Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Xian Ping Lu"'
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have garnered attention as a viable target for therapeutic intervention. A variety of HDAC inhibitors (HDACis) have been deve
Externí odkaz:
https://doaj.org/article/d9a261daa6cb42d2b649425d48e72d24
Autor:
De-Si Pan, Wei Wang, Nan-Song Liu, Qian-Jiao Yang, Kun Zhang, Jing-Zhong Zhu, Song Shan, Zhi-Bin Li, Zhi-Qiang Ning, Laiqiang Huang, Xian-Ping Lu
Publikováno v:
PPAR Research, Vol 2017 (2017)
Type 2 diabetes mellitus is often treated with insulin-sensitizing drugs called thiazolidinediones (TZD), which improve insulin resistance and glycemic control. Despite their effectiveness in treating diabetes, these drugs provide little protection f
Externí odkaz:
https://doaj.org/article/365f8ce9205349ffaf44581615a003db
Publikováno v:
Chinese Journal of Clinical Oncology. 4:307-312
OBJECTIVE To explore the method of preparation of 99mTc labeled Anti-VEGF McAb 5-FU loaded polylactic acid nanoparticles (99mTc-5-FU-Ab-NPs), and investigate the biological distribution of the nanoparticles in human gas -tric carcinoma xenografts. ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a818f34e1ffbe6554790b9e2e2574b21
https://doi.org/10.1007/s11805-007-0307-1
https://doi.org/10.1007/s11805-007-0307-1
Autor:
Chen Zhong Liao, Ben Ko, Zhong Wen Wu, Zhi Bin Li, Zhi Qiang Ning, Xian Ping Lu, Shan Song, Jing Cheng, Tuo Deng
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:1192-1196
Retinoid X receptor (RXR) forms heterodimers with peroxisome proliferator-activated receptors (PPARs, with subtypes of alpha, delta and gamma), and the heterodimers can be activated by either an RXR or a PPAR subtype-specific ligand. Based on the che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0389968615e7209fad1e318ce3d3ad
https://doi.org/10.1248/bpb.28.1192
https://doi.org/10.1248/bpb.28.1192
Publikováno v:
Journal of Chemical Information and Computer Sciences. 44:230-238
Eigenvalue analysis (EVA) was conducted on a series of Potent agonists of peroxisome proliferator-activated receptor gamma (PPARgamma). Predictive EVA quantitative structure-activity relationship (QSAR) models were established using the SYBYL package
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e566f592a06d84be3ef28a498fae9b6
https://doi.org/10.1021/ci034109c
https://doi.org/10.1021/ci034109c
Autor:
Magnus Pfahl, Xian-Ping Lu, Bruce Carter, Andrea Fanjul, Shiping Tang, Michaela Pfahl, Karen Nared Hood, Eric Fabbrizio, Deepa Rungta, Javier Piedrafita, Nathalie Picard
Publikováno v:
Nature Medicine. 3:686-690
Lung cancer causes more than 140,000 deaths annually in the United States alone, and the prognosis for non-small cell lung cancer (NSCLC) is particularly poor. Therapies using small molecules that preferentially kill lung tumor cells by inducing cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec987ed0cbe8a1806611753c4ea78c9
https://doi.org/10.1038/nm0697-686
https://doi.org/10.1038/nm0697-686
Publikováno v:
Molecular Endocrinology. 8:1774-1788
The COUP transcription factors (COUP-TF and ARP-1) are the most highly conserved members of the nuclear receptor superfamily throughout evolution. Previous studies indicated that COUP orphan receptors may be involved in early neurogenesis in Drosophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1bb829f63e800e5eafdcc0d803d804
https://doi.org/10.1210/mend.8.12.7708064
https://doi.org/10.1210/mend.8.12.7708064
Autor:
Seong-Jin Kim, G. Salbert, Andrea Fanjul, Xian Ping Lu, F J Piedrafita, P. Tran, Magnus Pfahl
Publikováno v:
Molecular Endocrinology. 7:1347-1356
Overexpression of the multifunctional growth factor transforming growth factor-beta 1 (TGF beta 1) has been connected to numerous diseases in human. TGF beta 1 expression is largely governed by three AP-1 binding sites located in two different promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a26d2d15ef10dd2156fe6b0ac33b53
https://doi.org/10.1210/mend.7.10.8264664
https://doi.org/10.1210/mend.7.10.8264664
Publikováno v:
Molecular and Cellular Biology. 13:6509-6519
Retinoid X receptors (RXR) have been identified as common subunits in the regulation of multiple hormonal signaling pathways. Using circular permutation and phasing analysis of specific response elements, we present evidence that RXR-retinoic acid re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65495a033a8058daabf44c5529280545
https://doi.org/10.1128/mcb.13.10.6509
https://doi.org/10.1128/mcb.13.10.6509
Publikováno v:
European neurology. 63(1)
Background/Aims: Between 50 and 70% of stroke survivors suffer from severe disabilities such as paralysis and aphasia. Poor stroke outcome is a reflection of our incomplete understanding of the underlying mechanisms, and hence the capacity to impleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff03668cd7bd21b9e7d0de035b0b06c
https://pubmed.ncbi.nlm.nih.gov/20029217
https://pubmed.ncbi.nlm.nih.gov/20029217