Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Xiang-Peng Kong"'
Autor:
Sudershana Nair, Yixiang Jiang, Isabella S. Marchal, Elizabeth Chernobelsky, Huai-Wei Huang, Sarah Suh, Ruimin Pan, Xiang-Peng Kong, Hyung Don Ryoo, Einar M. Sigurdsson
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-14 (2024)
Abstract Tauopathies are a group of neurodegenerative diseases characterized by the presence of tau inclusions. We have developed over fifty anti-tau single-domain antibodies (sdAbs) derived from phage display libraries of a llama immunized with reco
Externí odkaz:
https://doaj.org/article/3d4f4ad8cced47af957582702dc480ca
Autor:
Yixiang Jiang, Yan Lin, Amber M. Tetlow, Ruimin Pan, Changyi Ji, Xiang-Peng Kong, Erin E. Congdon, Einar M. Sigurdsson
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-24 (2024)
Abstract Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for synucleinopathies, a
Externí odkaz:
https://doaj.org/article/a84e6645814e4c4b8b53a044a5b7e94a
Autor:
Shixia Wang, Kun-Wei Chan, Danlan Wei, Xiuwen Ma, Shuying Liu, Guangnan Hu, Saeyoung Park, Ruimin Pan, Ying Gu, Alexandra F. Nazzari, Adam S. Olia, Kai Xu, Bob C. Lin, Mark K. Louder, Krisha McKee, Nicole A. Doria-Rose, David Montefiori, Michael S. Seaman, Tongqing Zhou, Peter D. Kwong, James Arthos, Xiang-Peng Kong, Shan Lu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The vaccine elicitation of HIV tier-2-neutralization antibodies has been a challenge. Here, we report the isolation and characterization of a CD4-binding site (CD4bs) specific monoclonal antibody, HmAb64, from a human volunteer immunized wit
Externí odkaz:
https://doaj.org/article/d4067003b45c4b2ab1dab731384dc0c2
Autor:
Chitra Upadhyay, Priyanka Rao, Mohammad Amin Behzadi, Roya Feyznezhad, Gregory S. Lambert, Rajnish Kumar, Madhu Kumar, Weiming Yang, Xunqing Jiang, Christina C. Luo, Arthur Nadas, James Arthos, Xiang-Peng Kong, Hui Zhang, Catarina E. Hioe, J. Andrew Duty
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHIV-1 envelope (Env) is the key target for antibodies (Abs) against the virus and thus an important HIV-1 vaccine component. Env is synthesized from a gp160 precursor with a signal peptide (SP) at its N-terminus. This study investigated t
Externí odkaz:
https://doaj.org/article/0dc36d13c96d45f2af750673eba6e9f0
Autor:
Daniel W. Heindel, Dania M. Figueroa Acosta, Marisa Goff, Clauvis Kunkeng Yengo, Muzafar Jan, Xiaomei Liu, Xiao-Hong Wang, Mariya I. Petrova, Mo Zhang, Manish Sagar, Phillip Barnette, Shilpi Pandey, Ann J. Hessell, Kun-Wei Chan, Xiang-Peng Kong, Benjamin K. Chen, Lara K. Mahal, Barbara A. Bensing, Catarina E. Hioe
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110390- (2024)
Summary: Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind bacteria or bacterial products to impact infectivity and transmiss
Externí odkaz:
https://doaj.org/article/e5305c3f335e45a9a5819c9e033eed91
Autor:
Catarina E. Hioe, Xiaomei Liu, Andrew N. Banin, Daniel W. Heindel, Je´romine Klingler, Priyanka G. Rao, Christina C. Luo, Xunqing Jiang, Shilpi Pandey, Tracy Ordonez, Philip Barnette, Maxim Totrov, Jiang Zhu, Arthur Na´das, Susan Zolla-Pazner, Chitra Upadhyay, Xiaoying Shen, Xiang-Peng Kong, Ann J. Hessell
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/e87e857a47b44752a1a5a805fcf33bae
Autor:
Catarina E. Hioe, Xiaomei Liu, Andrew N. Banin, Daniel W. Heindel, Jéromine Klingler, Priyanka G. Rao, Christina C. Luo, Xunqing Jiang, Shilpi Pandey, Tracy Ordonez, Philip Barnette, Maxim Totrov, Jiang Zhu, Arthur Nádas, Susan Zolla-Pazner, Chitra Upadhyay, Xiaoying Shen, Xiang-Peng Kong, Ann J. Hessell
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionNeutralizing antibodies (Abs) are one of the immune components required to protect against viral infections. However, developing vaccines capable of eliciting neutralizing Abs effective against a broad array of HIV-1 isolates has been an
Externí odkaz:
https://doaj.org/article/bd3b1a8708a244ec9f1494a4fcb1f13f
Publikováno v:
Orthopaedic Surgery, Vol 14, Iss 8, Pp 1912-1917 (2022)
Background Robotic‐assisted technology may be useful in hip revision cases with acetabular defects. However, data on the use of robotic‐assisted technology for such complex diseases is lacking. Case Presentation This case study described the adop
Externí odkaz:
https://doaj.org/article/478e1cf2ff5042e0ad9894369c5e0cbe
Autor:
Svenja Weiss, Vincenza Itri, Ruimin Pan, Xunqing Jiang, Christina C. Luo, Lynn Morris, Delphine C. Malherbe, Philip Barnette, Jeff Alexander, Xiang-Peng Kong, Nancy L. Haigwood, Ann J. Hessell, Ralf Duerr, Susan Zolla-Pazner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors show that an HIV vaccine in non-human primates that focuses antibodies on the V1V2 region of gp120 is superior to infection or immunization with whole envelope vaccines for inducing V1V2 antibodies with anti-viral functions that corr
Externí odkaz:
https://doaj.org/article/a623118e7a31438db01163d784cdf0fa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Mapping of the HIV Env surface epitopes targeted by broadly neutralizing antibodies (bNAbs) is of great interest for HIV-1 vaccine design. Here, the authors present the 3.2 Å cryo-EM structure of the bNAb M4008_N1 in complex with BG505 DS-SOSIP, an
Externí odkaz:
https://doaj.org/article/bb01949e422e42d6906fec7ea24e7540