Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Xian-le BU"'
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/307cba34a1124afe9336a1402ac188da
Autor:
Dong-Yu Fan, Jie-Ming Jian, Shan Huang, Wei-Wei Li, Ying-Ying Shen, Zhen Wang, Gui-Hua Zeng, Xu Yi, Wang-Sheng Jin, Yu-Hui Liu, Fan Zeng, Xian-Le Bu, Li-Yong Chen, Qing-Xiang Mao, Zhi-Qiang Xu, Jin-Tai Yu, Jun Wang, Yan-Jiang Wang
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Cerebrospinal fluid (CSF) biomarkers are essential for the accurate diagnosis of Alzheimer’s disease (AD), yet their measurement levels vary widely across centers and regions, leaving no uniform cutoff values to date. Diagnostic cutoff val
Externí odkaz:
https://doaj.org/article/6628d6ec43f244b99cd4dbcfa193d93e
Autor:
Yuan Cheng, Jun-Rong Ren, Jie-Ming Jian, Chen-Yang He, Man-Yu Xu, Gui-Hua Zeng, Cheng-Rong Tan, Ying-Ying Shen, Wang-Sheng Jin, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Yuan Zhang, Xian-Le Bu, Yan-Jiang Wang
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract Angiostatin, an endogenous angiogenesis inhibitor generated by the proteolytic cleavage of plasminogen, was recently reported to contribute to the development of Alzheimer’s disease (AD). However, whether there are pathological changes in
Externí odkaz:
https://doaj.org/article/df32bf0bfbcd4218aa9d32685cc19ab7
Autor:
Si-Han Chen, Ding-Yuan Tian, Ying-Ying Shen, Yuan Cheng, Dong-Yu Fan, Hao-Lun Sun, Chen-Yang He, Pu-Yang Sun, Xian-Le Bu, Fan Zeng, Juan Liu, Juan Deng, Zhi-Qiang Xu, Yang Chen, Yan-Jiang Wang
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes in the development of AD remain unclear. In this study, we sought to investiga
Externí odkaz:
https://doaj.org/article/020f408f79fa46908782cba0b3ef9b3e
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Externí odkaz:
https://doaj.org/article/3a8bf687c9694a75922e5e0207af5be4
Autor:
Dong-Yu Fan, Hao-Lun Sun, Pu-Yang Sun, Jie-Ming Jian, Wei-Wei Li, Ying-Ying Shen, Fan Zeng, Yan-Jiang Wang, Xian-Le Bu
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Recent studies show that fibrinogen plays a role in the pathogenesis of Alzheimer’s disease (AD), which may be crucial to neurovascular damage and cognitive impairment. However, there are few clinical studies on the relationship between fibrinogen
Externí odkaz:
https://doaj.org/article/505abce784444aa2a87be533fa5a61ef
Autor:
Lin-Lin Shen, Wei-Wei Li, Ya-Li Xu, Shi-Hao Gao, Man-Yu Xu, Xian-Le Bu, Yu-Hui Liu, Jun Wang, Jie Zhu, Fan Zeng, Xiu-Qing Yao, Chang-Yue Gao, Zhi-Qiang Xu, Xin-Fu Zhou, Yan-Jiang Wang
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Neurofibrillary tangles of hyperphosphorylated tau protein (p-tau) are a key pathological feature of Alzheimer's disease (AD). Tau phosphorylation is suggested to be secondary to amyloid-beta (Aβ) accumulation. However, the mechanism by which Aβ in
Externí odkaz:
https://doaj.org/article/60b967f77cd043368f6417580e846a41
Autor:
Yan-jiang WANG, Xian-le BU, Yang XIANG, Yu-hui LIU, Shu-sheng JIAO, Qing-hua WANG, Fan ZENG, Wang-sheng JIN, Jun WANG, Ling LI, Yang CHEN, Tao ZHANG, Jie ZHU, Juan DENG, Xiu-qing YAO, Chang-yue GAO, Li-li ZHANG, Meng ZHANG, Zhi-qiang XU, Hua-dong ZHOU
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 18, Iss 1, Pp 25-29 (2018)
Alzheimer's disease (AD) becomes a major disease affecting the elderly with high prevalence. However, no disease-modifying therapies are currently available. AD has long been regarded as a disease of brain itself, but recent studies found that system
Externí odkaz:
https://doaj.org/article/e9652512a78a4a2b8e4ee06e607cb003
Autor:
Xin Wang, Fan Zeng, Wang-Sheng Jin, Chi Zhu, Qing-Hua Wang, Xian-Le Bu, Hong-Bo Luo, Hai-Qiang Zou, Jie Pu, Zhong-He Zhou, Xiao-Ping Cui, Qing-Song Wang, Xiang-Qun Shi, Wei Han, Qiang Wu, Hui-Sheng Chen, Hang Lin, Li-Li Zhang, Meng Zhang, Yan Lian, Zhi-Qiang Xu, Hua-Dong Zhou, Tao Zhang, Yan-Jiang Wang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
Abstract Parkinson’s disease (PD) and Parkinsonism are common neurodegenerative disorders with continuously increasing prevalence, causing high global burdens. However, data concerning the comorbidity burden of patients with PD or Parkinsonism in C
Externí odkaz:
https://doaj.org/article/9e39d4c3280f415fb0fb5e4ebbe40ea2
Publikováno v:
Journal of Alzheimer's Disease. 90:1485-1492
Background: Abnormal intracellular expression and aggregation of α-synuclein (α-syn) is the histopathological hallmark of several neurodegenerative diseases especially Parkinson’s disease. However, safe and efficient approaches to clear α-syn re