Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Xian-Ming Chen"'
Autor:
Zinat Sharmin, Kehua Jin, Ai-Yu Gong, Silu Deng, Chansorena Pok, Marion L. Graham, Shuhong Wang, Nicholas W. Mathy, Annemarie Shibata, Xian-Ming Chen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Intestinal epithelial cells possess the requisite molecular machinery to initiate cell-intrinsic defensive responses against intracellular pathogens, including intracellular parasites. Interferons(IFNs) have been identified as cornerstones of epithel
Externí odkaz:
https://doaj.org/article/08639b7b6277458cbbca556868d87ac1
Autor:
Silu Deng, Wei He, Ai-Yu Gong, Min Li, Yang Wang, Zijie Xia, Xin-Tiang Zhang, Andrew S. Huang Pacheco, Ankur Naqib, Mark Jenkins, Patrick C. Swanson, Kristen M. Drescher, Juliane K. Strauss-Soukup, Michael Belshan, Xian-Ming Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Cryptosporidium parvum virus 1 is a virus harbored by the pathogenic protozoan Cryptosporidium parvum, and whose role in parasite biology and host interactions remains unclear. Here, Deng et al. demonstrate the impact this virus has on host response
Externí odkaz:
https://doaj.org/article/9b1e06c8f71d4bc8939f5c194e11c17d
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cryptosporidium is a zoonotic apicomplexan parasite that infects the gastrointestinal epithelium and other mucosal surfaces in humans. It is an important opportunistic pathogen in AIDS patients and a leading cause of infectious diarrhea and diarrheal
Externí odkaz:
https://doaj.org/article/56c99b480aa444628956eddee091dc94
Autor:
Nicholas W. Mathy, Olivia Burleigh, Andrew Kochvar, Erin R. Whiteford, Matthew Behrens, Patrick Marta, Cong Tian, Ai-Yu Gong, Kristen M. Drescher, Peter S. Steyger, Xian-Ming Chen, Annemarie Shibata
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Microglia are resident immunocompetent and phagocytic cells in the CNS. Pro-inflammatory microglia, stimulated by microbial signals such as bacterial lipopolysaccharide (LPS), viral RNAs, or inflammatory cytokines, are neurotoxic
Externí odkaz:
https://doaj.org/article/c05633b3953e4b29bcf9fdd58896b15f
Autor:
Nicholas W. Mathy, Silu Deng, Ai-Yu Gong, Min Li, Yang Wang, Olivia Burleigh, Andrew Kochvar, Erin R. Whiteford, Annemarie Shibata, Xian-Ming Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The cells of the intestinal epithelium establish the frontline for host defense against pathogens in the gastrointestinal tract and play a vital role in the initiation of the immune response. Increasing evidence supports the role of long non-coding R
Externí odkaz:
https://doaj.org/article/1682e4a1ea924a9bb2e96bcd602b762c
Publikováno v:
Pathogens, Vol 12, Iss 2, p 319 (2023)
Protozoan parasites, such as Plasmodium, Leishmania, Toxoplasma, Cryptosporidium, and Trypanosoma, are causative agents of health-threatening diseases in both humans and animals, leading to significant health risks and socioeconomic losses globally.
Externí odkaz:
https://doaj.org/article/e9767f98e9184d67925819587690c52f
Autor:
Ai-Yu Gong, Yang Wang, Min Li, Xin-Tian Zhang, Silu Deng, Jessie M. Chen, Eugene Lu, Nicholas W. Mathy, Gislaine A. Martins, Juliane K. Strauss-Soukup, Xian-Ming Chen
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can
Externí odkaz:
https://doaj.org/article/0801779eeecf4115bddb57f5ae461f83
Autor:
Zijie Xia, Jihao Xu, Eugene Lu, Wei He, Silu Deng, Ai-Yu Gong, Juliane Strass-Soukup, Gislaine A. Martins, Guoqing Lu, Xian-Ming Chen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Increasing evidence supports that N6-methyladenosine (m6A) mRNA modification may play an important role in regulating immune responses. Intestinal epithelial cells orchestrate gastrointestinal mucosal innate defense to microbial infection, but underl
Externí odkaz:
https://doaj.org/article/49b7356a2d00468b9b3cd7da134ec019
Autor:
Guoku Hu, Ke Liao, Fang Niu, Lu Yang, Blake W. Dallon, Shannon Callen, Changhai Tian, Jiang Shu, Juan Cui, Zhiqiang Sun, Yuri L. Lyubchenko, Minhan Ka, Xian-Ming Chen, Shilpa Buch
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 450-463 (2018)
Impairment of microglial functions, such as phagocytosis and/or dysregulation of immune responses, has been implicated as an underlying factor involved in the pathogenesis of various neurodegenerative disorders. Our previous studies have demonstrated
Externí odkaz:
https://doaj.org/article/51e3e2dd9fb94ff78a1ad28e4e55b662
Autor:
Juan Li, Kehua Jin, Min Li, Nicholas W Mathy, Ai-Yu Gong, Silu Deng, Gislaine A Martins, Mingfei Sun, Juliane K Strauss-Soukup, Xian-Ming Chen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009241 (2021)
The gastrointestinal epithelium guides the immune system to differentiate between commensal and pathogenic microbiota, which relies on intimate links with the type I IFN signal pathway. Epithelial cells along the epithelium provide the front line of
Externí odkaz:
https://doaj.org/article/8e135fa0067f427dbdaf6e761d8fed03