Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Xian-Li Jiang"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Genetic sensors can be created by mix and matching DNA-binding modules with ligand-binding modules. Here the authors use a computational model to overcome module incompatibilities and restore function by rescuing key interactions.
Externí odkaz:
https://doaj.org/article/cec9375bf6eb42b9bab94705b00a26b9
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The connection between genetic variation and drug response has long been explored to facilitate the optimization and personalization of cancer therapy. Crucial to the identification of drug response related genetic features is the ability to
Externí odkaz:
https://doaj.org/article/4709e04e25cf472b984a02fd84ae8513
Autor:
Hector E. Sanchez-Ibarra, Luisa M. Reyes-Cortes, Xian-Li Jiang, Claudia M. Luna-Aguirre, Dionicio Aguirre-Trevino, Ivan A. Morales-Alvarado, Rafael B. Leon-Cachon, Fernando Lavalle-Gonzalez, Faruck Morcos, Hugo A. Barrera-Saldaña
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The treatment of Type 2 Diabetes Mellitus (T2DM) consists primarily of oral antidiabetic drugs (OADs) that stimulate insulin secretion, such as sulfonylureas (SUs) and reduce hepatic glucose production (e.g., biguanides), among others. The marked int
Externí odkaz:
https://doaj.org/article/e8dc387a52c344119133d7c99c2eeebd
Autor:
Dustin P. Patterson, Xian-Li Jiang, Joseph S. Glavy, Clement T Y Chan, Benjamin R Jordan, Rey P Dimas, Catherine Martini, Faruck Morcos
Publikováno v:
Nucleic Acids Research
The development of synthetic biological systems requires modular biomolecular components to flexibly alter response pathways. In previous studies, we have established a module-swapping design principle to engineer allosteric response and DNA recognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbc39bd31d6a0096d51316a71101c03
http://europepmc.org/articles/PMC6895282
http://europepmc.org/articles/PMC6895282
Autor:
Kunping Liu, Lan Yang, Feng Li, Jianming Hu, Kai Liu, Xian Li Jiang, Liyan Zhang, Weihua Liang, Xueli Wang, Ji Hong Liu, Chunxiao Li
Publikováno v:
Diagnostic Pathology, Vol 14, Iss 1, Pp 1-9 (2019)
Diagnostic Pathology
Diagnostic Pathology
Background Tumour-associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumours. Epithelial-mesenchymal transition (EMT) is a mechanism for tumour invasion and metastasis. In this study, we aimed to determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e59d994f45b117053755ed21638dbaa
http://link.springer.com/article/10.1186/s13000-019-0834-0
http://link.springer.com/article/10.1186/s13000-019-0834-0
Publikováno v:
Nucleic Acids Research
Engineering allosteric transcriptional repressors containing an environmental sensing module (ESM) and a DNA recognition module (DRM) has the potential to unlock a combinatorial set of rationally designed biological responses. We demonstrated that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160121a48564a9fb1fba0def7dc6cc71
http://europepmc.org/articles/PMC6547410
http://europepmc.org/articles/PMC6547410
Publikováno v:
Entropy
Entropy, Vol 23, Iss 170, p 170 (2021)
Volume 23
Issue 2
Entropy, Vol 23, Iss 170, p 170 (2021)
Volume 23
Issue 2
Two-component systems (TCS) are signaling machinery that consist of a histidine kinases (HK) and response regulator (RR). When an environmental change is detected, the HK phosphorylates its cognate response regulator (RR). While cognate interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec84a0f589f2225d72fc670dcebcb82c
http://europepmc.org/articles/PMC7911359
http://europepmc.org/articles/PMC7911359
Autor:
Hector E. Sanchez-Ibarra, Hugo A. Barrera-Saldaña, Yenho Chen, Faruck Morcos, Adriana Carolina Cavazos-González, Xian-Li Jiang, Elena Yareli Gallegos-Gonzalez
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235490 (2020)
PLoS ONE, Vol 15, Iss 7, p e0235490 (2020)
Mutations in KRAS, NRAS, and BRAF (RAS/BRAF) genes are the main predictive biomarkers for the response to anti-EGFR monoclonal antibodies (MAbs) targeted therapy in metastatic colorectal cancer (mCRC). This retrospective study aimed to report the mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16addc47466dff202dffaca020aa745
https://pubmed.ncbi.nlm.nih.gov/32628708
https://pubmed.ncbi.nlm.nih.gov/32628708
Autor:
Jiang Fen Li, Yu Fang Xie, Wei Hua Liang, Hai Jun Zhang, Xue Li Wang, Ji Hong Liu, Kai Liu, Xian Li Jiang, Chen Hao Jiang, Xin Yuan, An Zhi Zhang, Li Juan Pang, Xiao Bin Cui, Lan Yang, Chun Xia Liu, Wen Yi Gu, Feng Li, Jian Ming Hu
Publikováno v:
SSRN Electronic Journal.
Background Tumor-associated macrophages (TAMs) are an important immune cell component of the tumor microenvironment. This study aimed to explore the molecular mechanism of TAMs phenotype transformation and the role in the development of esophageal sq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33b22985684ad76c9ed52b0b4e93784
https://doi.org/10.2139/ssrn.3684449
https://doi.org/10.2139/ssrn.3684449
Autor:
Jin Fang Jiang, Xi Hua Shen, Hong Zou, Lan Yang, Wei Hua Liang, Jin Zhao, Xue Li Wang, Feng Li, Shu Gang Li, Chun Xia Liu, Yun Zhao Chen, Jian Ming Hu, Ji Hong Liu, Li Juan Pang, Xiao Bin Cui, Xian Li Jiang, Kai Liu, Xiang Lin Yuan
Publikováno v:
Oncotarget
M2 macrophages was domesticated by tumor microenvironment to produce some angiogenic molecules and protease, facilitating angiogenesis and matrix breakdown, promoting tumor invasive and metastasis. However, The function of M2 macrophages to progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ec578fb59bf054ca0b6672ca246660
http://europepmc.org/articles/PMC5400603
http://europepmc.org/articles/PMC5400603