Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Xian-Cheng Jiang"'
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Intracellular hemoglobin polymerization has been supposed to be the major determinant for the elevated rigidity/stiffness of sickle erythrocytes from sickle cell anemia (SCA) patients. However, the contribution of the cell envelop
Externí odkaz:
https://doaj.org/article/cb2565ff4bee431cbfd313b8da6db19c
Autor:
Qing Zhang, Deqiang Yao, Bing Rao, Liyan Jian, Yang Chen, Kexin Hu, Ying Xia, Shaobai Li, Yafeng Shen, An Qin, Jie Zhao, Lu Zhou, Ming Lei, Xian-Cheng Jiang, Yu Cao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
During phosphatidylcholine (PC) remodeling re-acylation is catalyzed by lysophosphatidylcholine acyltransferases (LPCAT). Here, the authors present crystal and cryo-EM structures of chicken LPCAT3 in the apo-, acyl donor-bound and acyl receptor-bound
Externí odkaz:
https://doaj.org/article/6de1b72018e541e28fd5d13bfcea2813
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/95e96430948f4858adadf4f8d88e0677
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103449- (2021)
Summary: Glucosylceramide (GluCer) was accumulated in sphingomyelin synthase 1 (SMS1) but not SMS2 deficient mouse tissues. In current study, we studied GluCer accumulation-mediated metabolic consequences. Livers from liver-specific Sms1/global Sms2
Externí odkaz:
https://doaj.org/article/c1534ea8bb3b4764a344f509814da050
Autor:
Xian-Cheng Jiang
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 5, Pp 764-771 (2018)
Phospholipid transfer protein (PLTP) is one of the major modulators of lipoprotein metabolism and atherosclerosis development in humans; however, we still do not quite understand the mechanisms. In mouse models, PLTP overexpression induces atheroscle
Externí odkaz:
https://doaj.org/article/24433809bd06473899cced2d2ebdad9f
Autor:
Wen Guo, Yingyun Gong, Yong Gu, Zhenzhen Fu, Hongqi Fan, Beibei Gao, Xiaohui Zhu, Jinxiang Fu, Yang Zhao, Min Sun, Xing Liu, Xian-Cheng Jiang, Tao Yang, Hongwen Zhou
Publikováno v:
Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-8 (2018)
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9), which plays a crucial role in lipoprotein metabolism, has been also regarded as an important marker for atherosclerosis. Available evidence indicated that 2-h postchallenge pl
Externí odkaz:
https://doaj.org/article/0e8f300f3f9c487f9b420bc0eefd5067
Autor:
Jing Xue, Yang Yu, Xiangjian Zhang, Cong Zhang, Yanan Zhao, Boyan Liu, Lan Zhang, Lina Wang, Rong Chen, Xuan Gao, Peng Jiao, Guohua Song, Xian‐Cheng Jiang, Shucun Qin
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 22 (2019)
Background Inflammation is recognized as an important contributor of ischemia/reperfusion (I/R) damage after ischemic stroke. Sphingomyelin synthase 2 (SMS2), the key enzyme for the biosynthesis of sphingomyelin, can function as a critical mediator o
Externí odkaz:
https://doaj.org/article/6aa2a640b22342bf9e81703a803c5060
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2019)
Mammalian cell membrane phosphatidylcholines (PCs), the major phospholipids, exhibit diversity which is controlled by Lands' cycle or PC remodeling pathway. Lysophosphatidylcholine acyltransferase (LPCAT) is one of the major players in the pathway an
Externí odkaz:
https://doaj.org/article/899692d8e27342018b1f79f337775aed
Autor:
David G. Thomas, Amanda C. Doran, Panagiotis Fotakis, Marit Westerterp, Per Antonson, Hui Jiang, Xian-Cheng Jiang, Jan-Åke Gustafsson, Ira Tabas, Alan R. Tall
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3774-3785.e4 (2018)
Summary: The activation of liver X receptor (LXR) promotes cholesterol efflux and repression of inflammatory genes with anti-atherogenic consequences. The mechanisms underlying the repressive activity of LXR are controversial and have been attributed
Externí odkaz:
https://doaj.org/article/75d63901b5094ee292734e51cc911855
Autor:
Yang Yu, Xia Lei, Hui Jiang, Zhiqiang Li, John W. M. Creemers, Ming Zhang, Shucun Qin, Weijun Jin, Xian‐Cheng Jiang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 9 (2018)
BackgroundPhospholipid transfer protein (PLTP) is one of the major modulators of lipoprotein metabolism and atherosclerosis development; however, little is known about the regulation of PLTP. The effect of hepatic prodomain of furin (profurin) expres
Externí odkaz:
https://doaj.org/article/bec16fea4432418ca533a9e2fc4361c3