Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Xiang-Ming Zha"'
Autor:
David Shore, Nosakhere Griggs, Vincent Graffeo, A. R. M. Ruhul Amin, Xiang-ming Zha, Yan Xu, Jeremy P. McAleer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Head and neck cancer is the sixth most common malignancy, and there is an urgent need to identify physiological processes contributing to tumorigenesis. Extracellular acidification caused by aerobic glycolysis within tumor microenvironments
Externí odkaz:
https://doaj.org/article/b2d9b17ab1964f608106a3eb67715760
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-5 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/e78eff239fd347c19ce8bee52fa5e578
Publikováno v:
Brain Hemorrhages, Vol 1, Iss 4, Pp 185-191 (2020)
Hemorrhagic transformation (HT) following ischemia is one complication which worsens stroke outcome. During and after ischemia–reperfusion, persistent reduction of brain pH occurs. In a recent study, we found that GPR68 functions as a neuronal prot
Externí odkaz:
https://doaj.org/article/fd6a9e4f6e05450d829df5f60043ad10
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-5 (2020)
Abstract Increased neural activities reduced pH at the synaptic cleft and interstitial spaces. Recent studies have shown that protons function as a neurotransmitter. However, it remains unclear whether protons signal through a metabotropic receptor t
Externí odkaz:
https://doaj.org/article/77392a0017114b05969e1e4a303622e1
Autor:
Guokun Zhou, Xiang-ming Zha
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Persistent acidosis occurs in ischemia and multiple neurological diseases. In previous studies, acidic stimulation leads to rapid increase in intracellular calcium in neurons. However, it remains largely unclear how a prolonged acidosis alters neuron
Externí odkaz:
https://doaj.org/article/f12fcd1fd9194486ba541541f3b47d20
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1264 (2020)
Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions. Here, we found that
Externí odkaz:
https://doaj.org/article/3929cbe09256408f8c61548d9b2759ae
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26909 (2011)
Acid-sensing ion channel-1a (ASIC1a), the primary proton receptor in the brain, contributes to multiple diseases including stroke, epilepsy and multiple sclerosis. Thus, a better understanding of its biogenesis will provide important insights into th
Externí odkaz:
https://doaj.org/article/01348445c6ff49c997ce0d34820be04c
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:1349-1363
Extracellular proton concentration is at 40 nM when pH is 7.4. In disease conditions such as brain ischemia, proton concentration can reach µM range. To respond to this increase in extracellular proton concentration, the mammalian brain expresses at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d7a9fc799e53516f0538e79d989ec8
https://doi.org/10.1177/0271678x221089074
https://doi.org/10.1177/0271678x221089074
Publikováno v:
Brain Hemorrhages, Vol 1, Iss 4, Pp 185-191 (2020)
Brain Hemorrhages
Brain Hemorrhages
Hemorrhagic transformation (HT) following ischemia is one complication which worsens stroke outcome. During and after ischemia-reperfusion, persistent reduction of brain pH occurs. In a recent study, we found that GPR68 functions as a neuronal proton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbca8447f4d66e29e42f69747a18120
https://doi.org/10.1016/j.hest.2020.10.001
https://doi.org/10.1016/j.hest.2020.10.001
Autor:
mingdi he, Tao Wang, Yan Xu, Xiang-ming Zha, Roger P. Simon, Yuanyuan Xu, Guokun Zhou, Zhi-Gang Xiong, w.g. Rusyniak, Yonghua Ji
Publikováno v:
Stroke. 52
Introduction: Acidosis is one prevalent phenomenon in ischemic stroke. The literature has shown that protons directly gate acid-sensing ion channels (ASICs) and proton-activated chloride channel, both lead to neuronal injury However, it is unclear wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4093fbef8f4084180e143f1d7ba468fb
https://doi.org/10.1161/str.52.suppl_1.p747
https://doi.org/10.1161/str.52.suppl_1.p747