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Akademický článek

TRiC/CCT chaperonin is required for the folding and inhibitory effect of WDTC1 on adipogenesis

Autor: Wen-Shuai Tang, Xiang Cen, Shan-Shan Yao, Shu-Ting Yin, Li Weng, Tong-Jin Zhao, Xu Wang

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Obesity has become a global pandemic. WDTC1 is a WD40-containing protein that functions as an anti-obesity factor. WDTC1 inhibits adipogenesis by working as an adaptor of the CUL4-DDB1 E3 ligase complex. It remains unclear about how WDTC1 is regulate

Externí odkaz: https://doaj.org/article/160fe1e239bd458ca33579cc9f6baf4a

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Akademický článek

Production of 9,21-dihydroxy-20-methyl-pregna-4-en-3-one from phytosterols in Mycobacterium neoaurum by modifying multiple genes and improving the intracellular environment

Autor: Chen-Yang Yuan, Zhi-Guo Ma, Jing-Xian Zhang, Xiang-Cen Liu, Gui-Lin Du, Jun-Song Sun, Ji-Ping Shi, Bao-Guo Zhang

Publikováno v: Microbial Cell Factories, Vol 20, Iss 1, Pp 1-12 (2021)

Abstract Background Steroid drugs are essential for disease prevention and clinical treatment. However, due to intricated steroid structure, traditional chemical methods are rarely implemented into the whole synthetic process for generating steroid i

Externí odkaz: https://doaj.org/article/318de7fbcaec47c083177e8566ca3bd4

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