Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Xiang-Dong Cheng"'
Autor:
Xiaoqing Guan, Yichao Wang, Wenkai Yu, Yong Wei, Yang Lu, Enyu Dai, Xiaowu Dong, Bing Zhao, Can Hu, Li Yuan, Xin Luan, Kai Miao, Bonan Chen, Xiang‐Dong Cheng, Weidong Zhang, Jiang‐Jiang Qin
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Gastric cancer (GC) presents a formidable global health challenge, and conventional therapies face efficacy limitations. Ubiquitin‐specific protease 7 (USP7) plays pivotal roles in GC development, immune response, and chemo‐resistance, m
Externí odkaz:
https://doaj.org/article/309f94baa7be42939e0ccca5ef7af44d
Autor:
Shengli Li, Li Yuan, Zhi-Yuan Xu, Jing-Li Xu, Gui-Ping Chen, Xiaoqing Guan, Guang-Zhao Pan, Can Hu, Jinyun Dong, Yi-An Du, Li-Tao Yang, Mao-Wei Ni, Rui-Bin Jiang, Xiu Zhu, Hang Lv, Han-Dong Xu, Sheng-Jie Zhang, Jiang-Jiang Qin, Xiang-Dong Cheng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The molecular subtypes of adenocarcinoma of the esophagogastric junction (AEG) remain to be identified. Here, the authors perform proteogenomic characterisation of AEG tumours with paired normal adjacent tissues and suggest three proteomic subtypes a
Externí odkaz:
https://doaj.org/article/8462f76bacab412a96aed2b142c0a420
Autor:
Jinyun Dong, Jing Yang, Wenkai Yu, Haobin Li, Maohua Cai, Jing-Li Xu, Han-Dong Xu, Yun-Fu Shi, Xiaoqing Guan, Xiang‑Dong Cheng, Jiang‑Jiang Qin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2004-2016 (2022)
Gastric cancer remains a significant health burden worldwide. In continuation of our previous study and development of effective small molecules against gastric cancer, a series of benzochalcone analogues involving heterocyclic molecules were synthes
Externí odkaz:
https://doaj.org/article/59f779a14cb74fd68b924c8ac81f8a4e
Autor:
Xiaoqing Guan, Jing Yang, Weiyi Wang, Bing Zhao, Shiyu Hu, Dehua Yu, Li Yuan, Yunfu Shi, Jingli Xu, Jinyun Dong, Jinxin Wang, Xiang-Dong Cheng, Jiang-Jiang Qin
Publikováno v:
Pharmacological Research, Vol 189, Iss , Pp 106703- (2023)
Gastric cancer remains one of the most common deadly diseases and lacks effective targeted therapies. In the present study, we confirmed that the signal transducer and activator of transcription 3 (STAT3) is highly expressed and associated with a poo
Externí odkaz:
https://doaj.org/article/adc2fcc512a74785968012322cbc1977
Autor:
Simin Qi, Xiaoqing Guan, Jia Zhang, Dehua Yu, Xuefei Yu, Qinglin Li, Wenjuan Yin, Xiang-Dong Cheng, Weidong Zhang, Jiang-Jiang Qin
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-18 (2022)
Abstract Background Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted therapies have been develo
Externí odkaz:
https://doaj.org/article/724af697d9fd407d8d9e9c49e0e972b4
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-23 (2021)
Abstract Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely used strategy for treating malignant tumors. However, most intracellular proteins have been proven to be undruggable due to a lack of active sites, leadi
Externí odkaz:
https://doaj.org/article/e9cc8938741d4e12bad704c531da07eb
Autor:
Jing-Li Xu, Li Yuan, Can Hu, Chun-Yan Weng, Han-Dong Xu, Yun-Fu Shi, Ling Huang, Jie-Er Ying, Zhi-Yuan Xu, Jiang-Jiang Qin, Xiang-Dong Cheng
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Trametes robiniophila Murr (TRM) is a traditional Chinese medicine which has been used in clinics for enhancing immunity and improving the efficacy of chemotherapy. However, the mechanisms of action of TRM are unknown. In the previous study, we found
Externí odkaz:
https://doaj.org/article/bf26cca8252d483d968a5be3ec185ca8
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-22 (2020)
Abstract Gastric cancer is a deadly disease and remains the third leading cause of cancer-related death worldwide. The 5-year overall survival rate of patients with early-stage localized gastric cancer is more than 60%, whereas that of patients with
Externí odkaz:
https://doaj.org/article/5b829ff28feb46c1809013705f82be8f
Autor:
Zhi-yuan Xu, Can Hu, Shangqi Chen, Yi-an Du, Ling Huang, Peng-fei Yu, Li-jing Wang, Xiang-dong Cheng
Publikováno v:
BMC Surgery, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background The optimal lymphadenectomy for gastric cancer (GC) with pyloric invasion is controversial because the pattern of lymph node metastasis is different from that of distal GC. The rate of lymph node metastasis into the posterior area
Externí odkaz:
https://doaj.org/article/6098dff8d9a943c5a8645bbf2e3d3c2c
Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate of metastasis and low rate of survival. Despite the advances in understanding this devastating disease, PC still accounts for 3% of all cancers and causes almost
Externí odkaz:
https://doaj.org/article/5579925aac764679b5838dd089464379