Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Xian-Sen Huo"'
Autor:
Xian‐Sen Huo, Ji Tang‐Yang, Wen‐Bin Zeng, Xie‐Er Jian, Xuan‐Xuan Ma, Peng Yue‐Yang, You Wen‐Wei, Pei‐Liang Zhao
Publikováno v:
Drug Development Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0d915e089f88c224e6dbe4c98798bb0
https://doi.org/10.1002/ddr.22066
https://doi.org/10.1002/ddr.22066
Publikováno v:
Bioorganicmedicinal chemistry letters. 66
Based on our previous work, a series of novel triazolylthioacetones incorporating pyridine, pyrazine, and 3,4,5-trimethoxybenzyl fragment were synthesized, and evaluated for antiproliferative activities and interactions with tubulin. Some analogues e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a886679eedf62017b0701462ed13af
https://pubmed.ncbi.nlm.nih.gov/35398303
https://pubmed.ncbi.nlm.nih.gov/35398303
Autor:
Xian-Sen Huo, Yu-Feng Ma, Zhi-Ru Chen, Li-Li Yuan, Xiao-Lan Zheng, Xiong-Li Li, Feng-Ting Liang, Wen-Wei You, Peiliang Zhao
A novel series of 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide derivatives has been achieved successfully via an efficient one-pot three-component Biginelli-like heterocyclization reaction between different benzaldehydes, 1H-1,2,4-triazole-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::858a0da04e772787f7c7965eb1d65928
https://doi.org/10.21203/rs.3.rs-182311/v1
https://doi.org/10.21203/rs.3.rs-182311/v1
Autor:
Pei-Liang Zhao, Ren-Xin He, Yu-Feng Ma, Wen-Wei You, Qiu Li, Xian-Sen Huo, Lin Chen, Xie-Er Jian, Yu Wang
Publikováno v:
Bioorganicmedicinal chemistry letters. 31
Based on our previous work, a novel class of 8-cyclopentyl-7,8-dihydropteridin-6(5H)-one derivatives were synthesized and evaluated as antiproliferative agents. Structure-activity relationship analysis revealed that the greatest activities were achie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0711b6c1c441042515d8fd83034c52b8
https://pubmed.ncbi.nlm.nih.gov/33197548
https://pubmed.ncbi.nlm.nih.gov/33197548
Autor:
Wen-Wei You, Qiu Li, Jin-Jun Rao, Lin Chen, Xie-Er Jian, Zi-Hua Li, Pei-Liang Zhao, Xian-Sen Huo, Zhi-Ru Chen
Publikováno v:
Bioorganic chemistry. 102
A new series of derivatives characterized by the presence of the 3,4,5-trimethoxylbenzamide substituted benzofurans were synthesized and evaluated for antiproliferative activity against four cancer cell lines and one normal human cell line. Among the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c97046cb94c0b2f09b3e8327bd4d37e
https://pubmed.ncbi.nlm.nih.gov/32683180
https://pubmed.ncbi.nlm.nih.gov/32683180
Autor:
Lin Chen, Xian-Sen Huo, Fang Yang, Xie-Er Jian, Jie Ou-Yang, Dong-Xin Lv, Jin-Jun Rao, Pei-Liang Zhao, You Wenwei
Publikováno v:
European Journal of Medicinal Chemistry. 220:113449
By removing 5-methyl and 6-acetyl groups in our previously reported compound 3, we designed a series of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential tubulin polymerization inhibitors. Among them, compound 5e displayed lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de758aa906e9cedb33cc7e206b3b2269
https://doi.org/10.1016/j.ejmech.2021.113449
https://doi.org/10.1016/j.ejmech.2021.113449
Autor:
Yan-Hong Li, Yu-Feng Ma, Meng-Jin Hu, Pei-Liang Zhao, Wei-Feng Ma, Shengquan Zheng, Peng-Cheng Diao, Xian-Sen Huo, Wen-Wei You, Fang Yang, Peng Chen
Publikováno v:
European Journal of Medicinal Chemistry. 208:112847
Based on our prior work, we reported the design, synthesis, and biological evaluation of fifty-two new triazolothiadiazine-based analogues of CA-4 and their preliminary structure-activity relationship. Among synthesized compounds, Iab was found to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a82a0d0bdaf6cc37dffd9daa165f7b
https://doi.org/10.1016/j.ejmech.2020.112847
https://doi.org/10.1016/j.ejmech.2020.112847
Publikováno v:
European Journal of Medicinal Chemistry. 204:112625
On the basis of our previous work, twenty-nine novel [1,2,4]triazolo[4,3-a]pyridines possessing 3,4,5-trimethoxylphenyl groups were designed, synthesized, and evaluated as tubulin polymerization inhibitors. The bioassay results revealed that some of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088951f72a9ce990fe3ecbee5e50dcbe
https://doi.org/10.1016/j.ejmech.2020.112625
https://doi.org/10.1016/j.ejmech.2020.112625