Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Xiang-Lei Yang"'
Autor:
Taisuke Kanaji, Xiang-Lei Yang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102297- (2024)
Externí odkaz:
https://doaj.org/article/0abf47a10c4f42e9b8c5dcd24377aff8
Autor:
Elena R. Rhymes, Rebecca L. Simkin, Ji Qu, David Villarroel-Campos, Sunaina Surana, Yao Tong, Ryan Shapiro, Robert W. Burgess, Xiang-Lei Yang, Giampietro Schiavo, James N. Sleigh
Publikováno v:
Neurobiology of Disease, Vol 195, Iss , Pp 106501- (2024)
Charcot-Marie-Tooth disease (CMT) is a genetic peripheral neuropathy caused by mutations in many functionally diverse genes. The aminoacyl-tRNA synthetase (ARS) enzymes, which transfer amino acids to partner tRNAs for protein synthesis, represent the
Externí odkaz:
https://doaj.org/article/6a2c5beddc18443097b6a65f58d65c80
Autor:
Biljana Ermanoska, Bob Asselbergh, Laura Morant, Maria-Luise Petrovic-Erfurth, Seyyedmohsen Hosseinibarkooie, Ricardo Leitão-Gonçalves, Leonardo Almeida-Souza, Sven Bervoets, Litao Sun, LaTasha Lee, Derek Atkinson, Akram Khanghahi, Ivaylo Tournev, Patrick Callaerts, Patrik Verstreken, Xiang-Lei Yang, Brunhilde Wirth, Avital A. Rodal, Vincent Timmerman, Bruce L. Goode, Tanja A. Godenschwege, Albena Jordanova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Mutations in tRNA ligases, essential components of the translational machinery, are associated with Charcot-Marie-Tooth peripheral neuropathy, but the mechanistic details are not known. The authors report that the tyrosyl-tRNA synthetase is an evolut
Externí odkaz:
https://doaj.org/article/10366423a6464375b1b796d7bfb9bd6f
Autor:
Julia A. Jones, Na Wei, Haissi Cui, Yi Shi, Guangsen Fu, Navin Rauniyar, Ryan Shapiro, Yosuke Morodomi, Nadine Berenst, Calin Dan Dumitru, Sachiko Kanaji, John R. Yates, III, Taisuke Kanaji, Xiang-Lei Yang
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112632- (2023)
Summary: Various stress conditions are signaled through phosphorylation of translation initiation factor eukaryotic initiation factor 2α (eIF2α) to inhibit global translation while selectively activating transcription factor ATF4 to aid cell surviv
Externí odkaz:
https://doaj.org/article/a0eab927d61c4462b44a1c35a518cd79
Autor:
Noemi Gioelli, Lisa J. Neilson, Na Wei, Giulia Villari, Wenqian Chen, Bernhard Kuhle, Manuel Ehling, Federica Maione, Sander Willox, Serena Brundu, Daniele Avanzato, Grigorios Koulouras, Massimiliano Mazzone, Enrico Giraudo, Xiang-Lei Yang, Donatella Valdembri, Sara Zanivan, Guido Serini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Functional vascular tree formation is a key step in many contexts, such as cancer, and Neuropilin1 (NRP1) has been associated with adhesion receptor endocytic turnover. Here, authors show NRP1 and its mini-WARS ligand play a role in reducing endothel
Externí odkaz:
https://doaj.org/article/2f35d1709b354aba9e4278bad5764f45
Autor:
James N. Sleigh, David Villarroel-Campos, Sunaina Surana, Tahmina Wickenden, Yao Tong, Rebecca L. Simkin, Jose Norberto S. Vargas, Elena R. Rhymes, Andrew P. Tosolini, Steven J. West, Qian Zhang, Xiang-Lei Yang, Giampietro Schiavo
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Gain-of-function mutations in the housekeeping gene GARS1, which lead to the expression of toxic versions of glycyl-tRNA synthetase (GlyRS), cause the selective motor and sensory pathology characterizing Charcot-Marie-Tooth disease (CMT). Aberrant in
Externí odkaz:
https://doaj.org/article/b67b689534054283ad3f0ed434509f29
Autor:
Jin Zhao, Hangming Bai, Xiaoyu Li, Jie Yan, Gengyi Zou, Longlong Wang, Xiru Li, Ze Liu, Rong Xiang, Xiang-Lei Yang, Yi Shi
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract Abnormally enhanced de novo lipid biosynthesis has been increasingly realized to play crucial roles in the initiation and progression of varieties of cancers including breast cancer. However, the mechanisms underlying the dysregulation of li
Externí odkaz:
https://doaj.org/article/f0ae40b6a7704a3ab372347fe73303bc
Autor:
Bingyi Chen, Siting Luo, Songxuan Zhang, Yingchen Ju, Qiong Gu, Jun Xu, Xiang-Lei Yang, Huihao Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Reveromycin A (RM-A) selectively inhibits eukaryotic cytoplasmic isoleucyltRNA synthetase (IleRS). Herein, the authors show that RM-A molecule occupies the tRNAIle binding site of Saccharomyces cerevisiae IleRS, and that RM-A cooperates with isoleuci
Externí odkaz:
https://doaj.org/article/aa106fd7577240a4b8e1ff9e7d96b4fa
Autor:
Eric Won, Yosuke Morodomi, Sachiko Kanaji, Ryan Shapiro, My‐Nuong Vo, Jennifer N. Orje, Courtney D. Thornburg, Xiang‐Lei Yang, Zaverio M. Ruggeri, Paul Schimmel, Taisuke Kanaji
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 7, Pp 1167-1177 (2020)
Abstract Background Tyrosyl‐tRNA synthetase (YRS) belongs to the family of enzymes that catalyzes the tRNA aminoacylation reaction for protein synthesis, and it has been recently shown to exert noncanonical functions. Although database results indi
Externí odkaz:
https://doaj.org/article/e4c71f223dd0404b8b8a219a41077875
Autor:
Sven Bervoets, Na Wei, Maria-Luise Erfurth, Shazie Yusein-Myashkova, Biljana Ermanoska, Ligia Mateiu, Bob Asselbergh, David Blocquel, Priyanka Kakad, Tyrone Penserga, Florian P Thomas, Velina Guergueltcheva, Ivailo Tournev, Tanja Godenschwege, Albena Jordanova, Xiang-Lei Yang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Tyrosyl-tRNA synthetase (TyrRS) is a translation factor and predominantly cytoplasmic, but can also be found in the nucleus. Here authors show using a fly model of Charcot-Marie-Tooth (CMT) disease that nuclear localization of mutant TyrRS contribute
Externí odkaz:
https://doaj.org/article/21bb42563b3e4403b71172f684a5c1f1