuvant radiotherapy and total mesorectal excision (TME) surgery lengthen the time interval from the initiation of neoadjuvant treatment
Externí odkaz:
https://doaj.org/article/0ef522fa10a14ccc85b06746b78a024b