Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Xianchi Dong"'
Autor:
Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C. Kraft, Jing Li, Viet Q. Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P. Daniel Poulson, Garrett E. Casper, Mary L. Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C. Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M. Chow, Max R. Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K. Finch, David Lowe, Asim K. Bera, Gustavo Matute-Bello, Timothy P. Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R. Cochran, Lance J. Stewart, Melody G. Campbell, Pam M. Van Ry, Timothy Springer, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between homologous αvβ6 and αvβ8 and other RGD integri
Externí odkaz:
https://doaj.org/article/e3c311aafe5446188603fdc35eee2511
Autor:
Mengwen Huang, Xingchao Pan, Xinling Wang, Qingfei Ren, Bei Tong, Xianchi Dong, Gaoxiang Ge, Lu Lu, Shibo Jiang, Jianfeng Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-5 (2023)
Externí odkaz:
https://doaj.org/article/4f27054946114bd682b01b138f1c1366
Autor:
Yuxin Chen, Lin Chen, Shengxia Yin, Yue Tao, Liguo Zhu, Xin Tong, Minxin Mao, Ming Li, Yawen Wan, Jun Ni, Xiaoyun Ji, Xianchi Dong, Jie Li, Rui Huang, Ya Shen, Han Shen, Changjun Bao, Chao Wu
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1524-1536 (2022)
The waning humoral immunity and emerging contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants resulted in the necessity of the booster vaccination of coronavirus disease 2019 (COVID-19). The inactivated vaccine, CoronaVac,
Externí odkaz:
https://doaj.org/article/abb863651da64bb6b65af6dc42888a5b
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Studies in the postfusion structures of the conserved gamete fusogen HAP2 show a trimeric state typical of viral class II fusion proteins. Here, the authors present the crystal structure of a prefusion state of Cyanidioschyzon merolae HAP2 and low re
Externí odkaz:
https://doaj.org/article/65a053c7a96e43a5984cb17b9bc4270f
Autor:
Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer
Publikováno v:
eLife, Vol 10 (2021)
HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of mal
Externí odkaz:
https://doaj.org/article/dd90b1a1d2494b23848064d636afc1d3
Autor:
Fang Tian, Bei Tong, Liang Sun, Shengchao Shi, Bin Zheng, Zibin Wang, Xianchi Dong, Peng Zheng
Publikováno v:
eLife, Vol 10 (2021)
SARS-CoV-2 has been spreading around the world for the past year. Recently, several variants such as B.1.1.7 (alpha), B.1.351 (beta), and P.1 (gamma), which share a key mutation N501Y on the receptor-binding domain (RBD), appear to be more infectious
Externí odkaz:
https://doaj.org/article/6d6d325ec0514285a12b3deb6ab193f0
Autor:
Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Foot-and-mouth disease virus binds αvβ6 integrin, via a conserved RGD motif in the flexible, exposed GH loop of capsid protein VP1, for cell entry. Here Kotechaet al.visualize this interaction with the VP1 GH loop extending away from the viral surf
Externí odkaz:
https://doaj.org/article/7cc85a0a325f47d7981c002ee69ab865
Autor:
Juan Feng, Xianchi Dong, Jennifer Pinello, Jun Zhang, Chafen Lu, Roxana E Iacob, John R Engen, William J Snell, Timothy A Springer
Publikováno v:
eLife, Vol 7 (2018)
HAP2 is a class II gamete fusogen in many eukaryotic kingdoms. A crystal structure of Chlamydomonas HAP2 shows a trimeric fusion state. Domains D1, D2.1 and D2.2 line the 3-fold axis; D3 and a stem pack against the outer surface. Surprisingly, hydrog
Externí odkaz:
https://doaj.org/article/fe98dd9d798e455fb016355889f9e3d7
Autor:
Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo
Publikováno v:
The Journal of Immunology. 209:180-191
The pharmacological inhibition of IDO1 is considered an effective therapeutic approach for cancer treatment. However, the inadequate response of existing holo-IDO1 inhibitors and unclear biomarkers available in clinical practice limit the possibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c857d7f50292a5017cab3c94747c350
https://doi.org/10.4049/jimmunol.2100938
https://doi.org/10.4049/jimmunol.2100938
Autor:
Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo
Publikováno v:
The Journal of Immunology.
Liu, W., Y. Zou, K. Li, H. Zhong, L. Yu, S. Ge, Y. Lai, X. Dong, Q. Xu, and W. Guo. 2022. Apo-form selective inhibition of IDO for tumor immunotherapy. J. Immunol. 209: 180–191. Supplemental Table I did not originally contain the Protein Data Bank
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1313efacc1dc40d5c6f4b4ba07264359
https://doi.org/10.4049/jimmunol.2300257
https://doi.org/10.4049/jimmunol.2300257