Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Xian-Chao Cheng"'
Autor:
Wei Liu, Xian-Chao Cheng, Shu-Qing Wang, Run-Ling Wang, Ying Ma, Wen-Bo Liu, Xiao-Bo Li, Su-Xia Sun
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 6, Pp 12661-12674 (2013)
Over expressing in PTPN1 (encoding Protein tyrosine phosphatase 1B, PTP1B), a protein tyrosine phosphatase (PTP) that plays an overall positive role in insulin signaling, is linked to the pathogenesis of diabetes and obesity. The relationship between
Externí odkaz:
https://doaj.org/article/fbb67cfec6b94c08a4b849ba6cafcb79
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 5, Pp o1130-o1130 (2011)
The title compound, C16H20O4, was obtained unintentionally as the byproduct of an attempted synthesis of methyl 3-(cyclopropylmethoxy)-4-hydroxybenzoate. In the crystal, the molecules are linked by intermolecular C—H...O interactions.
Externí odkaz:
https://doaj.org/article/1fcf36bd6fa3433e884b3f6acbcca0d2
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 1, Pp e12-e12 (2011)
The chemical diagram and the title of the paper by Hou et al. [Acta Cryst. (2010), E66, o2004] are corrected.
Externí odkaz:
https://doaj.org/article/f2e7325083364c8abff48011f1c4b7e1
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 11, Pp o2961-o2961 (2010)
In the title compound, C17H14BrClN4O2, the pyrazole ring is almost coplanar with the benzene ring [dihedral angle = 0.5 (2)°], whereas the pyrazole ring is close to perpendicular to the 3-chloropyridine ring [dihedral angle = 73.7 (2)°]. An intramo
Externí odkaz:
https://doaj.org/article/8a1af559b2284af89c22366e6d8ddabb
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 8, Pp o2004-o2004 (2010)
In the title compound, C12H14O4, the dihedral angle between the benzene ring and the cyclopropyl ring is 60.3 (4)°. In the crystal structure, molecules are linked by intermolecular O—H...O hydrogen bonds into chains running parallel to [101].
Externí odkaz:
https://doaj.org/article/bf4b020f162e451e9c26c69bf8a0949c
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 8, Pp o2027-o2027 (2010)
In the title molecule, C11H12N2O4, the dihedral angle between the benzene ring and imidazolidine ring is 7.1 (5)°. In the crystal structure, the hydroxy groups are involved in the formation of intermolecular O—H...O hydrogen bonds, which link the
Externí odkaz:
https://doaj.org/article/8e18a01db61141c8b8f34e1b8c28c25d
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 6, Pp o1308-o1308 (2010)
In the title compound, C10H10N2O3, the dihedral angle between the benzene and imidazolidine rings is 6.0 (4)°, consistent with an essentially planar molecule. In the crystal, intermolecular N—H...O hydrogen bonding between centrosymmetrically rela
Externí odkaz:
https://doaj.org/article/354bdb366753445eae6d95feadaa4a6f
Autor:
Su-Xia Sun, Hao Zhang, Xian-Chao Cheng, Zhihui Zheng, Ting-Ting Ding, Run-Ling Wang, Li-Song Zhang, Yang-Chun Ma, Xin-Hua Lu, Ya-Ya Liu
Publikováno v:
Biochemical and Biophysical Research Communications. 579:40-46
Protein tyrosine phosphatase 1B (PTP1B) is a member of the phosphotyrosine phosphatase family and plays an important role in the signal transduction of diabetes. Inhibition of PTP1B activity can increase insulin sensitivity and reduce blood sugar lev
Publikováno v:
Letters in Drug Design & Discovery. 17:772-786
Background: Phosphoinositide-3 kinases (PI3Ks) are key signaling molecules that affect a diverse array of biological processes in cells, including proliferation, differentiation, survival, and metabolism. The abnormal activity of PI3K signals is clos
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 39:1853-1864
PPARα and PPARγ play important roles in regulating glucose and lipid metabolism. In recent years, the development of dual PPAR agonists has become a hot topic in the field of anti-diabetic medicina...