Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Xiang-Qun Gong"'
Publikováno v:
Canadian Journal of Physiology & Pharmacology. May2007, Vol. 85 Issue 5, p546-555. 9p. 1 Diagram, 6 Graphs.
Autor:
Xiang-Qun Gong1, Frandsen, Anne2, Wei-Yang Lu3, Yudi Wan3, Zabek, Rebecca L.1, Pickering, Darryl S.2, Donglin Bai1 donglin.bai@fmd.uwo.ca
Publikováno v:
British Journal of Pharmacology. Jun2005, Vol. 145 Issue 4, p449-459. 11p.
Autor:
Donglin Bai, Michael K. G. Stewart, Glenn I. Fishman, Kevin J. Barr, Dale W. Laird, Xiang-Qun Gong
Publikováno v:
Biochemical Journal
Genetically modified mice mimicking ODDD (oculodentodigital dysplasia), a disease characterized by reduced Cx43 (connexin 43)-mediated gap junctional intercellular communication, represent an in vivo model to assess the role of Cx43 in mammary gland
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83c3c1d8764e99298a0adf59e65a983
https://doi.org/10.1042/bj20121070
https://doi.org/10.1042/bj20121070
Autor:
Qing Shao, Kathryn J. Swoboda, Xiang qun Gong, Donglin Bai, Dale W. Laird, Jared M. Churko, Jacinda B. Sampson
Publikováno v:
Human Mutation. 32:456-466
Oculodentodigital dysplasia (ODDD) is primarily an autosomal dominant human disease caused by any one of over 60 mutations in the GJA1 gene encoding the gap junction protein Cx43. In the present study, wound healing was investigated in a G60S ODDD mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc5ccc39145fc8eea872c35f093f758
https://doi.org/10.1002/humu.21472
https://doi.org/10.1002/humu.21472
Autor:
Donglin Bai, Jared M. Churko, Dale W. Laird, Qing Shao, Janet L. Manias, Xiang qun Gong, Isabelle Plante
Publikováno v:
Cardiovascular Research. 80:385-395
Aims More than 40 mutations in the GJA1 gene encoding connexin43 (Cx43) have been linked to oculodentodigital dysplasia (ODDD), a pleiotropic, autosomal dominant disorder. We hypothesized that even with a significant reduction in the levels of Cx43 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb0f745f315391b47fc1c24707afb77
https://doi.org/10.1093/cvr/cvn203
https://doi.org/10.1093/cvr/cvn203
Publikováno v:
Journal of Biological Chemistry. 281:31801-31811
A frameshift mutation generated from a dinucleotide deletion (780-781del) in the GJA1 gene encoding Cx43 results in a frameshift yielding 46 aberrant amino acids after residue 259 and a shortened protein of 305 residues compared with the 382 in wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849e20b8902d7c80e334ccd0b4b2b679
https://doi.org/10.1074/jbc.m605961200
https://doi.org/10.1074/jbc.m605961200
Autor:
Andrew D. Krahn, Lynne Danis, Alexandre F.R. Stewart, Xiaoqin Liu, Douglas L. Jones, Gerard M. Guiraudon, Donglin Bai, George Klein, Raymond Yee, Michael H. Gollob, John P. Veinot, Anthony S.L. Tang, Allan C. Skanes, Frédérique Tesson, Lisa Ebihara, Xiang-Qun Gong, Qing Shao
Publikováno v:
New England Journal of Medicine. 354:2677-2688
BACKGROUND Atrial fibrillation is the most common type of cardiac arrhythmia and a leading cause of cardiovascular morbidity, particularly stroke. The cardiac gap-junction protein connexin 40 is expressed selectively in atrial myocytes and mediates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f029fd5f938a0904f74267df7916ae1
https://doi.org/10.1056/nejmoa052800
https://doi.org/10.1056/nejmoa052800
Autor:
Wei-Yang Lu, Yudi Wan, Anne Frandsen, Rebecca L. ZabekR.L. Zabek, Xiang-Qun Gong, Donglin Bai, Darryl S. Pickering
Publikováno v:
British Journal of Pharmacology. 145:449-459
1 The amino acid, D-aspartate, exists in the mammalian brain and is an agonist at the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors. Here, for the first time, we studied the actions of D-aspartate on alpha-amino-3-hydroxyl-5-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::534914622b03e7e8cbf2fd64c5dd757a
https://doi.org/10.1038/sj.bjp.0706199
https://doi.org/10.1038/sj.bjp.0706199
Autor:
Elizabeth McLachlan, Donglin Bai, Suzanne M. Bernier, Janet L. Manias, Crystal S. Lounsbury, Qing Shao, Xiang-Qun Gong, Dale W. Laird
Publikováno v:
Cell Communication & Adhesion. 12:279-292
Oculodentodigital dysplasia (ODDD) is associated with at least 28 connexin43 (Cx43) mutations. We characterized four of these mutants; Q49K, L90V, R202H, and V216L. Populations of these GFP-tagged mutants were transported to the cell surface in Cx43-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b750e78507edf6499078cca3888b3d45
https://doi.org/10.1080/15419060500514143
https://doi.org/10.1080/15419060500514143
Autor:
Xiang Qun Gong, Bruce J. Nicholson
Publikováno v:
Cell Communication & Adhesion. 8:187-192
Gap junction channels are traditionally viewed as large, nonspecific pores connecting cells. Recently the diversity in the connexin family has drawn more attention to their permeability characteristics. Several studies have shown that both size and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e342073a0b12133db1f3ab8a36b9443
https://doi.org/10.3109/15419060109080721
https://doi.org/10.3109/15419060109080721