Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Xiandi. Gong"'
Publikováno v:
The Journal of Biological Chemistry
Carnocyclin A (CclA) is a potent antimicrobial peptide from Carnobacterium maltaromaticum UAL307 that displays a broad spectrum of activity against numerous Gram-positive organisms. An amide bond links the N and C termini of this bacteriocin, imparti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af7229f795155b41197d9b440e67bc0
https://doi.org/10.1074/jbc.m109.036459
https://doi.org/10.1074/jbc.m109.036459
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788:1797-1803
Bacterial resistance to conventional antibiotics is a major challenge in controlling infectious diseases and has necessitated the development of novel approaches in antimicrobial therapy. One such approach is the use of antimicrobial peptides, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3439916cdce4a5c871a47c7e16fd1f
https://doi.org/10.1016/j.bbamem.2009.05.008
https://doi.org/10.1016/j.bbamem.2009.05.008
Publikováno v:
Protein Science
The coronavirus responsible for the severe acute respiratory syndrome (SARS-CoV) contains a small envelope protein, E, with putative involvement in host cell apoptosis and virus morphogenesis. It has been suggested that E protein can form a membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf61f28b4a2b42faada2bd7c46e8318f
https://doi.org/10.1110/ps.062730007
https://doi.org/10.1110/ps.062730007
Publikováno v:
Journal of Biological Chemistry. 279:55283-55289
The cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel contains 12 transmembrane (TM) regions that are presumed to form the channel pore. However, little is known about the relative functional contribution of different TM region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71c9abf4b6c2159bb1e0ef67e42f0fb
https://doi.org/10.1074/jbc.m411935200
https://doi.org/10.1074/jbc.m411935200
Autor:
Canhui Li, Paul Linsdell, Christine E. Bear, Yoshiro Sohma, Bakhrom K. Berdiev, Toby S. Scott-Ward, Xiandi Gong, Ilana Kogan, Hongyu Li, Michael A. Gray, Jeng-Haur Chen, Zhiwei Cai, Tzyh Chang Hwang, Mohabir Ramjeesingh, David N. Sheppard, Jyoti Gupta, Dale J. Benos, Iskander I. Ismailov, Martin J. Hug
Publikováno v:
Journal of Cystic Fibrosis. 3:101-108
Using the patch-clamp (PC) and planar lipid bilayer (PLB) techniques the molecular behaviour of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel can be visualised in real-time. The PC technique is a highly powerful and ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3f53b55868682a5651c220e24e24e1
Autor:
Paul Linsdell, Xiandi Gong
Publikováno v:
Archives of Biochemistry and Biophysics. 426:78-82
Multi-ion pore behaviour has been identified in many Cl − channel types but its biophysical significance is uncertain. Here, we show that mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl − channel that disrupt anion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606c8a1bc133c5ade7a58ca2f961376e
https://doi.org/10.1016/j.abb.2004.03.033
https://doi.org/10.1016/j.abb.2004.03.033
Autor:
Paul Linsdell, Xiandi Gong
Publikováno v:
The Journal of General Physiology
Chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel is blocked by a broad range of anions that bind tightly within the pore. Here we show that the divalent anion Pt(NO2)42− acts as an impermeant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ee61d6780257a25adad8040e760f88
https://doi.org/10.1085/jgp.200308889
https://doi.org/10.1085/jgp.200308889
Publikováno v:
Neurosignals. 12:31-38
Traditional Chinese medicine (TCM) has a long history in stroke therapy and its therapeutic efficacy has been confirmed by clinical studies. The molecular basis of the neuroprotective effects is unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8224e0f01b2008a781ee01d064f0861a
https://doi.org/10.1159/000068913
https://doi.org/10.1159/000068913
Publikováno v:
Biology of Reproduction. 67:1888-1896
Previous studies have shown that two indazole compounds, lonidamine [1-(2,4-dichlorobenzyl)-indazole-3-carboxylic acid] and its analogue AF2785 [(1-(2,4-dichlorobenzyl)-indazol-3acrylic acid], suppress fertility in male rats. We also found that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f791f5b06570af7cdae3c93ea4cc194f
https://doi.org/10.1095/biolreprod.102.007450
https://doi.org/10.1095/biolreprod.102.007450
Publikováno v:
British Journal of Pharmacology. 137:928-936
1. The cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel is blocked by a broad range of organic anionic compounds. Here we investigate the effects of the indazole compound lonidamine on CFTR channels expressed in mammalian cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f087495e573fd3f3363e9ede19cb71
https://doi.org/10.1038/sj.bjp.0704932
https://doi.org/10.1038/sj.bjp.0704932