Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Xiang-Xi Xu"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Cancer cells evolve to be refractory to the intrinsic programmed cell death mechanisms, which ensure cellular tissue homeostasis in physiological conditions. Chemotherapy using cytotoxic drugs seeks to eliminate cancer cells but spare non-cancerous h
Externí odkaz:
https://doaj.org/article/cbb7841037eb48aa87decfe110f56a6a
Publikováno v:
Acta Materia Medica, Vol 1, Iss 4, Pp 552-562 (2022)
Osteosarcoma, a primary malignant tumor of the skeleton, has a morbidity of 2.5 per 1 million people. The epiphysis of extremities is typically affected. Osteosarcoma has a high likelihood of early metastasis, rapid progression, and poor prognosis. T
Externí odkaz:
https://doaj.org/article/9e4b1f7a2fbc498dbe4d05c47052fd58
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Paclitaxel (Taxol) is a microtubule-stabilizing drug used to treat several solid tumors, including ovarian, breast, non-small cell lung, and pancreatic cancers. The current treatment of ovarian cancer is chemotherapy using paclita
Externí odkaz:
https://doaj.org/article/b202680307cc476ab5deb55ef8f18a59
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Taxanes and CDK4/6 inhibitors (CDK4/6i) are two families of successful anti-mitotic drugs used in the treatment of solid tumors. Paclitaxel, representing taxane compounds, has been used either alone or in combination with other agents (commonly carbo
Externí odkaz:
https://doaj.org/article/8368702b2245426eb661270bc34a9171
Publikováno v:
Biomarker Research, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Background In most women with ovarian cancer, the diagnosis occurs after dissemination of tumor cells beyond ovaries. Several molecular perturbations occur ahead of tumor initiation including loss of lamin A/C. Our hypothesis was that the lo
Externí odkaz:
https://doaj.org/article/c8363ce9a6174b14b090a91424f6ba24
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 5, Pp 809-817 (2016)
High serum cholesterol (hypercholesterolemia) strongly associates with cardiovascular diseases as the atherogenic LDLs promote atheroma development in arteries (atherosclerosis). LDL clearance from the circulation by LDL receptor (LDLR)-mediated endo
Externí odkaz:
https://doaj.org/article/4fc78c7e79af4914a10d37680a524b06
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer. In high-grade serous ovarian cancer, the only common gene aberrati
Externí odkaz:
https://doaj.org/article/6e7734f552f44d128b8e90126a58dc3a
Autor:
Kathy Qi Cai, Ying Wang, Elizabeth R. Smith, Jennifer L. Smedberg, Dong-Hua Yang, Wan-Lin Yang, Xiang-Xi Xu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 1, Pp 89-100 (2015)
White spotting variant (Wv) mice are spontaneous mutants attributed to a point mutation in the c-Kit gene, which reduces the tyrosine kinase activity to around 1% and affects the development of melanocytes, mast cells, and germ cells. Homozygous muta
Externí odkaz:
https://doaj.org/article/d72b8ad0806a4c0b8311c1bd70b9f2f1
Publikováno v:
Biology Open, Vol 3, Iss 2, Pp 121-128 (2014)
Summary The primitive endoderm epithelial structure in mouse blastocysts forms following cell differentiation and subsequent sorting, and this two-step process can be reproduced in vitro using an embryoid body model. We found that in the chimeric emb
Externí odkaz:
https://doaj.org/article/75485f7cff884fc8bc6c894219c07c3c
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110737 (2014)
Disabled-2 (Dab2) is a widely expressed endocytic adaptor that was first isolated as a 96 KDa phospho-protein, p96, involved in MAPK signal transduction. Dab2 expression is lost in several cancer types including breast cancer, and Dab2 is thought to
Externí odkaz:
https://doaj.org/article/8c5a8bb1c21e4eaeaa8b2f2fae428f43