Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Xian-hui He"'
Autor:
Fu-li Shi, Li-sha Yuan, Tak-sui Wong, Qing Li, Ya-ping Li, Rong Xu, Yi-ping You, Tao Yuan, Hong-rui zhang, Zi-jian Shi, Qing-bing Zha, Bo Hu, Xian-hui He, Dong-yun Ouyang
Publikováno v:
Pharmacological Research, Vol 189, Iss , Pp 106697- (2023)
Necroptosis has been implicated in various inflammatory diseases including tumor-necrosis factor-α (TNF-α)-induced systemic inflammatory response syndrome (SIRS). Dimethyl fumarate (DMF), a first-line drug for treating relapsing-remitting multiple
Externí odkaz:
https://doaj.org/article/ce3aec9a4834464ab895dd0a7a4df808
Autor:
Fan Yang, Xun-jia Ye, Ming-ye Chen, Hong-chun Li, Yao-feng Wang, Mei-yan Zhong, Chun-su Zhong, Bo Zeng, Li-hui Xu, Xian-hui He, Dong-yun Ouyang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Taraxasterol (TAS) is an active ingredient of Dandelion (Taraxacum mongolicum Hand. -Mazz.), a medicinal plant that has long been used in China for treatment of inflammatory disorders. But the underlying mechanism for its therapeutic effects on infla
Externí odkaz:
https://doaj.org/article/6ab6ec2e465a4cd7ab2f4f11a0f988df
Autor:
Chen-Guang Li, Qiong-Zhen Zeng, Ming-Ye Chen, Li-Hui Xu, Cheng-Cheng Zhang, Feng-Yi Mai, Chen-Ying Zeng, Xian-Hui He, Dong-Yun Ouyang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Evodiamine is a major ingredient of the plant Evodia rutaecarpa, which has long been used for treating infection-related diseases including diarrhea, beriberi and oral ulcer, but the underlying mechanism is unclear. Here we aimed to explore whether e
Externí odkaz:
https://doaj.org/article/211252453e6d4d17be32dcb97ce2cdfe
Autor:
Qiong-zhen Zeng, Fan Yang, Chen-guang Li, Li-hui Xu, Xian-hui He, Feng-yi Mai, Chen-ying Zeng, Cheng-cheng Zhang, Qing-bing Zha, Dong-yun Ouyang
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome. However, it remains largely unknown whether p
Externí odkaz:
https://doaj.org/article/8425970e898e49b59618fa83a794b514
Autor:
Wen-Jing Bai, Chen-Guang Li, Cheng-Cheng Zhang, Li-Hui Xu, Qiong-Zhen Zeng, Bo Hu, Zhou Hong, Xian-Hui He, Dong-Yun Ouyang
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
CPT-11 is a first-line chemotherapeutic agent for the treatment of colorectal cancer in clinic. Previous studies including ours have demonstrated that CPT-11 is, however, toxic to the intestinal epithelium and resident peritoneal macrophages. By inte
Externí odkaz:
https://doaj.org/article/b4e0a4d939db44cda3d44f8c9291a954
Autor:
Yi Liu, Yan-Yun Jing, Chen-Ying Zeng, Chen-Guang Li, Li-Hui Xu, Liang Yan, Wen-Jing Bai, Qing-Bing Zha, Dong-Yun Ouyang, Xian-Hui He
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2018)
The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of NLRP3 inflammasome has been linked to a variety of inflammatory diseases. Thus targeting the NLRP3 inflammas
Externí odkaz:
https://doaj.org/article/b6c8d637d5934511862813747960e184
Autor:
Chen-Guang Li, Liang Yan, Feng-Yi Mai, Zi-Jian Shi, Li-Hui Xu, Yan-Yun Jing, Qing-Bing Zha, Dong-Yun Ouyang, Xian-Hui He
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The flavonoid baicalin has been reported to possess potent anti-inflammatory activities by suppressing inflammatory signaling pathways. However, whether baicalin can suppress the activation of NOD-like receptor (NLR) family, pyrin containing domain 3
Externí odkaz:
https://doaj.org/article/60744548f2904122851476da0201aa05
Autor:
Qing-Bing Zha, Hong-Xia Wei, Chen-Guang Li, Yi-Dan Liang, Li-Hui Xu, Wen-Jing Bai, Hao Pan, Xian-Hui He, Dong-Yun Ouyang
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
ATP is released by bacteria and host cells during bacterial infection as well as sterile tissue injury, acting as an inducer of inflammasome activation. Previous studies have shown that ATP treatment leads to AMP-activated protein kinase (AMPK) activ
Externí odkaz:
https://doaj.org/article/ac33fa8d8033494190b190b6d63d20a2
Autor:
Yi-Dan Liang, Wen-Jing Bai, Chen-Guang Li, Li-Hui Xu, Hong-Xia Wei, Hao Pan, Xian-Hui He, Dong-Yun Ouyang
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Piperine is a phytochemical present in black pepper (Piper nigrum Linn) and other related herbs, possessing a wide array of pharmacological activities including anti-inflammatory effects. Previously, we demonstrated that piperine has therapeutic effe
Externí odkaz:
https://doaj.org/article/97e0b9000290457ca636d0367d12ac2f
Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity.
Autor:
Qing-Bing Zha, Xiao-Yu Zhang, Qiu-Ru Lin, Li-Hui Xu, Gao-Xiang Zhao, Hao Pan, Dan Zhou, Dong-Yun Ouyang, Ze-Huan Liu, Xian-Hui He
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124355 (2015)
Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce autophagy. However, the correlation between such activities is largely unknown. In this study, we a
Externí odkaz:
https://doaj.org/article/5b5a4fe2eade4246a116773957acd870