Výsledky vyhledávání - "Xiang‐Hong He"

Construction of cyclopenta[b]dihydronaphthofurans via TsOH-catalyzed consecutive biscyclization of dithioallylic alcohols and 1-styrylnaphthols

Autor: He-Ping Li, Xiao-Ling Wu, Gu Zhan, Xue-Ju Fu, Jian-Hua Chen, Xiang-Hong He, Bo Han

Publikováno v: Chemical Communications. 59:2275-2278

The efficient and catalytic biscyclization of dithioallylic alcohols with 1-styrylnaphthols under mild conditions was achieved, thus affording pharmaceutically important cyclopenta[b]dihydronaphthofurans.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2fbda365d3d0f722be85352fae64a60
https://doi.org/10.1039/d2cc06324g

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A Sc(OTf)3-catalyzed one-pot two-step approach for spiro-oxindole dihydropyridine derivatives initiated by N-olefination of MBH carbonates

Autor: Zhen-Hui Yan, Run Lu, Cheng Peng, Jie Tang, Huaying Fang, Gu Zhan, Xiang-Hong He, Wei Huang

Publikováno v: Organic Chemistry Frontiers. 10:2294-2300

An efficient one-pot, two-step, three-component reaction of isatin-derived MBH carbonates, sulfilimines, and epoxides was achieved, thus affording pharmaceutically important spiro-oxindole dihydropyridines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcb05ade4a660d0418fba3370a3fbffb
https://doi.org/10.1039/d3qo00060e

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Organocatalytic asymmetric synthesis of multifunctionalized α-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells

Autor: Xiang-Hong He, Xue-Ju Fu, Gu Zhan, Nan Zhang, Xiang Li, Hong-Ping Zhu, Cheng Peng, Gu He, Bo Han

Publikováno v: Organic Chemistry Frontiers. 9:1048-1055

An asymmetric organocatalytic cascade reaction has been reported for the rapid assembly of multifunctionalized α-carboline-spirooxindole hybrids, which suppressed proliferation in colorectal cancer cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8682dcb90bdd4b05fdcff6ac17ff469
https://doi.org/10.1039/d1qo01785c

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A straightforward access to trifluoromethylated natural products through late-stage functionalization

Autor: He-Ping Li, Xiang-Hong He, Cheng Peng, Jun-Long Li, Bo Han

Publikováno v: Natural product reports.

This review summarizes the applications of late-stage strategies in the direct trifluoromethylation of natural products in the past ten years, with particular emphasis on the reaction model of each method.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c431acd37ea48440aabf682b682179
https://pubmed.ncbi.nlm.nih.gov/36205211

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Organo/Silver Dual Catalytic (3 + 2)/Conia-Ene Type Cyclization: Asymmetric Synthesis of Indane-Fused Spirocyclopenteneoxindoles

Autor: Dong-Ai Li, Xiang-Hong He, Xue Tang, Yuling Wu, Hongli Zhao, Gu He, Cheng Peng, Bo Han, Gu Zhan

Publikováno v: Organic letters. 24(33)

Developing efficient strategies to synthesize spirocyclopenteneoxindoles is an attractive target due to their potential biological activity. This work described the thiourea/silver dual catalytic (3 + 2)/Conia-ene type reaction of 2-(2-oxoindolin-3-y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cd9154b3eaf883c8f8e8ffa8249578
https://pubmed.ncbi.nlm.nih.gov/35976152

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Asymmetric organocatalysis: an enabling technology for medicinal chemistry

Autor: Jun-Long Li, Cheng Peng, Xiang-Hong He, Bo Han, Yanqing Liu, Gu He

Publikováno v: Chemical Society Reviews. 50:1522-1586

The efficacy and synthetic versatility of asymmetric organocatalysis have contributed enormously to the field of organic synthesis since the early 2000s. As asymmetric organocatalytic methods mature, they have extended beyond the academia and undergo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a330ef53f166292731e5dfef880cff1c
https://doi.org/10.1039/d0cs00196a

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Design, Synthesis, and Biological Evaluation of Tetrahydro‐α‐carbolines as Akt1 Inhibitors That Inhibit Colorectal Cancer Cell Proliferation

Autor: Guo Li, Xiang‐Hong He, He‐Ping Li, Qian Zhao, Dong‐Ai Li, Hong‐Ping Zhu, Yue‐Hua Zhang, Gu Zhan, Wei Huang

Publikováno v: ChemMedChem. 17

A series of densely functionalized THαCs were designed and synthesized as Akt1 inhibitors. Organocatalytic [3+3] annulation between indolin-2-imines 1 and nitroallylic acetates 2 provided rapid access to this pharmacologically interesting framework.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ed6f110a276a106cfa38b3218c1907
https://doi.org/10.1002/cmdc.202200104

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