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Akademický článek

Cell death in cancer chemotherapy using taxanes

Autor: Ana P. Xu, Lucy B. Xu, Elizabeth R. Smith, Joshua S. Fleishman, Zhe-Sheng Chen, Xiang-Xi Xu

Publikováno v: Frontiers in Pharmacology, Vol 14 (2024)

Cancer cells evolve to be refractory to the intrinsic programmed cell death mechanisms, which ensure cellular tissue homeostasis in physiological conditions. Chemotherapy using cytotoxic drugs seeks to eliminate cancer cells but spare non-cancerous h

Externí odkaz: https://doaj.org/article/cbb7841037eb48aa87decfe110f56a6a

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Akademický článek

Functions and therapeutic potentials of exosomes in osteosarcoma

Autor: Jiaji Yue, Zhe-Sheng Chen, Xiang-Xi Xu, Shenglong Li

Publikováno v: Acta Materia Medica, Vol 1, Iss 4, Pp 552-562 (2022)

Osteosarcoma, a primary malignant tumor of the skeleton, has a morbidity of 2.5 per 1 million people. The epiphysis of extremities is typically affected. Osteosarcoma has a high likelihood of early metastasis, rapid progression, and poor prognosis. T

Externí odkaz: https://doaj.org/article/9e4b1f7a2fbc498dbe4d05c47052fd58

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Akademický článek

Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovarian cancer cells

Autor: Celina Amaya, Shihua Luo, Julio Baigorri, Rogelio Baucells, Elizabeth R. Smith, Xiang-Xi Xu

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)

Abstract Background Paclitaxel (Taxol) is a microtubule-stabilizing drug used to treat several solid tumors, including ovarian, breast, non-small cell lung, and pancreatic cancers. The current treatment of ovarian cancer is chemotherapy using paclita

Externí odkaz: https://doaj.org/article/b202680307cc476ab5deb55ef8f18a59

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Akademický článek

Rationale for combination of paclitaxel and CDK4/6 inhibitor in ovarian cancer therapy — non-mitotic mechanisms of paclitaxel

Autor: Elizabeth R. Smith, Marilyn Huang, Matthew P. Schlumbrecht, Sophia H.L. George, Xiang-Xi Xu

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Taxanes and CDK4/6 inhibitors (CDK4/6i) are two families of successful anti-mitotic drugs used in the treatment of solid tumors. Paclitaxel, representing taxane compounds, has been used either alone or in combination with other agents (commonly carbo

Externí odkaz: https://doaj.org/article/8368702b2245426eb661270bc34a9171

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Akademický článek

Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers

Autor: Callinice D Capo-chichi, Kathy Q Cai, Xiang-Xi Xu

Publikováno v: Biomarker Research, Vol 6, Iss 1, Pp 1-12 (2018)

Abstract Background In most women with ovarian cancer, the diagnosis occurs after dissemination of tumor cells beyond ovaries. Several molecular perturbations occur ahead of tumor initiation including loss of lamin A/C. Our hypothesis was that the lo

Externí odkaz: https://doaj.org/article/c8363ce9a6174b14b090a91424f6ba24

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Akademický článek

Cell death in cancer chemotherapy using taxanes.

Autor: Xu, Ana P., Xu, Lucy B., Smith, Elizabeth R., Fleishman, Joshua S., Zhe-Sheng Chen, Xiang-Xi Xu

Publikováno v: Frontiers in Pharmacology; 2024, p01-08, 8p

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Supplementary Table 1 from Src Inhibition with Saracatinib Reverses Fulvestrant Resistance in ER-Positive Ovarian Cancer Models In Vitro and In Vivo

Autor: Joyce M. Slingerland, Gordon B. Mills, Yiling Lu, Roel G.W. Verhaak, Ji-Yeon Yang, Tan A. Ince, Xiang-Xi Xu, Diana Azzam, Brian Rabinovich, Isildinha M. Reis, Ellis R. Levin, Ali Pedram, Thiago da Silva, Candace A. Gilbert, Wendy Ullmer, Jun Sun, Pedro Hevia-Paez, Fiona Simpkins

PDF file, 46K, List of genes which have one or more ERE in the promoter upstream 10kb region in 111 genes that overlapped in the High ERα and High p416Src groups.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7e32693b853855f4eb0925ec381ca3
https://doi.org/10.1158/1078-0432.22446114

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Data from Src Inhibition with Saracatinib Reverses Fulvestrant Resistance in ER-Positive Ovarian Cancer Models In Vitro and In Vivo

Purpose: More effective, less toxic treatments for recurrent ovarian cancer are needed. Although more than 60% of ovarian cancers express the estrogen receptor (ER), ER-targeted drugs have been disappointing due to drug resistance. In other estrogen-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c473c1c95e7a06f5c9f6eff942571d
https://doi.org/10.1158/1078-0432.c.6520653

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Akademický článek

Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol

Autor: Wensi Tao, Robert Moore, Yue Meng, Elizabeth R. Smith, Xiang-Xi Xu

Publikováno v: Journal of Lipid Research, Vol 57, Iss 5, Pp 809-817 (2016)

High serum cholesterol (hypercholesterolemia) strongly associates with cardiovascular diseases as the atherogenic LDLs promote atheroma development in arteries (atherosclerosis). LDL clearance from the circulation by LDL receptor (LDLR)-mediated endo

Externí odkaz: https://doaj.org/article/4fc78c7e79af4914a10d37680a524b06

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Akademický článek

Defective Nuclear Lamina in Aneuploidy and Carcinogenesis

Autor: Elizabeth R. Smith, Callinice D. Capo-chichi, Xiang-Xi Xu

Publikováno v: Frontiers in Oncology, Vol 8 (2018)

Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer. In high-grade serous ovarian cancer, the only common gene aberrati

Externí odkaz: https://doaj.org/article/6e7734f552f44d128b8e90126a58dc3a

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