Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Xiang-Guo Hu"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract N-Glycosylated heterocycles play important roles in biological systems and drug development. The synthesis of these compounds heavily relies on ionic N-glycosylation, which is usually constrained by factors such as labile glycosyl donors, pr
Externí odkaz:
https://doaj.org/article/0d1e767801134613b20cf25f16ba1a34
Autor:
Raju Cheerlavancha, Ahmed Ahmed, Yun Cheuk Leung, Aggie Lawer, Qing-Quan Liu, Marina Cagnes, Hee-Chan Jang, Xiang-Guo Hu, Luke Hunter
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2316-2325 (2017)
Backbone-extended amino acids have a variety of potential applications in peptide and protein science, particularly if the geometry of the amino acid is controllable. Here we describe the synthesis of δ-amino acids that contain three vicinal C–F b
Externí odkaz:
https://doaj.org/article/8f6f4ba5619d414e9591e238346ecde5
Autor:
Xiang-Guo Hu, Luke Hunter
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 2696-2708 (2013)
The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties. These changes can be rationally exploited for the benefit of diverse fields such as medicinal c
Externí odkaz:
https://doaj.org/article/8112659e8aa44570bd95403acc9a408f
Autor:
Amber L. Thompson, Agnieszka Michalik, Robert J. Nash, Francis X. Wilson, Renate van Well, Peter Johnson, George W. J. Fleet, Chu-Yi Yu, Xiang-Guo Hu, Richard I. Cooper, David J. Watkin
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 11, Pp o2904-o2905 (2009)
X-ray crystallographic analysis of the title hydrobromide salt, C10H20N+·Br−, of (1R,2S,3R,5R,8aR)-3-hydroxymethyl-5-methyloctahydroindolizine-1,2-diol defines the absolute and relative stereochemistry at the five chiral centres in steviamine, a n
Externí odkaz:
https://doaj.org/article/5291fcab05ff425dbeb8474867a68d7c
Publikováno v:
Organic Letters; 7/26/2024, Vol. 26 Issue 29, p6225-6229, 5p
Publikováno v:
Organic Letters. 24:9130-9134
We have developed a dual copper/photoredox-catalyzed approach for the construction of the P(O)-N bond from commercially available aromatic amines and P(O)-H compounds. This metallaphotoredox method avoids toxic or corrosive reagents and does not requ
Publikováno v:
Green Chemistry. 24:8280-8291
A metal-free, photo-mediated method for the synthesis of C2-phosphorylated carbohydrates has been developed, whose reaction mechanism consists of the reduction of a glycosyl radical to a glycosyl anion.
Publikováno v:
The Journal of Organic Chemistry. 87:1272-1284
Inspired by Roush's pioneering work on rare sugars, we have developed a scalable, stereoselective, de novo synthesis of orthogonally protected C2-fluoro digitoxose and cymarose, utilizing Sharpless kinetic resolution and organocatalytic fluorination
Publikováno v:
Organic Letters. 23:8899-8904
We have developed a stereoselective, glycosyl radical-based method for the synthesis of C-alkyl glycosides via a photomediated defluorinative gem-difluoroallylation reaction. We demonstrate for the first time that glycosyl radicals, generated from gl
Publikováno v:
Organicbiomolecular chemistry. 20(27)
We have developed an improved cyanide-free strategy for the synthesis of glycosyl carboxylic acids, employing stereoselective